IndraLab

Statements

Mutated TP53 increases the amount of TP53. 25 / 25
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"Muller et al XREF_BIBR showed that p53 mutation upregulates expression of endogenous p53, binds to caspase-9 and ultimately inhibits apoptosis and mediates cisplatin resistance."
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"Treatment with poly (I : C) had no impact on WT or p53 mutant mediated expression of the p53 target genes p21 and PUMA (BBC3) (XREF_SUPPLEMENTARY)."
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"Indeed, tumours harbouring p53 mutations, which lead to expression of inactive p53 protein, account for about 50% of all human cancers."
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"The mutation of the P53 gene in tumors will cause the imbalance of the protein level of P53, which will lead to further tumor expansion."
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"Mutant p53 does not induce the expression of wild-type (wt) p53 downstream genes because of the loss of the ability to bind to p53 response elements [XREF_BIBR, XREF_BIBR]."
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"Dominant negative effects of mutant p53 have been shown to suppress wild-type p53 expression and function."
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"While it is known that a mutant p53 protein can interact with its wild-type counterpart to inac- tivate the function of the wild-type protein (domi- nant negative mutation), there is also evidence tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"P53 mutations increase expression of p53 and bind with the p35 fragment of caspase-9, which inhibits caspase-9 activity and eventually leads to CDDP resistance in cancer."
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"Transient expression of mutant p53 protein in TSGH8301 cells may induce an irreversibly stabilization of p53 and increase the steady state of p53 expression."
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"Second, we determined p53 overexpression as a surrogate marker for p53 mutation; however, not all p53 mutations lead to p53 overexpression."
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"These results were expected since overexpression is never observed in cases of wild type TP53, meanwhile not all TP53 mutations lead to p53 overexpression."
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"In fact, p53 protein overexpression could be caused by different TP53 mutation patterns."
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"Mutations of the p53 tumor suppressor gene often result in overexpression of the p53 protein."
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"The overexpression of p53, detected by IHC and qPCR, was mainly caused by TP53 mutations, which correlates with the results obtained by Yemelyanova et al, stating that the immunohistochemical pattern of p53 in tumors is a predictor of TP53 mutations [XREF_BIBR]."
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"XREF_FIG demonstrates that in the total cell lysate of virtually all the lymphoma cell lines with either wild-type (wt) or mutant p53, doxorubicin treatment increased p53 protein levels starting at 3h, and the increases were sustained at 6 and 24 h (the results from DoHH2, JOK-1, and DHL-4 cells are shown; anti-p53 antibody : FL393)."
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"This result indicates that (1) the abnormal p53 expression is usually not caused by mutations of the p53 gene in PPC and (2) PPC is part of a growing number of tumors that share evidence of p53 dysfunction in the absence of mutation."
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"Furthermore, we also extended our studies to search for possible p53 mutants which might cause the abberant expression of wild type p53, but we detected p53 mutants only in 2 of our 14 cases.On the ot[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We thus asked whether mutant p53 would be able to modulate the expression of classical wild-type p53 responsive target genes."
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"Previous studies concentrated on the employment of immunostaining as a screening study to identify tumours containing p53 DNA mutations based on the premise that p53 mutations led to overexpression of p53 protein."
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"As reviewed by Stiewe and Haran [16], cancer-associated mutations alter p53 in three ways: they promote the loss of wild-type (wt) p53 DNA binding, trigger dominant-negative inhibition of wtp53 by the mutant p53 in the monoallelic mutation setting, or induce the gain of new functions by mutant p53 through new protein–protein–DNA interactions."
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"The lead compounds were able to stabilize not only the active conformation of wild-type p53 but also the mutant p53 forms, inducing the transcription of p53 target genes."
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"This study took advantage of previous work demonstrating that mutations of TP53 often result in overexpression of P53."
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"Tubo-ovarian and peritoneal high-grade serous carcinoma (HGSC) is characterized by aberrant p53 expression induced by a TP53 mutation."
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"The p53 mutation in DLD1 may cause the high expression of p53 and contribute to the higher IC50 of resveratrol."
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"Overexpression of p53 can be caused by both increased production of wild-type p53 and by production of mutant p53."
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