IndraLab

Statements

SHC binds EGF and EGFR. 5 / 5
| 5
sparser
"EGF but Not Thrombin Stimulates EGF Receptor Tyrosine Phosphorylation and Association of Shc with Phosphotyrosine-containing Proteins."
11266444
sparser
"In co-stimulation experiments, carbachol and EGF activated MAPK in a non-additive fashion; moreover, EGF-induced association of Shc with the phosphorylated EGF receptor was inhibited by carbachol."
10816433
sparser
"Pretreatment of serum-starved cells with GSE resulted in 70% to almost complete inhibition of EGF-induced EGFR activation and 50% to complete inhibition of Shc activation, which corroborated with a comparable decrease in EGF-induced Shc binding to EGFR."
12618755
sparser
"However, in aged cells Shc was unable to form stable complexes with EGFR after EGF stimulation."
10795716
sparser
"As expected, in the absence of EGF, Shc is not associated with the EGFR."
25503978