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TP53-R172P activates apoptotic process. 2 / 2
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"We used the p53 (R172P) knock-in mouse, which is unable to induce apoptosis but retains intact cell-cycle arrest and cellular senescence pathways, to show that spontaneous tumorigenesis is potently repressed in Terc -/- p53 (R172P) mice."

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"The p53 R172P mutant, which can activate p21 - the major cell cycle regulator transcriptionally activated by p53 - but not apoptosis target genes (Text Box 1) has helped to address this question [XREF_BIBR]."