IndraLab

Statements

IL6 decreases the amount of IRS1. 9 / 9
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"In vitro, IL-6 inhibits gene transcription of IRS-1, GLUT4, and PPARgamma and reduces insulin stimulated glucose uptake in 3T3-L1 adipocytes."
24918199
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"Both IL-6 and TNF may inhibit the transcription of IRS-1 and glucose transporter (GLUT) -4 genes, thus reducing glucose transport and enhancing insulin resistance in obese patients [XREF_BIBR]."
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"Long-term IL-6 or TNF-alpha treatment inhibits the expression of GLUT4 and IRS-1 in adipose tissue, and in obese patients with T2DM, lower levels of GLUT4 and IRS-1 in VAT were observed."
29967759
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"In addition, Rotter et al. [37] showed that IL-6 may inhibit transcription of the IRS-1 (insulin receptor substrate 1), GLUT-4 (glucose transport type 4), and peroxisome proliferator activated recepto[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TNF-alpha and IL-6 can cause insulin resistance by suppressing expression of the insulin receptor substrate -1 (IRS-1) and GLUT-4 though activation of NF- K B pathway [XREF_BIBR, XREF_BIBR]."
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"Specifically, IL-6 treatment reduced adiponectin, resistin, glucose transporter type (GLUT)-4, and IRS-1 expression; while TNF-alpha treatment increased secretion of IL-6 and MCP-1 from pre-adipocytes."
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"IL-6 can suppress the expression of IRS-1 and Akt phosphorylation in HepG2 cells XREF_BIBR."
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"As shown in Fig. 2, IL-6 decreased the protein expression of IRS-1 and IR-beta, without modification of the protein expression of ERK1/2 and Akt and PKB."
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"IL-6 and TNF-alpha can reduce the expression of GLUT4 and IRS-1, and reduce the glucose transport [XREF_BIBR]."
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