IndraLab

Statements

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"On the other hand, the recent finding that USP1 contributes to block differentiation in osteosarcoma [XREF_BIBR] raises the possibility that USP1 inhibition could be explored as a strategy for differentiation therapy in this tumor type."
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"Therefore, USP1 silencing in OS cells leads to the decreased stability of IDs proteins and increased osteoblastic differentiation."
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"Conversely, ectopic expression of USP1 in MSCs stabilizes IDs proteins and inhibits osteoblastic differentiation."
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"USP1 promotes the proteasomal degradation of Foxp3 by deubiquitinating and stabilizing TAZ, thereby attenuating Treg differentiation (32)."
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"Finally, USP1 knockdown in osteosarcoma cells causes cell‐cycle arrest and osteogenic differentiation."
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"Besides, USP1 promotes Th17-cell differentiation but attenuates Treg-cell differentiation (45)."
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"Considering the action of the proteins ID, USP1 contributes to prevent differentiation mediated by bHLH and, consequently, keep CSC original characteristics."
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"Overexpression of USP1 in MSCs inhibits osteogenic differentiation and promotes the preservation of MSC features."
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"A fraction of primary human osteosarcomas were found to overexpress both USP1 and ID proteins, and ectopic USP1 expression in mesenchymal stem cells stabilized ID proteins, blocked differentiation, an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ectopic expression of USP1 in mesenchymal stem cells inhibited osteoblastic differentiation, and enhanced cell proliferation through stabilizing ID (inhibitor of DNA binding) proteins [11]."
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"USP1, in turn, promotes Th17 cell differentiation and attenuates Treg cell differentiation, thereby promoting the development of inflammatory diseases [77]."
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"In various types of cancer, USP1 is often overexpressed and mediates the stabilization of inhibitors of DNA binding and cell differentiation (ID proteins family) to regulate tumor proliferation, metastasis and apoptosis [29]."
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"Other USP1 activities include involvement in a feedback loop to limit DDR CHK1 protein kinase activity , and the regulation of cellular differentiation in osteosarcoma cells by deubiquitylating and hence affecting the stability of inhibitors of DNA-binding proteins ."
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"Knockdown of USP1 promotes osteogenic differentiation ( Williams et al., 2013 )."
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"Finally, USP1 inhibits cell differentiation by stabilizing tumor promoting inhibitor of DNA binding (ID) proteins XREF_BIBR, XREF_BIBR."
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"In addition, USP1 inhibition accelerated osteogenic differentiation and promoting PI3K/Akt signaling in MC3T3-E1 cells."
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"USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation, thereby promoting the development of inflammatory diseases."
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"USP1 inhibition accelerated osteogenic differentiation and increasing PI3K/Akt signaling in MC3T3-E1 cells."
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"Interestingly, USP1 knockdown causes osteoblast differentiation in these cells."
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"Importantly, USP1 knockdown results in decreased mesenchymal cell proliferation, and enhanced differentiation of osteosarcoma cells which overexpress USP1 and ID1, providing a rationale for differentiation therapy of many cancer types including leukemia (e.g. acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML))."
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"Notably, ML323, a specific inhibitor of the USP1/UAF1 deubiquitinase complex, inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo, indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg cells."
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"As expected, inhibition of USP1 may enhance the osteogenic differentiation of MC3T3-E1 in vitro by activating PI3K/Akt signaling pathway, which were consistent with previous studies [54–56]."
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"These data, together with a study showing that misregulated ID expression inhibits osteogenic differentiation (Peng et al., 2004), prompted us to investigate whether USP1 overexpression disrupts hMSC [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The USP1 protein leads to regulated DNA repair through deubiquitination and homologous recombination pathways, and inhibits cell differentiation by stabilizing tumor-promoting inhibitors of DNA-binding proteins."
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"Collectively, our observations suggest that overexpression of USP1 or ID2 is sufficient to block osteoblastic differentiation, promote retention of stem like features, and render cells resistant to di[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP1 overexpression not only was necessary for the proliferation of several osteosarcoma cell lines, it also was sufficient to prevent normal mesenchymal cell differentiation, capturing the cells in a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, USP1 overexpression perturbs normal osteoblast differentiation, which is characterized by p53 independent upregulation of multiple CDKIs (Funato et al., 2001; Kenner et al., 2004; Matsumoto et a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ID2 or USP1 overexpression in mesenchymal stem cells inhibited osteogenic differentiation and promoted retention of mesenchymal stem cell features."
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