IndraLab
Statements
reach
"Loss of linkage between the cell-cell adhesion molecule E-cadherin and the actin cytoskeleton, that is mediated by a three protein link of beta-catenin, alpha-catenin and alpha-actinin, is induced by association of the EGF receptor having the protein tyrosine kinase activity with beta-catenin that leads to tyrosine phosphorylation of beta-catenin and concomitant dissociation of alpha-catenin from it [XREF_BIBR, XREF_BIBR]."
reach
"In untreated cancer cells, fluorescence immunostaining demonstrated beta-catenin in the nucleus and/or cytoplasm; in TZD treated cancer cells, beta-catenin localization shifted to the plasma membrane, in association with increased E-cadherin at this site and reduced tyrosine phosphorylation of beta-catenin."