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"For example, EGFRvIII phosphorylates SFKs, which further activate dedicator of cytokinesis 1 (DOCK1). xref DOCK1 plays critical roles in mediating cell growth and migration, contributing to the pro-tumorigenic function of EGFRvIII. xref , xref EGFRvIII can also increase phosphorylation of DOCK1 through PKA. xref EGFRvIII forms a complex with the cytokine receptor OSMR, which regulates the EGFRvIII-STAT3 signaling axis. xref Additionally, SFK activation promotes mitochondrial localization of EGFRvIII, and increases cell survival under low glucose conditions. xref Moreover, EGFRvIII activates hepatocyte growth factor receptor (MET), which in-turn drives STAT3. xref , xref EGFRvIII also activates c-SRC, which promotes secretion of vascular endothelial growth factor (VEGF) and angiogenesis. xref Phosphorylation of these kinases further activates downstream signaling pathways and contributes to tumor progression."