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AKT increases the amount of HIF1A. 78 / 87
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"Studies have shown that Akt can augment HIF-1alpha expression by increasing its translation under both normoxic and hypoxic conditions [XREF_BIBR - XREF_BIBR]."
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"On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K and Akt signaling."
17145871
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"The inhibition of Akt signaling attenuates the expression of HIF-1alpha and the synthesis of SDF-1."
21607542
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"Arsham and colleagues showed that constitutively activated Akt was able to increase the level of HIF-1alpha protein in glioblastoma but not hepatoma cells [XREF_BIBR]."
19342157
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"Akt signaling can also enhance the expression of HIF-1alpha to amplify the expression of HIF target genes."
19920186
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"Second, Akt can upregulate HIF-1alpha expression by increasing mTOR mediated protein translation and/or inhibiting GSK3beta facilitated, VHL independent protein degradation [XREF_BIBR, XREF_BIBR]."
25821081
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"In our study, the AKT and mTOR and ERK pathways were up-regulated by PDGF and caused increased levels of HIF-1alpha and VEGF in HSCs."
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"For instance, insulin, insulin -like growth factor (IGF), epidermal growth factor (EGF) and fibroblast growth factor (FGF) can induce expression of HIF-1alpha protein in normoxia via mitogen activated protein kinase (MAPK) and PI3K and Akt pathways."
19843849
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"Akt signaling functions to induce HIF-1alpha expression."
19372575
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"There appear to be yet more wrinkles in this story, as both HIF1alpha and HIF2alpha were shown to bind the SIRT1 gene promoter and induce its expression under hypoxia 88, and AKT activity can induce both HIF1alpha and SIRT1 expression by downregulating miR199a-5p expression 89."
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"Akt dependent signaling also leads to increased expression of HIF-1alpha and VEGF, two molecules that also lead to increased angiogenesis [XREF_BIBR]."
21526896
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"Importantly, HIF-1alpha expression was downregulated by THC by inhibiting Akt and mTOR and p38 MAPK pathways."
29207631
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"Several studies revealed that miR-494 could target PTEN, leading to activate PI3K and Akt pathway which could augment HIF-1alpha expression [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
24364919
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"miR-21, on the other hand, is classified as an oncogene 66 because it exerts an anti-apoptotic function in cancer cells 67 as well as induces angiogenesis by activating Akt and ERK signaling pathways, which increase HIF-1alpha and VEGF expression 68."
32764607
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"PI3K and Akt could upregulate the expression of HIF1alpha and induce the transcription of VEGF gene to increase the expression of VEGF, which in turn induce angiogenesis and increase blood supply of tumors [XREF_BIBR, XREF_BIBR]."
26985248
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"In addition, suppression of Akt activation by wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, decreased HIF-1alpha and VEGF expression."
23819061
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"Inhibition of AKT signaling by MK2206 also reduced the HIF-1alpha and ROCR2 levels, indicating HIF-1alpha is one of the transcription factors involved in the AKT mediated ROCR2 activation (XREF_FIG, second panel)."
28744012
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"Cd can significantly reduce the expression of PI3K, AKT and HIF-1alpha in the three lymph nodes."
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"It is well known that the protein level of HIF-1alpha is up-regulated by hypoxia, and it has also been shown that transcription of the HIF1A gene is promoted by activation of the PI3K-Akt and MAPK pathways XREF_BIBR, XREF_BIBR."
30002387
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"TNFalpha- or hypoxia induced secretion of VEGF and IL-8 and expression of HIF-1alpha were hampered by treatment with the PI3 kinase inhibitor LY294002, suggesting that inhibition of PI3 kinase and Akt activation might inhibit VEGF and IL-8 secretion and HIF-1alpha expression induced by TNFalpha or hypoxia."
19859713
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"XREF_BIBR HIF signalling has been linked to the regulation of myeloid cell survival, XREF_BIBR and HIF-1alpha expression is increased by activation of the PI3K and Akt pathway, XREF_BIBR a signaling cascade known to be dysregulated in AML."
20376086
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"In the present study, PI3K and Akt pathway inhibition by LY294002 significantly reduced the mRNA levels of IL-6, HIF-1alpha, Glut-1, and PDK-1 induced by D-lactate and bTNF-alpha."
33796579
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"Furthermore, we showed that the expression of VEGF and HIF1-alpha was modulated by PI3K and AKT signaling."
32322211
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"Therefore, our results indicate that Akt can augment HIF-1alpha expression by increasing its translation under both normoxic and hypoxic conditions; however, the pathway we are investigating seems to be rapamycin insensitive and mTOR independent."
16849522
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"Pretreatment of ARPE-19 cells with LY294002 suppressed HIF-1alpha protein accumulation and VEGF mRNA expression, suggesting the involvement of PI3K and Akt activation in HIF-1alpha expression and its downstream VEGF gene expression in ARPE-19 cells (data not shown)."
26446654
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"As part of the proliferation cue, Akt induces expression of c-Myc and Hif1a -- two other key oncogenes, which trans-activate genes coding for metabolic enzymes."
33673109
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"Exposure to Abeta increases phosphorylation of mTOR via serine/threonine protein kinase B (Akt), which increases the expression of HIF-1a, the master transcriptional regulator of glycolysis."
33717134
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"This mechanism may be involved in the activation of the PI3K and Akt pathway, which subsequently upregulates the expression of hypoxia inducible factor 1-alpha (HIF-1alpha) and promotes transcription and secretion of VEGF, and eventually leads to promote tumor angiogenesis through VEGF binding to vascular endothelial cell surface receptors."
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"PA-BSA coupling with GPR40 significantly induced Akt activation which is required for mTOR and p70S6K1 mediated HIF-1alpha expression and NF-kappaB phosphorylation facilitating the transcriptional activity of the APP and BACE1 genes."
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"Similarly, in human tumoral cell lines, pharmacological inhibition of the PI3K and Akt pathway was shown to reduce the mRNA expression of Glut-1 as well as the protein levels of HIF-1alpha and PDK-1."
33796579
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"For example, the ERK-PI3K and Akt mediate HIF-1alpha levels by stimulating protein synthesis of the molecular chaperone Hsp90, which in turn is able to stabilize HIF-1alpha in an oxygen independent fashion."
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"In the same setting, AKT inhibition downregulates the expression of HIF-1alpha induced by CASC9 [XREF_BIBR, XREF_BIBR]."
| PMC
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"Specific inhibition of AKT reduced the expression of HIF-1alpha and survivin, whereas specific inhibition or depletion of HIF-1alpha reduced survivin expression but had no effect on the expression of phosphorylated AKT."
24165223
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"Blocking mTOR or PI3K and AKT activity markedly reversed hypoxia induced HIF-1alpha expression and VEGF secretion, strongly supporting the notion that the induction of HIF-1alpha and VEGF is largely regulated by the PI3K/AKT/mTOR pathway."
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"(i) It has been described previously that constitutively activated Akt upregulates HIF-1alpha expression in melanoma in vivo, suggesting a feedback mechanism of Akt activity through HIF-1alpha level that can be abrogated by hyperactivation of Akt."
19934275
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"The AKT and ERK inhibitors, LY294002 and U0126, suppressed HIF-1alpha and VEGF expression and angiogenesis."
21544242
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"CA IX-pY activates Akt which promotes the expression of Hif-1a which, in turn, enhances the expression of CA IX facilitating acidosis and tumor cell invasion [XREF_BIBR]."
23992304
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"Under hypoxia, the AKT pathway significantly increases the expression of hypoxia inducible factor-1alpha (HIF-1alpha), which further affects the phosphorylation of AKT."
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"For example, forced PTEN overexpression reduces HIF1alpha expression, whereas activated PI3K and AKT signaling upregulates HIF1alpha expression [XREF_BIBR, XREF_BIBR]."
25896712
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"Akt and mTORC1 increase HIF1alpha protein levels and knockdown of cavin-3 progressively increased both HIF1alpha levels and the use of fermentative glycolysis (XREF_FIG)."
24069528
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"AKT increased expression of SDF-1, CXCR4, and HIF-1alpha."
25792870
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"However, for the parental lung cancer cells, PI3K and Akt signaling directly regulated HIF-1alpha expression, and this biological process was not associated with HSP70."
27278081
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"Transfection of a plasmid encoding constitutively active AKT slightly increased the expression of HIF-1alpha and VEGF by Salmonella treatment in comparison with the control group."
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"The activation of Akt was reported to augment HIF-1alpha expression by increasing its translation under normoxic and hypoxic conditions XREF_BIBR, and the Akt and mTOR dependent translation of HIF-1alpha was reported to play a critical role in the post-irradiation up-regulation of intratumoral HIF-1 activity XREF_BIBR."
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"For example, the PI3K-Akt pathway contributes to pulmonary fibrosis by inducing expression of HIF-1alpha and VEGF."
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"Akt activation increases HIF-1alpha expression by increasing its translation under both normoxic and hypoxic conditions [XREF_BIBR]."
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"Blocking PI3K and AKT or mTOR activity dramatically diminished hypoxia induced HIF-1alpha expression and VEGF generation in hypoxic T24 cells, suggesting that the VEGF/VEGFR2/PI3K/AKT/mTOR cascade contributes to the induction of HIF-1alpha and VEGF."
28710377
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"Sulforaphane was also found to inhibit hypoxia induced HIF-1alpha expression through activating JNK and ERK signaling pathways, but not AKT pathway."
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"As described earlier, PI3K and Akt pathway is known to upregulate HIF-1alpha and VEGF expression in an mTOR dependent manner XREF_BIBR, XREF_BIBR."
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"Inhibition of Akt by LY294002 inhibited the expression of the downstream molecules HIF1-alpha, survivin and VEGF, but LY294002 treatment increased TRPC3 expression in ES-2 cells, while not in HEY cells, may due to intrinsic features of the two cell lines."
23580589
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"The PI3K-PKB and Akt pathway can not directly regulate the expression or stability of hypoxia inducible factor-1alpha, but it can indirectly regulate expression because it has numerous downstream targets."
25206699
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"It has been reported that the PI-3 kinase and Akt signaling pathway mediates angiogenesis and the expression of VEGF in cells by elevating the levels of HIF-1alpha protein in cells independent of hypo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Meanwhile, Akt can augment HIF-1alpha expression by increasing its translation [XREF_BIBR] and HIF-1alpha expression through activating PI3K and Akt pathway under both normoxia and hypoxia, and had protective effects against hypoxia induced apoptosis in L02 cells [XREF_BIBR]."
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"T3 up-regulate the expression of VEGF and HIF-1alpha by PI3K and AKT signaling pathway As shown in XREF_FIG, the doses of 10 -7 M and 10 -9 M T3 increased mRNA and protein expression of VEGF and HIF-1alpha in OA osteoblasts after 24 hr and 48 hr."
32695299
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"We found that arsenic exposure could activate the PI3K and AKT pathway, further induce the high expression of HIF-1alpha, and then upregulate the levels of miRNA-21 and VEGF, promote the expression of proliferating cell nuclear antigen (PCNA), and ultimately lead to malignant cell proliferation."
32124230
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"However, the PI3K and Akt pathway, which can upregulate HIF-1alpha expression, was activated in these lesions and may be responsible for the non hypoxic upregulation of HIF-1alpha expression (Tanaka et al, 2006)."
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"A previous study found that activating the AKT and ERK signaling pathways could enhance HIF-1a and VEGF expression in some malignant tumors [XREF_BIBR]."
27456341
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"PI3K and Akt Signaling Pathway and the NF-kappaB Activity Mediate D-Lactate-Induced Expression of HIF-1alpha, Glut-1, and PDK-1 in bFLS."
33796579
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"Inhibition of the PI3K and Akt pathway by treatment with LY294002 (PI3K inhibitor) decreased the expression of HIF-1alpha and VEGF-A (XREF_SUPPLEMENTARY)."
26919097
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"Both processes are dependent on activities of transcription factors, such as HIF-1 and NF-kappaB, as well as the activation of the PI3K and Akt signaling pathway, which contribute to an increased expression of IL-6, HIF-1alpha, Glut-1, PDK-1, and L-LDHA (XREF_FIG)."
33796579
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"Increased phosphatidylinositol 3-kinase (PI3K) and AKT or decreased PTEN activity in prostate cancer cells also increases HIF-1alpha expression by an undefined mechanism."
11359907
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"However, in tumors not undergoing RFA treatment, PI3K and Akt signaling may directly regulate HIF-1alpha expression, while heat induced HSP70 is not involved."
27278081
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"Blocking PI3K and AKT or mTOR activity strongly diminished hypoxia induced HIF-1alpha expression and VEGF secretion in T24 cells, supporting the involvement of PI3K/AKT/mTOR in the induction of HIF-1alpha and VEGF."
26193287
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"A number of recent studies have demonstrated that Akt and mTOR up-regulates HIF-1alpha expression, and stabilizes HIF-1alpha, and increases HIF-1alpha synthesis in various cells including cancer cells under normoxic and hypoxic conditions [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Additionally, T3 induced PI3K and Akt signaling leads to increased expression of HIF-1alpha in several cell types, such as hepatoma cells, primary human hepatocytes, kidney and lung carcinoma cells, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28974422
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"The activation of the PI3K and Akt signaling pathway, not only controls VEGF stimulated cell proliferation and migration, but has been reported to modulate the expression of VEGF and HIF-1alpha (Jiang[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23022044
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"In prostate and gastric cancer cells, AKT contributes to HIF-1alpha expression and accumulation XREF_BIBR, XREF_BIBR."
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"Moreover, constitutively active AKT could increase basal expression levels of HIF-1alpha protein in DLBCL cells."
24312289
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"The expression and activity of HIF-1alpha is also reportedly enhanced by AKT signaling under both normoxic and hypoxic conditions."
32377733
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"PI3K and AKT pathway activated by ROS increases HIF-1alpha expression and prevents its degradation through increased heat shock protein expression and nitric oxide synthase activation via phosphorylation XREF_BIBR, XREF_BIBR."
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"Collectively these results suggest that AKT activates HIF-1alpha protein expression in DLBCL cells to the extent that HIF-1 is protective and its suppression by PCI-24781 could induce apoptosis."
24312289
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"Akt can augment HIF-1alpha expression by increasing its translation under both hypoxic and normoxic conditions [XREF_BIBR]."
22988500
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"In the present study, we show that high glucose initiates the PI 3 kinase and Akt signaling cascade to drive the expression of Hif1alpha via activation of PDGFRbeta."
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"Furthermore, the AKT and mTOR signals lead to increased expression of HIF-1alpha and subsequent angiogenic factors including VEGF and PDGF [XREF_BIBR, XREF_BIBR]."
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"In mammalian cancer cells, it is known that the PI3-kinase and AKT signaling axis can lead to elevated HIF-1alpha protein levels under normoxic conditions and that this pathway is sensitive to antioxidant administration (Liu etal., 2011; Kilic-Eren etal., 2013)."
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"Activation of AKT has been shown to increase HIF1alpha expression in normoxic conditions (XREF_FIG)."
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"Lin et al. [XREF_BIBR] found that the inhibition of PI3K and Akt signaling by andrographolide significantly suppressed the protein and mRNA levels of HIF-1alpha, as well as the protein level and transcriptional activation of VEGF in A549 cells."
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"Akt can augment HIF-1alpha expression by increasing its translation [XREF_BIBR]."
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