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BAP1 activates BRCA1. 17 / 20
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"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
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"The association of BAP1, a Ub carboxy-terminal hydrolase, suggests that BRCA1 mediated ubiquitination is tightly regulated, and there is evidence that BAP1 can potentiate BRCA1 tumor suppressor functi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, p53 and BRCA1-related protein 1 (BAP1) induce ferroptosis in tumor cells through multiple signaling pathways, which act as a natural barrier to cancer development (5, 6)."
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"Initially identified in a yeast two-hybrid screen using the RING-finger domain of the breast cancer type 1 susceptibility protein BRCA1 as bait, BAP1 was shown to enhance BRCA1 mediated growth suppression in MCF7 cells [XREF_BIBR]."
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"Conceivably, BAP1 might modulate BRCA1 mediated tumor suppression by hydrolyzing ubiquitin moieties from the BRCA1 and BARD1 heterodimer, its associated proteins, or even its substrates [61]."
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"BRCA1-associated protein-1 (BAP1), a ubiquitin C-terminal hydrolase (UCH), was firstly identified as a DUB to mediate BRCA1 stability [15]."
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"Their studies revealed differential expression of the cancer-related lncRNAs Malat1, Neat1, H19, Meg3, and their associated miRNA-target pairs, regulating various hallmarks of tumorigenesis such as cell cycle and p53 signaling.BRCA1-Associated Protein 1 (BAP1) is known to enhance BRCA1 tumor suppressor potential and its inactivation is associated with various cancers, in particular clear-cell renal cell carcinoma (ccRCC)."
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"BRCA1-associated protein 1 (BAP1) is the translation product of BRCA1 and belongs to the family of deubiquitinating enzymes."
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"It is still not known whether BAP1 functions to modulate BRCA1 ubiquitynating activity and/or to regulate ubiquitin dependent degradation of BRCA1 itself."
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"Surprisingly, BAP1 mediated growth suppression is independent of wild-type BRCA1."
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"Although BAP1 has been hypothesized to function in BRCA1 mediated processes, our results, and others ', support the possibility of BRCA1 independent functions of BAP1."
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"However, IR caused BRCA1 degradation was attenuated by PT33 treatment in BAP1 deficient cells, which may be caused by PT33 inducible proteasome inhibition32 (Fig. 5A)."
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"Interestingly, BRCA1 proteins were decreased in the MM cells with BAP1 deletion, and transduction of the mutants as well as WT BAP1 increased BRCA1 proteins, suggesting that BAP1 may promote DNA repair partly through stabilizing BRCA1."
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"To examine whether BAP1 mediates BRCA1 protein stability through deubiquitination modification, ubiquitination test was performed."
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"It was found that downregulation of BAP1 increased the degradation rate of BRCA1 protein in cells."
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"XREF_BIBR suggested that BAP1 could function for HR repair in the BRCA1 related pathway, and they hypothesized that BAP1 enables BRCA1 to readily accumulate DSB sites."
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"But BAP1 deficiency markedly decreased the BRCA1 foci after IR (Fig. 5B and Fig. S10)."
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