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TP53 binds MDM2 and NGFR. 4 / 4
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"This finding explained why NGFR, MDM2 and p53 could form a ternary complex ( xref )."
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"Nevertheless, our studies as shown in this manuscript do confirm that nuclear NGFR can bind to p53 and MDM2, consequently inactivating p53 by directly inhibiting its transcriptional activity and facilitating MDM2-dependent ubiquitination and degradation."
27282385
sparser
"Thus, we tested if p53 binds to NGFR directly or indirectly through MDM2."
27282385
sparser
"Demonstration of the endogenous interaction between NGFR, MDM2 and p53 in SK-N-SH cells shown in xref is central to the paper and this needs to be repeated using reciprocal IPs and cell fractionation."
27282385