IndraLab

Statements

SOS1 binds LAT and GRB2. 12 / 12
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"These data suggest an interesting hypothesis whereby multivalent, cooperative interactions between LAT, Grb2, and Sos1 promote LAT oligomerization, whereas recruitment of PLC-γ1–GADS-SLP-76 complexes block Grb2-LAT associations, and therefore limit the overall size of LAT oligomers."
24222714
sparser
"Multivalent interactions of pLAT with either Grb2 and Sos1, or Gads and SLP-76 are sufficient to promote this effect."
30951647
sparser
"The cooperative interaction of LAT, Sos1 and Grb2, as well as LAT-Gads-SLP-76-ADAP allow for the assembly of macromolecular LAT signaling complexes, which are essential for T-cell signaling ( xref , xref , xref – xref )."
34456914
sparser
"Consistent with this idea, clustering of LAT at the T cell-APC interface requires multivalent interactions between LAT, Grb2, and Sos1 ( xref )."
30951647
sparser
"Moreover, by binding multiple Grb2 molecules to LAT, the Grb2-Sos1-LAT interaction mediates oligomerization of LAT."
34456914
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"The exclusion of CD45 was recapitulated in a simpler system in which clusters were formed by pLAT, Grb2, and Sos1 ( xref )."
27056844
sparser
"The phosphatase CD45 is excluded from Lat:Grb2:Sos1 clusters, while other effector proteins are enriched there."
31913664
sparser
"Biophysical studies assessing the interactions between LAT, Grb2, and Sos1 have shown that Sos1 has two distinct Grb2-binding sites in its proline-rich region (PRR), and that Sos1 and Grb2 can form a 1:2 complex ( xref )."
24222714
sparser
"Interestingly, activation of ERK1/2 is delayed relative to protein kinase C, xref suggesting that this alone is not sufficient to activate the MAPK pathway, leading us to speculate that this delay is as a result of assembly of the LAT-Grb2-SOS1 signaling complex."
24265393
sparser
"Furthermore, biophysical ( xref ) and modeling ( xref ) studies showed that multiple, cooperative interactions between LAT, Grb2, and Sos1 regulate the efficiency of higher-order LAT oligomerization."
24222714
sparser
"The existence of multivalent interactions between LAT:Grb2 (1:3) and Sos1:Grb2 (1:2) has led to the hypothesis that Grb2–Sos1–Grb2 complexes may nucleate LAT oligomerization ( xref )."
24222714
sparser
"Based on the multiplicity of Sos1:Grb2 and LAT:Grb2 interactions, it was hypothesized that the Grb2–Sos1–Grb2 complex could nucleate LAT oligomerization."
24222714