IndraLab

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RAS bound to GTP activates ERK. 3 / 3
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"Mutant RAS-GTP enhances BRAF V600E dimerization, reactivates the ERK pathway and confers resistance to BRAF inhibitors since these drugs only block monomeric BRAF V600E [XREF_BIBR]."
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"Early experiments using the immortalized Jurkat T cell line showed that overexpression of DGKzeta inhibits TCR signaling by reducing the levels of active GTP bound Ras and, consequently, diminishing ERK activation."
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"20-25 In particular, RAS-GTP has been found to activate the RAF --> mitogen activated protein kinase (MEK) --> extracellular signal regulated kinase (ERK) pathway, which often is referred to as the MA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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