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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active SRC leads to the phosphorylation of AKT1 on S473. 1 / 1

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"In cells under static conditions low levels of Akt (Ser473) and eNOS (Ser1177) phosphorylation were detected and the application of shear stress (12 dynes cm–2, 30 minutes) was associated with the phosphorylation of Akt as well as that of eNOS (Fig. 3B). The Src-family tyrosine kinase inhibitor PP1 (30 μmol l–1) markedly attenuated the phosphorylation of Akt and eNOS while the inactive compound PP3 failed to affect the response to shear stress."

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...