IndraLab

Statements

Mutated EGFR increases the amount of EGFR. 4 / 4
| 4
reach
"Human EGFR (EGFR; HER-1) is over-expressed in 40%-60% of primary GBM tumours and mostly occurs in the classical subtype (XREF_FIG) [XREF_BIBR], but EGFR mutation which leads to EGFRvIII expression (XREF_FIG) present in 20%-30% of primary GBM [XREF_BIBR]."
33680090
reach
"Therefore, the exact mechanism remains unclear whether EGFR mutation is the major contributor to EGFR overexpression."
22500280
reach
"It is also possible that EGFR is able to override DOK2 mediated inhibition via mechanisms such as increased expression of EGFR driven by amplification of the mutant EGFR allele."
24255704
reach
"One type of EGFR mutation in primary gliomas results in overexpression of an aberrant EGFR messenger RNA (mRNA) that lacks sequences of exons II through VI of the human EGFR gene."
9554440