IndraLab

Statements

RAS-V12 activates ERK. 6 / 6
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"Mechanism study showed that PDHB inhibited ERK signaling and cell growth driven by RasV12."
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"However, alpha3beta1 was not required for RasV12 mediated activation of ERK or for ERK dependent MMP-9 promoter activity."
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"RanBPM was found to inhibit MEK and ERK activation induced by ectopic expression of active RasV12."
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"PME-1 depletion inhibited ERK pathway activity induced by RasV12, whereas cells expressing constitutively active alleles of either B-Raf or MEK, were found resistant to PME-1 shRNA (XREF_FIG, XREF_FIG)."
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"As shown in Fig. 6C, RasV12 and Rac1V12 and Cdc42V12 activated ERK and JNK pathways, respectively [48,49]."
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"It has been shown that the oncogenic Ras mutant, RasV12, activates ERK1/2 strongly, and that the constitutively active MEK5 mutant, MEK5D, selectively activates ERK5 XREF_BIBR, XREF_BIBR."
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