IndraLab

Statements

TP53 binds MDM2 and NUMB. 12 / 12
| 1 11
sparser
"Our results reveal a previously unknown molecular mechanism that Numb can migrate into the nucleus and interact with HDM2 and p53."
32501652
sparser
"HBeAg and its precursors could disrupt p53-NUMB and HDM2-NUMB interactions and tricomplex p53-HDM2-NUMB formation, inhibit the acetylation and translocation of p53 from cytosol to the nucleus, promote HDM2-mediated ubiquitination and degradation of p53, and suppress p53-dependent apoptosis."
27106262
reach
"In addition, the tumor suppressor role of Numb was demonstrated to be associated with the formation of the Numb, TP53, and MDM2 complex."
25788995
sparser
"Mechanistically, NUMB forms a ternary complex with MDM2 and TP53 and inhibits the activity of MDM2 ( xref , xref )."
30515368
sparser
"Among these regulators, Numb is most similar to TSC-22 because Numb binds to p53 and HDM2, thereby preventing ubiquitination and degradation of p53 xref ."
22870275
sparser
"For example, Numb forms a tripartate complex with p53 and mdm2 and in so doing stabilizes p53 against ubiquitination and proteasomal degradation (Colaluca et al. xref )."
29333723
sparser
"Numb forms a tricomplex with p53 and its negative regulator, MDM2."
23140583
sparser
"This study also reported that Numb forms a tricomplex with p53 and MDM2."
25788995
sparser
"Recent evidence has demonstrated that TCTP can facilitate Mdm2-mediated ubiquitination of P53 by competing with and preventing the binding of Numb, an inhibitor of Mdm2, to the Mdm2-P53 complex [ xref ]."
31935927
sparser
"Apart from promoting asymmetric cell division, NUMB associates with p53 and MDM2 in a tricomplex preventing ubiquitination and degradation of p53 ( xref )."
33505918
sparser
"Although MDM2 is responsible for the ubiquitination and degradation of NUMB [ xref ], when NUMB simultaneously binds p53 and MDM2, p53 degradation is inhibited [ xref ]."
19538162
sparser
"Lately, it was found that NUMB can form a tricomplex with p53 and its negative regulator MDM2 which prevents its degradation [23] ."
21939656