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CDH1 binds CTNNB1 and LEF1. 2 / 2
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"40,42,47–49 Moreover, it has been shown that the LEF-1-β-catenin complex binds in vitro to the E-cadherin promoter to regulate the transcription of this gene, suggesting that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we observed that increased E-cadherin expression in ovarian carcinoma cells was associated with increased E-cadherin promoter activity, increased adherens junction formation, decreased beta-catenin signaling-dependent LEF-1 activity, and the generation of cohesive spheroids in basement membrane gel culture."
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