IndraLab

Statements

AKT activates phosphorylated MTOR. 8 / 8
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"Although not addressed by the present study, it is likely that Akt, which is activated by ischemia, 49 activates p-mTOR at S2448."
27935582
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"Since Akt promotes oncogenesis by inhibiting apoptosis and promoting proliferation of cancer cells directly as well as indirectly by regulating the activation of NF-kappaB and p-mTOR, we investigated the mechanism by CDDO-Me inhibits Akt."
22177954
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"Moreover, the combined inhibition of both p38 and Akt in CsA treated animals was more effective and more significantly reduced p-Akt (p = 0.0001), p-p38 (p = 0.02) and p-mTOR as compared to CsA (alone)-treatment group (XREF_SUPPLEMENTARY)."
22820192
eidos
"Chronologically , AKT can stimulate p-mTOR that is an upstream protein 38-40 ."
32913473
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"As expected, the MAPK inhibitor U0126 effectively decreased p-ERK1/2 protein expression (0.01 +/-0.01-fold versus 1 +/-0.2-fold vehicle treated, P < 0.001), and the PI3K inhibitor LY294002 decreased p-Akt (0.01 +/-0.01-fold versus 1 +/-0.09-fold vehicle treated), downstream Akt target p-mTOR (0.5 +/-0.2-fold versus 1 +/-0.2-fold vehicle treated), downstream mTOR target p-70S6 kinase (0.02 +/-0.02-fold versus 1 +/-0.1-fold vehicle treated)."
24472707
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"This is in sharp contrast to Hs578T cells where a distinct AKT signal fails to activate p-mTOR S2448 and an activation of pRSK S380 is not promoted in this cell line."
28675785
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"In our study, we found that PI3K-AKT-mTOR pathway proteins in normal rats were expressed at low levels, while there was increased expression of p-AKT, p-mTOR and p-P70S6K in brain tissues of anaesthetized rats treated with PI3K and Akt agonists."
27340771
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"Chronologically, AKT can stimulate p-mTOR that is an upstream protein XREF_BIBR - XREF_BIBR."
32913473