IndraLab

Statements

BAP1 activates BRCA1. 10 / 13
| 10
reach
"Surprisingly, BAP1 mediated growth suppression is independent of wild-type BRCA1."
18757409
reach
"XREF_BIBR suggested that BAP1 could function for HR repair in the BRCA1 related pathway, and they hypothesized that BAP1 enables BRCA1 to readily accumulate DSB sites."
26011428
reach
"Initially identified in a yeast two-hybrid screen using the RING-finger domain of the breast cancer type 1 susceptibility protein BRCA1 as bait, BAP1 was shown to enhance BRCA1 mediated growth suppression in MCF7 cells [XREF_BIBR]."
21484256
reach
"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
32944533
reach
"Interestingly, BRCA1 proteins were decreased in the MM cells with BAP1 deletion, and transduction of the mutants as well as WT BAP1 increased BRCA1 proteins, suggesting that BAP1 may promote DNA repair partly through stabilizing BRCA1."
26011428
reach
"The association of BAP1, a Ub carboxy-terminal hydrolase, suggests that BRCA1 mediated ubiquitination is tightly regulated, and there is evidence that BAP1 can potentiate BRCA1 tumor suppressor functi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12507552
reach
"It is still not known whether BAP1 functions to modulate BRCA1 ubiquitynating activity and/or to regulate ubiquitin dependent degradation of BRCA1 itself."
16337408
reach
"BRCA1-associated protein 1 (BAP1) is the translation product of BRCA1 and belongs to the family of deubiquitinating enzymes."
33209689
reach
"Conceivably, BAP1 might modulate BRCA1 mediated tumor suppression by hydrolyzing ubiquitin moieties from the BRCA1 and BARD1 heterodimer, its associated proteins, or even its substrates [61]."
11790560
reach
"Although BAP1 has been hypothesized to function in BRCA1 mediated processes, our results, and others ', support the possibility of BRCA1 independent functions of BAP1."
18757409