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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Ubiquitinated TP53 increases the amount of TP53. 2 / 2

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"Together, these results indicate that Hoxa2 negatively affects RCHY1 stability and RCHY1 dependent ubiquitination of p53 thereby inducing a stabilization of p53 and an increase in p53 protein level."

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"In unstressed cells, p53 is constitutively polyubiquitinated, which leads to its proteasomal degradation, keeping p53 levels low (Gomez-Lazaro et al., 2004) ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...