IndraLab

Statements

CYLD-R324A inhibits ROCK. 2 / 2
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"Because microtubule disruption has been linked to release of at least two Rho GEFs, Trio and RhoGEF-H1 (Birukova et al., 2006; Krendel et al., 2002; Mikelis et al., 2015; van Haren et al., 2014), whic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Because microtubule disruption has been linked to release of at least two Rho GEFs, Trio and RhoGEF-H1, which subsequently activate ROCK, we sought to test whether the non cleavable R324A CYLD mutant can also suppress ROCK kinase activity following thrombin treatment."
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