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SRC phosphorylates TIAM1 on Y384. 9 / 10
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"Here, we show that Tiam1 is phosphorylated on Y384 by Src."
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"We found that Tiam1 constitutively forms a complex with ERK, and this Tiam1 associated ERK is only activated when Tiam1 is phosphorylated on Y384 by Src."
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"To establish whether endogenous Src family kinases (SFKs) phosphorylate endogenous Tiam1 on Y384, we treated H293T cells with sodium pervanadate (PV), an irreversible protein-tyrosine phosphatase inhi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here, we show that Tiam1 is phosphorylated on Y384 by Src."
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"This interaction required both the typical binding pocket of the Grb2 SH2 domain ( Figure S5 A) and Src-induced phosphorylation of Tiam1 on Y384 ( Figure 4 B)."
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"We found that Tiam1 constitutively forms a complex with ERK, and this Tiam1-associated ERK is only activated when Tiam1 is phosphorylated on Y384 by Src."
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reach
"To establish whether endogenous Src family kinases (SFKs) phosphorylate endogenous Tiam1 on Y384, we treated H293T cells with sodium pervanadate (PV), an irreversible protein-tyrosine phosphatase inhi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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reach
"Together, these data support our previous findings that phosphorylation of Tiam1 at Y384 is induced by Src activity and is associated with reduced total Tiam1 levels.Here, we have shown that Tiam1 is [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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reach
"Here, we show that Tiam1 is phosphorylated on Y384 by Src."
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