IndraLab

Statements

CYLD inhibits Interferon. 10 / 11
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"Ectopic expression of CYLD inhibits the IRF3 signalling pathway and IFN production triggered by RIG-I; conversely, CYLD knockdown enhances the response."
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"The deubiquitinating enzyme CYLD cleaves K63 linked polyubiquitin chains from specific substrates, including tumor necrosis factor receptor associated factors (TRAF)-2, TRAF6, transforming growth factor beta activated kinase 1 (TAK1), B cell lymphoma 3 (BCL3), STAT3, nuclear factor kappa B essential modulator (NEMO), and retinoic acid inducible gene 1 (RIG-1), and negatively regulates the activation of NF-kappaB, MAPKs, and type I IFN production."
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"Since CYLD negatively regulates IFN induction, XREF_BIBR, XREF_BIBR we examined whether the loss of CYLD renders mice more resistant to viral infection."
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"First, individually KO of CYLD, caspase-8, and FADD (required for caspase-8 activation) in HeLa cells (Fig. 3 A) and KO of CYLD and caspase-8 in HCT-116 cells (Fig. 3 B) blocked TNF/IFNγ-induced cell death."
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"Strikingly, the CYLD and TRAF3 genetic alterations affected mutually exclusive HPV+ HNSCC tumor groups, suggesting that alterations in either TRAF3 or CYLD may function independently and sufficiently to deregulate the downstream NF-kappaB and IFN responses."
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"Consistent with this, IRF1 bound to the promoter regions of caspase-8 and CYLD, and IFN-stimulated response elements (ISREs) were identified whereby CRISPR/Cas9-mediated mutation of these caspase-8 and CYLD ISREs prevented IFNγ-induced caspase-8 and CYLD expression (Fig. 1)."
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"For example, USP3 and CYLD were reported to negatively regulate type I IFN induction by targeting RIG-I ( Cui et al., 2014 ; Friedman et al., 2008 ); OTUD1 potently inhibits innate antiviral immunity [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Several DUBs were shown to have an inhibitory effect on the RIG-I signalling pathway (Fig XREF_FIG), as for example knockdown of CYLD enhanced type-I IFN production in response to SeV infection whereas ectopic CYLD expression inhibited it XREF_BIBR."
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"For example, lncRNA AANCR was found to promote MITA expression during Siniperca chuatsi rhabdovirus (SCRV) infection by competitively binding to miR-200, thus establishing a ceRNA network, and lncRNA CYLD reversely inhibits type-I interferon through ceRNA mechanism in bovine viral diarrhea virus (BVDV) infection ( xref , xref )."
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"For example, CYLD removes polyubiquitin chains from TBK1 and RIG-I and thus inhibits the IRF3 signaling pathway and IFN production triggered by RIG-I; conversely, CYLD knockdown enhances this response (58)."
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