IndraLab

Statements


RAS bound to RAF1 activates ERK. 3 / 3
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"In- deed, an effector domain mutant of oncogenic Ha- Ras (V12) that can not bind Raf-1 and activate the ERK cascade, Ha-Ras (V12; E37G), is nontransforming (White et al., 1995)."

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"The proposed mechanism for this suppressive action of Rap1 is competitive inhibition of interactions between Ras and Raf-1, thereby blocking the activation of Erks."

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"By contrast, V12S35 Ras bound Raf-1 in vitro and stimulated activation of Raf-1, ERK, and Elk,1 [45]."