IndraLab

Statements

RAS binds MAP2K1 and RAF1. 6 / 6
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"Within the SGZ of the adult brain, we now report elevations in genes associated with both IL-6Rα and gp130, as well as genes associated with downstream signaling through Ras to activate Raf-1 or MAP2K1."
20833246
sparser
"The binding of PEA-15 was specific to ERK among the components of the ERK MAP kinase pathway, since PEA-15 failed to interact with Ras, Raf1, or MEK1 ."
11702783
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"Consistent with the preferential binding of MEK-1 to RAS:RAF-1, the basal activity of MEK-1 in v-ras-transformed cells was found to be elevated sixfold, whereas MEK-2 was elevated only twofold, suggesting that the RAS signalling pathway favors MEK-1 activation."
7969158
sparser
"Through interaction with Raf-1, RKTG changes the localization of Raf-1 from cytoplasm to the Golgi apparatus, blocks EGF-stimulated Raf-1 membrane translocation, and reduces the interaction of Raf-1 with Ras and MEK1."
17724343
sparser
"Overexpression of dominant-negative forms of Ras , Raf-1 , and MEK1 in transgenic mice results in defective positive but normal negative selection."
12433368
sparser
"Transient transfection of Pa-4 cells with active forms of Ras, Raf-1, or MEK1 resulted in decreases of occludin mRNA levels, which can be reversed by the MEK inhibitor PD98059."
10854690