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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RHEB bound to MTOR activates MTOR. 2 / 2

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"Rheb interacts directly with mTOR and activates mTOR kinase, whereas Rabin8 interacts with Rheb and inhibits the phosphorylation of Ser235 and Ser236 in small ribosomal subunit protein S6."

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"There is some evidence indicating that Rheb, a small guanosine triphosphate (GTP)-binding protein, interacts with mTOR and activates the enzymatic activity of mTOR by binding the Rheb-GTP to mTOR directly."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...