IndraLab

Statements

COPS5 activates cell growth. 11 / 13
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"XREF_BIBR used T83 (a new 4-arylidene curcumin analogue) to inhibit the expression of Jab1 in NPC cells, demonstrating that inhibition of Jab1 could reduce tumor cell growth, induce G 2 / M arrest, and increase tumor cell apoptosis, thus enhancing the sensitivities of NPC cells to radiotherapy."
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"Animal studies have verified that troglitazone decreases Jab1/CSN5 expression and suppresses HCC cell growth in tumor tissues ."
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"Recently, a prior study has demonstrated that CSN5-mediated stabilization of survivin promotes non-small cell lung cancer cell growth [ 27 ]."
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"Besides extracellular functions, MIF is known to bind to intracellular protein targets such as Jun-activated domain-binding protein 1 (JAB1), which results in slowing down JAB1 mediated cell growth [ [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In HCC, abnormal expression of JAB1 can significantly reduce CDKN1C and p57 levels and promote tumor cell growth."
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"JAB1 promoted ESCC cell growth The CCK-8 assay revealed that the Eca109 and EC9706 cells transfected with the JAB1 overexpression lentivirus showed significantly increased absorbance compared to normal cells , ( Fig 3a ) ."
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"Knockdown of COPS5 and COPS6 inhibited cell growth and migration of the CAL27 and SCC25 cell lines."
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"Jab1 and CSN5 promotes NPC cell growth."
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"JAB1 silencing with each of our the 4 constructs in the above PCa cell lines arrested cell growth and/or promoted their death."
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"We also found that CSN5 silence inhibited cell growth by inducing cell cycle arrest and apoptosis promotion in NSCLC cells."
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"Similar to AR-positive PC cells , inhibition of CSN5 repressed cell growth ( Fig. 4A ) ."
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