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Statements

TNF activates ERK. 639 / 664
1 | 3 4 431 200
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"Mechanistically, MADD siRNA inhibited TNFα induced activation of pERK, pGSK3β and β-catenin, suggesting that MADD knockdown might exert its anti-migratory/invasive effects, by blocking TNFα/ERK/GSK3β axis."
30760700
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"Our previous results show that TNF-alpha activation of ERK signaling leads to stabilization of the TGF-beta 1 mRNA in lung fibroblasts [XREF_BIBR]."
20141610
sparser
"In marked contrast to these findings for cell lines and neutrophils, GM-CSF, IL-3, and TNF did not induce tyrosine phosphorylation and enzymatic activation of both ERK and p38 in normal human monocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10378896
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"beta-arrestin 1 can function as a signaling molecule in the TNFalpha action cascade that stimulates ERK activation and lipolysis, mediates phosphatidylinositol 3-kinase activation and inflammatory gene expression 60."
23764061
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"TNF-alpha stimulation activated the ERK1/2 pathway, but did not significantly affect p38 and JNK phosphorylation levels."
29467899
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"In a model of chronic low-grade inflammation, palmitate-induced production of TNFα and IL-6 in macrophages was inhibited by vitamin D treatment, which appeared to be due to a reduction of palmitate-stimulated JNK and ERK1/2 activation [71]."
33851285
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"Nevertheless, tumor necrosis factor (TNF-alpha), the major proinflammatory cytokine in IBD, increases intestinal permeability and will result in the rapid activation of ERK1/2 and a myosin light chain kinase dependent opening of intestinal TJ [XREF_BIBR]."
27164138
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"L929 cells overexpressing hPEBP4 are resistant to both TNFalpha induced ERK1/2, MEK1, and JNK activation and TNFalpha mediated apoptosis."
15302887
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"In ASM cells, MAPKs mediate changes in the profile of gene expression through phosphorylation of intracellular proteins including transcription factors, and TNF-alpha causes activation of the MAPKs, that is, p38, JNK, and ERK1/2, resulting in the regulated expression of a variety of genes involved in excitation-contraction coupling [XREF_BIBR - XREF_BIBR]."
29576747
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"TNF-α induced transient ERK activation and SAC treatment resulted in sustained ERK activation both in the presence and absence of TNF-α."
31535738
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"TNF-alpha induced calcific response in VIC activated myofibroblasts involves MAPK/ERK signaling."
33554387
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"Of importance, the p38 inhibitor SB203580 prevented TNF-α–induced TACE activation ( xref ), as well as TNF-α-induced ERK activation ( xref )."
23389627
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"TNFalpha induced ERK 1/2 activation in both cell types."
11689211
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"Furthermore, we provide evidence that the TNF-dependent activation of ERK and cPLA(2) requires the intact death domain of TNF-R55."
10913368
sparser
"However, this "canonical TNF-α signaling" does not explain how ERK, AKT, and STAT3 can be activated by TNF-α."
32159413
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"TNF-α activated ERKs, in the absence or presence of IGF-I ( Fig. 1A )."
11277995
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"In vivo, overexpression of TNF induced activation of p38MAPKalpha and ERK in the synovial membrane, whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis."
16207331
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"PF inhibited TNFα-stimulated adipocyte lipolysis in a dose-dependent manner, which was compatible with suppressed phosphorylation of TNFα-activated ERK1/2 and preserved downregulation of perilipin."
19396840
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"TNF-alpha activated ERK1/2, JNK, and p38 maximally at 15 min in HUVEC."
12686737
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"Indeed, published studies indicate that TNF activates ERK [XREF_BIBR] in fibroblast like synoviocytes and Akt in normal human FS-4 dermal fibroblasts [XREF_BIBR]."
26198031
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"In cells both at passages 1 and 4, TNF-alpha downregulated NO synthase and up-regulated p-Erk 1/2 protein."
19010548
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"Furthermore, phosphorylation of p65, IkappaBalpha, IkappaBbeta, ERK1/2, and JNK1/2, was increased in HCT116 cells treated with TNF-alpha."
28125661
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"In the present study, we confirmed that TNF-alpha activates NF-kappaB and the ERK1/2 and p38 MAPK signaling pathways in A549 cells."
23142559
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"The TNFalpha induced activation of ERK1/2 was specifically prevented by compound PD 98059 a specific inhibitor of the MAP kinase kinase MEK1/2."
11478736
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"Since TNFα was able to activate Akt, ERK and P38 MAPK simultaneously, we next sought to determine which of these pathways are responsible for the regulation of synthesis and secretion of TSP-1 by the hMEC."
25963668
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"TNF-alpha activated the ERK MAP kinase, and ERK activity was essential for chemokine gene expression."
17704189
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"TNF signalling activates MAPK and ERK which performs multiple downstream functions [XREF_BIBR, XREF_BIBR]."
29746601
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"It can therefore be assumed that IL-21 promotes the secretion of IL-6 and TNF-α by activating respectively the STAT3, ERK1/2, and Akt in RA-FLS, and inhibition of these pathways could be a future direction of arthritis research [28]."
33515210
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"This result indicates that TNF α -mediated activation of ERK1/2 is dependent on NF- κ B activation."
23412386
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"Our results further demonstrate that GRK2 inhibits TNFalpha induced ERK activation by inhibiting generation of reactive oxygen species (ROS)."
28572156
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"TNF-alpha triggers the activation of Ras, p38 MAPK, ERK1/2, SAPK and JNK, HMGB1 and TLR4, and Akt pathways, and ultimately, the expression of proinflammatory cytokines, cellular proliferation, and migration."
34054510
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"We showed that UA inhibited TNFα-induced activation of JNK, ERK, and Akt."
30283339
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"As such, the TNFalpha activation of ERK1/2 likely contributes to the initial, pro angiogenic phase of AIMP1 and EMAP II signaling."
25535072
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"Therefore, we have analyzed TNF-induced ERK activation in various human and murine cell lines and show that it occurs in a cell-type-specific manner."
16129431
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"Analysis of embryonal fibroblasts from FAN knockout mice revealed that TNF-induced activation of both ERK and cPLA(2) occurs without involvement of FAN."
10913368
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"TNF mediated ERK but not p38 MAPK recruitment to p47phox was delta-PKC-dependent."
19801500
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"TNFalpha also activated ERK1/2."
16141211
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"Indeed, unlike other cytokines and growth factors-mediated activation of ERK and AKT we studied, the level of TNF α -induced activations of ERK and AKT are always modest."
33907493
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"In contrast to the TNF-α–induced ERK activation, however, the effect of depolarization was not affected by Rac silencing, suggesting that Rac does not mediate ERK activation by all stimuli but is specific for the TNF-α–induced pathway."
23389627
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"In comparison, HaCaT cells stimulated by TNF-α only activated ERK significantly, but JNK and P38 were not activated."
32349358
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"Currently, the main analgesic mechanism of curcumin is thought to involve signals such as tumor necrosis factor-α (TNF-α), nitric oxide (NO) [6], and extracellular signal-regulated kinase (ERK) [7] in the anti-inflammatory pathway."
33532012
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"TNF-alpha induced transient ERK activation and SAC treatment resulted in sustained ERK activation both in the presence and absence of TNF-alpha."
31535738
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"However, a recent report showed that TPL2 catalytic activity can regulate TNFalpha production independently of ERK activation [XREF_BIBR]."
24647229
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"These data indicate that the observed increase in TNF production from human skin mast cells pre-treated with 10 microM Resveratrol (XREF_FIG) was not due to an increase in FcepsilonRI induced activation of Akt, p38 or p42/44."
26777630
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"Moreover, activation of ERK1/2 by TNFalpha in rat hepatcoytes was not significant and ERK1/2 activation was not decreased in TNF knockout mice compared to wild mice after LPS treatment."
21790671
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"To verify that CO2 directly activated ERK1/2 in ECs, we showed that ERK1/2 were still activated by CO2 in the presence of MEK1/2 inhibitors (U0126 and PD98059), while activation of ERK1/2 by TNFα was abolished under these conditions (Fig. 1e)."
34741187
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"The involvement of this nucleoside in the activation of ERK 1/2 by TNF-alpha was also investigated."
15979106
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"We further demonstrate that Egr-1 induction is triggered by TNF-α– dependent ERK activation, and inhibition of this pathway ablates Egr-1 expression."
19786304
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"It is well known that TNF-alpha induces the activation of ERK1/2 in multiple cell types including myoblasts and the activation of ERK1/2 pathway is directly linked to skeletal muscle insulin resistance XREF_BIBR XREF_BIBR."
26468734
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"TNFalpha also caused transient stimulation of p38MAPK and ERK1/2 in hCMEC/D3 cells, and the occludin band-shift induced by TNFalpha was suppressed by SB202190, an inhibitor for p38MAPK, and partly by U0126, the MEK1/2-ERK 1/2 inhibitor."
28170408
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"We found that phosphor-ERK1/2 significantly increased after a 12 h treatment of TNF-alpha or a combination of TNF-alpha and Adv-BMP2, suggesting that TNF-alpha significantly activated the ERK pathway in C2C12 cells."
29435145
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"Our results demonstrate that beta-arr1 has a critical role in modulating ERK, JNK and p38 MAPK pathways mediated by TNF-alpha in IECs."
26479868
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"In this study, PTX was found to downregulate the phosphorylation of TNF-α induced ERK1/2 and JNK; however, p38 expression was not significantly changed."
34566640
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"LPS, IL-1beta, and TNF-alpha, which mediate ocular inflammation, stimulate activation of p38, ERK, and Akt kinases in the corneal cell line."
16760261
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"Consistent with the activation of the bZIP factors, the main MAP kinases (extracellular signal-regulated kinase [ERK], p38, and JNK) were activated by TNF in the presence or absence of IL4+IL13 (Fig 6F)."
35027468
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"Jun N-terminal kinase and extracellular regulated protein kinases are easily activated by TNF, IL, and ROS, as well as metabolic syndrome, and both play important roles in various processes of physiology and pathology ( xref )."
34249992
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"We also identified the presence and colocalization of TNFalpha, activated ERK 1/2 and the transcription factors Ets-1, Egr-1 and c-fos in VSMC and macrophages in vascular lesions."
11689211
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"Therefore, we next investigated the possibility of an antagonistic action of glucocorticoids on the activation of ERK signalling pathways.Dex inhibited (2-3-fold) ERK activation by TNFalpha or VEGF in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10518034
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"Omegaven (TM) decreased IL-1 and TNF-alpha mediated ERK1/2 signaling (0.49 fold +/-0.09, p < 0.05 and 0.22 +/-0.05, p < 0.05) compared to control."
28433363
sparser
"Neither JNK1 activation by IL-1beta or UV nor TNF-alpha-induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1."
19815509
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"In contrast, AKT and ERK1/2 signaling pathways were not activated by IL-17 or TNF-alpha in LNCaP cells."
28223102
sparser
"IL-1 beta and TNF-alpha activated extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase/stress-activated protein kinase, and p38 mitogen-activated protein kinase."
12131776
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"TNFalpha is a pleiotropic regulator of these cellular functions and is known to induce ERK 1/2 activation through p55 TNFalpha receptor mediated signaling in macrophages [9,10,23-25]."
11689211
sparser
"TNF rapidly activated extracellular signal-regulated kinase and p38 mitogen-activated protein kinases, but neither of these pathways was critical for MMP-9 release."
16275891
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"TNF-α also activates the Hif-1α/ VEGF/ VEGFR-2/ ERK signaling pathway to decrease the expression of occludin in human cerebral microvascular endothelial cell lines [60]."
34529552
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"RNAi studies showed that MLK3 promotes microtubule instability, is required for cell proliferation in colon epithelial and lung fibroblast cells, and is required for activation of ERK and SAPK/JNK by TNF and EGF [ xref , xref ]."
19586614
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"We recently showed that TNF-alpha rapidly activates the ERK signalling pathway resulting in stabilization of TGF-beta 1 mRNA [17]."
20141610
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"We therefore asked whether HER2, in association with EGFR, participates in TNF-alpha stimulated ERK activation."
22988345
sparser
"Recombinant PGRN or transfection of a cDNA encoding PGRN did not antagonize TNF-dependent NFκB, Akt, and Erk1/2 pathway activation; inflammatory gene expression; or secretion of inflammatory factors in BV2 microglia and bone marrow-derived macrophages (BMDMs)."
23699531
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"MAPK signaling, including JNK, ERK1/2 and p38 MAPK, which can be activated by LPS and TNF-alpha, is reported to play an important role in LPS induced inflammation [XREF_BIBR]."
27191745
sparser
"A previous study also showed that TNFα activated both p38 and ERK1/2 in human neutrophils, but that only activation of ERK1/2 was necessary for TNFα-mediated inhibition of caspase-3 activity and the pro-survival effect ( xref )."
32373107
sparser
"To this end we have employed the dominant-negative SK to demonstrate that TNFalpha activation of extracellular signal-regulated kinases 1 and 2 (ERK1,2) is dependent on SK activation."
10944534
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"TNF-alpha activated ERK and increased NF-kappaB promoter activity."
20049872
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"Correspondingly, the results of scratch assay, transwell, migration and invasion all proved that the migration and invasion ability of glioblastoma U251 and U87 cells were significantly enhanced, which indicated that TNF-α promoted the activation of NF-κB and ERK pathway, and in turn promoted the migration and invasion ability of glioblastoma cells."
32742812
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"TNF-alpha treatment caused an increase in c-Jun N-terminal kinase (JNK), p38 mitogen activated protein kinase (p38 MAPK), and extracellular signal regulated kinase (ERK) activities, whereas PDGF treatment caused an increase in ERKs and p38 MAPK activities without any effect on JNK activity."
11116048
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"TNF-alpha caused activation of ERK signal pathway, and U0126 suppressed this effect induced by TNF-alpha."
24370050
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"Our results suggest that TNF-alpha significantly activated the ERK signal in C2C12 cells and modestly activated p38, but not JNK."
29435145
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"In this study we demonstrate the expression and colocalization of TNFalpha, activated ERK 1/2, and the transcription factors Ets-1, Egr-1 and c-fos in VSMC of rat neointimal lesions and in macrophages[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11689211
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"Effects of Digibind on TNFalpha induced extracellular signal regulated kinase and Na + / K + -ATPase expressions were also examined."
19148111
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"In contrast, tumor necrosis factor alpha- or interleukin-1 and Toll-like receptor signaling molecules-such as mitogen activated protein kinase and extracellular signal regulated kinase kinase 1, MyD88, and interleukin-1 receptor associated kinase-did not play a role in RANTES activation by H. pylori."
12819056
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"Since TNF activates the ERK pathway in colon epithelial cells, we tested the biological effects of KSR1 in the survival response downstream of TNF."
21144847
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"We found that in C2C12 myotubes, TNF-alpha activated JNK (Jun N-terminal kinase), ERK (Extracellular signal regulated kinase) and p38 MAPKs and MSK-1 (XREF_FIG)."
24603712
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"Jijon HB et al. reported that TNF-α induced ERK and EGFR activation [29] and Andrianifahanana M et al. reported that TGF-β induced EGFR activation [30]."
23651618
sparser
"In contrast, however, lipid rafts have been reported for TNF receptor 1 (TNFR1)-initiated activation of NF-κB and ERK1/2 [ xref , xref ]."
19432816
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"These data suggest that the ERK and JNK pathways are activated by TNFalpha in HaCaT cells.To determine the functional role of the ERK and JNK MAPKs in TNFalpha induced EGR-1 expression, we utilized ph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18675783
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"In a recent report by XREF_BIBR, tight junction permeability of Caco-2 cell monolayers, in an in vitro model of intestinal epithelium, was increased by TNF-alpha activation of the ERK1/2 signaling pathway."
28588494
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"In airway epithelial cell line Calu-3, TNF-alpha induces ERK1/2 activation and dissociation of ZO-1 and occludin, together with a concomitant drop in TER [53]."
26148935
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"We observed that IL-18BPa-Fc reduced activation of the ERK1/2 pathway induced by TNF-alpha."
20131228
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"Collectively, these data suggest that monocytes and macrophages in liver metastases induced tumor cell proliferation, migration and invasion, and upregulated S100a8 and S100a9 expression through TNFalpha induced ERK activation."
27086923
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"To further address precise mechanism by which UCH-L1 suppresses TNFalpha mediated activation of ERK will provide novel insight into the understanding of TNFalpha mediated inflammatory responses in VSMCs, facilitating development of new therapeutic approaches for the treatment of vascular diseases."
19945429
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"In the present study, we found that ERK-1/2, p38-kinase, and JNK can be activated by TNF-alpha itself, but that CD83 up-regulation is related with the ERK-1/2 pathway in the presence of other stimuli,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15454113
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"In one mechanism, TNF-alpha activates two different MAP kinases, i.e., ERK and p38, through distinct pathways that promote the downstream activation of cyclic AMP responsive element binding protein (CREB)."
33572760
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"It has been shown that TNFalpha activates p38 and ERK MAPKs in the synovial macrophages."
21133840
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"Previous studies showed that TNF-alpha stimulates ERK activation through EGFR dependent or -independent pathways, and that EGFR independent ERK activation is mediated through the activation of transforming growth factor-beta-activated kinase 1 and tumor progression locus 2 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
33096942
sparser
"In this study, we examined the effects of KSR deficiency on ERK activation by stress stimuli and show that ERK activation by TNF, IL-1, and sorbitol is attenuated in the absence of KSR1."
17056543
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"This observation raises the possibility that MMP9 expression can be promoted through TNFalpha induced ERK activation when WASF3 levels are repressed."
21544801
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"We found that under such conditions, BMP-2 and TNF-alpha and IL-1beta induced the activation of the p38 and ERK1/2 signaling pathways and played opposing roles in the regulation of Runx2 expression and osteoblastic differentiation."
24743742
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"We found that TNF activated ERK1/2 in a time dependent manner (XREF_FIG) and was sustained up to 10 hrs following TNF treatment."
18266953
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"Furthermore, forced expression of Adrx decreased TNFalpha induced activation of ERK1/2, JNK, p38 and IKKs in HUVECs."
27941911
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"Since Map3k8 D270A mutation substantially reduced TNF activation of ERK1/2 and p38alpha, it was expected that MSK activation would be similarly impaired."
27402796
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"TNFα-induced ERK activation was suppressed in rheumatoid FLS with overexpression of Raf kinase inhibitor protein ( Ahn et al., 2012 ), suggesting that in RA FLS suppression of Raf activation can negat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26265114
sparser
"To verify that CO2 directly activated ERK1/2 in ECs, we showed that ERK1/2 were still activated by CO2 in the presence of MEK1/2 inhibitors (U0126 and PD98059), while activation of ERK1/2 by TNFα was abolished under these conditions (Fig. 1e)."
34741187
sparser
"In the signaling pathway of MIF (macrophage migration inhibitory factor) regulation of innate immunity, activation of CD74 and ERK1/2 genes induced by TNF-α were also altered by the pre-treatment of α-tocopherol."
22267916
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"To further verify the role of ACSL1 in TNFα induced activation of p38 MAPK, ERK1/2, and NF-κB signaling proteins, we transfected MDA-MB-231 cells with ACSL1 siRNA and scramble siRNA prior to TNFα treatment."
31581558
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"Indeed, we have shown here that Cot regulates the expression of IL-8 and MIP-1beta, two chemokines that play an important role in the development of inflammation.Meanwhile this manuscript was in prepa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16371247
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"PKCdelta regulates TNF mediated ERK activation and the NADPH oxidase in neutrophils (this study and."
30095599
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"In H9c2 cells, E2 or ERalpha agonist attenuated TNF-alpha- or staurosporine-induced decreases in BMPR2, apelin, and phospho-ERK1/2 (p<0.05 for all endpoints)."
| PMC
sparser
"Moreover, the extract of C. sudachi peel also suppressed TNF-α-induced ERK pathway activation, although TNF-α did not affect EGFR phosphorylation on Tyr-1068."
33096942
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"As a result, generation of the N-terminal fragment of GAB1 further induces sustained activation of ERK1/2 MAPK and consequent enhancement of viral replication."
28361043
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"Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase (ERK), p38 MAPK, and c-Jun N-terminal kinase activity in a rapid and transient manner, whereas interferon-gamma (IFN-gamma) can induce only ERK."
10601128
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"Eicosanoid signaling is upregulated by lipopolysaccharide (LPS), pro inflammatory cytokines interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha, nuclear factor kappa-B (NF-kappaB), and mitogen activated protein kinases (MAPK) p38, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinases (JNK), all of which are all important mediators of neuroinflammation [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23709104
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"The idea that TNF induced activation of ERK and/or cPLA 2 is coupled to the DD of TNFR1 is in agreement with recent observations from other investigators : (i) Boone et al. showed by analyzing TNFR1 m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12401196
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"The extracellular signal regulated kinase (ERK) and nuclear factor-kappaB (NF-kappaB) signal pathways were activated by TNF-alpha."
24802761
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"ERK1/2, which is involved in the regulation of cell proliferation, differentiation, and motility 42, can also be activated by TNF-alpha, and the ERK1/2 pathway is critical for transducing TNF-alpha signaling to increase matrix metalloproteinase production in trabecular meshwork cells 43."
29622770
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"EGF activated IkappaB, Akt and Erk whereas TNF activated only IkappaB and reduced EGF activated Akt and Erk in these cells."
23800251
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"TNF alpha also produces a small and transient increase in extracellular signal regulated kinase (ERK) activity and no measured increase in Raf-1 kinase activity."
7929360
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"The extracellular signal regulated kinase 1/2 (ERK1/2) pathway is activated by TNFalpha and IFNgamma in some cell types and is upregulated in lung tumors [XREF_BIBR - XREF_BIBR], Herein we examine ERK1/2 dependent signaling events in TNFalpha and IFNgamma mediated inflammatory responses by comparing prostaglandin and NO production with cell proliferation in non transformed and tumor derived mouse lung epithelial cell lines using a small molecule inhibitor of MEK1/2 (U0126), an upstream kinase that phosphorylates and activates ERK1/2."
20815659
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"TNF-alpha also activated NF-kappaB, AP-1 and ERK1/2."
16094077
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"Similarly, activation of extracellular signal-regulated kinase (ERK) and JNK by TNF was practically indistinguishable between WT and Dapk1 − /−BMDMs."
32366830
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"TNF-α-induced ERK and JNK activation were attenuated when cells were pretreated with forskolin for 30 or 60 minutes but not at 0, 120, or 240 minutes before TNF-α treatment ( Figure 3 ), indicating th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20357815
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"Pretreatment with TAT-SNAP-23 inhibited the increase in plasma membrane expression of gp91 phox in TNF-alpha-primed neutrophils, whereas TNF-alpha activation of ERK1/2 and p38 MAPK was not affected."
21642540
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"These activation kinetics suggest a mechanism of p42/44 action more complicated than a direct phosphorylation of IRS-1 triggered by the early spike of TNFalpha induced p42/44 activity."
11043572
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"Thus, FAN and/or N-SMase do not seem to play an essential role in TNF induced activation of ERK1/2."
10810929
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"However, when curcumin was combined with blue light united red light irradiation, TNF-α-induced activation of ERK was significantly attenuated."
26382065
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"In human adipocytes, pharmacological inhibition of Tpl2 also inhibited ERK1/2 activation induced by IL-1beta and TNF-alpha, whereas insulin effect was not significantly modified (XREF_FIG C)."
19808894
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"Pegylated liposomal-paclitaxel induces ovarian cancer cell apoptosis via TNF induced ERK and AKT signaling pathway."
29620264
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"Our findings show that β-NF inhibits TNF-α-induced NF-kB and ERK1/2 activation and ROS generation, thereby suppressing the expression of adhesion molecules."
26453957
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"Similar mechanisms are found in glioblastoma, where EGFR inhibition induces secretion of tumor necrosis factor alpha (TNFα), which subsequently activates JNK, ERK, and AXL RTK [77]."
32046099
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"ERK pathway is actually activated in RA synovial tissue and cultured RA-FLS, and TNF-alpha can activate the ERK pathway in RA-FLS (Fujisawa et al., 1996)."
21679760
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"Blockade of TNF significantly reduced activation of both p38MAPKalpha and ERK in the synovial membrane, indicating that the intracellular effects of TNF can be inhibited."
16207331
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"Over-expression of UCH-L1 suppresses TNFalpha induced ERK activation in VSMCs."
19945429
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"This suggests that ENS activation limits TNF-alpha production by inhibition of LPS induced ERK activation and decrease of AMPK activity."
25497784
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"Inhibition of IL1 reduced the activation of p38-MAPK and blockade of TNF reduced the activation of ERK and p38-MAPK XREF_BIBR."
27321128
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"The C1q and tumor necrosis factor related protein 3 [C1QTNF3; also known as (a. k. a.) CTRP3] is known to stimulate ERK1/2 and p38 MAPK [58] ."
22530940
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"U0126, an inhibitor of MEK1/2, inhibited the TNF-alpha-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and the metastatic properties in vitro without affecting cell proliferation."
16253760
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"However, the addition of TNF-alpha and IL-1beta causes strong p38 and ERK1/2 signaling activation, which has a role in downregulation of Runx2 expression and activation."
24743742
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"Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40."
12881420
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"Kinases in this complex were reported to be activated by TNFalpha treatment of cells or in vitro by the addition of either ubiquitin and ubiquitin conjugating enzymes or the mitogen activated protein [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9630230
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"Our data showed that Erk phsphorylation was significantly stimulated by TNF-alpha at a dose of 1 ng/ml rather than those of p38 and Akt."
21545687
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"This study examined whether Paeoniae Radix rubra extract (PRRE) and Paeoniflorin (PF) affect mucin production, gene expression including MUC5AC, and protein expression related to the ERK pathway induced by TNF-α from human airway epithelial cells."
36436716
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"Macrophages from Tpl2 knockout mice are defective in ERK1/2 activation induced by TNF, while activation of other MAPKs and NFκB remain unaffected ( xref )."
22017429
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"Interestingly, the NF-kappaB inhibitor emodin also has significant inhibitory effects on TNF induced ERK activation which may due to the fact that it is a broad spectrum anti-inflammatory agent."
17292586
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"RNAi studies showed that MLK3 can promote microtubule instability, is required for cell proliferation in epithelial and fibroblast cells, and is required for TNF and EGF activation of extracellular signal regulated kinase (ERK) and JNK [XREF_BIBR, XREF_BIBR]."
19782705
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"TNF suppresses CD4 + T-CELL responses by attenuating calcium and NFAT dependent but not ERK dependent signal transduction pathways."
| PMC
bel
"Omega-6 phospholipids, e.g. dilinoleoylphosphatidylcholine (DLPC), have been shown to block TNF-α and H 2 O 2 activation of MAPK as well as blocks IκBα phosphorylation in the SH-SY5Y cells and prevents the phosphorylation and activation of NF-κB."
27288790
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"We and others, have established that TNF activates NF-kB, c-Jun, ERK, p38 MAP kinase, and Akt pathways in bone cells [18-21]."
12946103
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"Our in vivo studies also indicated that TNF-alpha causes an ERK1/2 dependent activation of Elk-1 and that Elk-1 activation was required for the TNF-alpha-induced increase in intestinal MLCK expression[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24121020
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"PTPN2 in turn regulates TNF induced ERK- and p38-MAPK activity as well as IL-6 and IL-8 secretion."
25581833
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"These results suggest that the activation of ERK, p38, and JNK is involved in TNF-α-induced ICAM-1 expression, and the combination of rapamycin (80 nM) and MPA (20 nM) modulates signaling cascades that involve TNF-α-induced activation of ERK and p38 but not JNK ( xref )."
25673929
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"We therefore examined whether Sam68 mediates TNF-induced JNK and ERK activation."
21620750
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"We found that overexpression of the GM3 synthase gene inhibited DNA synthesis and ERK1/2 activity induced by TNF-alpha in VSMC, whereas the basal levels of DNA synthesis and ERK1/2 activity remained unchanged."
21072492
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"Minocycline impairs TNF-α-induced activation of MAP kinases p38, JNK and ERK1/2."
31266502
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"P. gingivalis Impairs TNFα-Dependent Activation of ERK and NFκB."
27698456
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"Interestingly, while the activation of p38 MAPK by IL-1β, fibroblast growth factor 1 (FGF-1), or FGF-2 was sensitive to dexamethasone or fluticasone propionate ( xref ; xref ; xref ), the activation of ERK1/2 MAPK by TNF was found to be insensitive to GCs ( xref ; xref )."
32473159
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"It has been reported that HCV core protein [27], proinflammatory cytokine TNF-alpha [28], and reactive oxygen species (ROS) [29] could activate ERK signaling and CREB transcriptional activity, which m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22613004
reach
"Since AKT, NF-kappaB, or ERK1/2 signaling pathways were activated in HCT116 cells by IL-17 and/or TNF-alpha, we tested if inhibitors of AKT (AZD5363), NF-kappaB (Bay11-7082), or ERK1/2 (U0126) signaling pathways could diminish PD-L1 protein expression induced by IL-17 and/or TNF-alpha."
28223102
sparser
"TNF-α activates p38, TACE, and ERK through GEF-H1."
23389627
reach
"These data indicate that TNF preferentially activates p38MAPKalpha and ERK in synovial membrane exposed to TNF."
16207331
reach
"XREF_BIBR TNF-alpha can strongly activate JNK and ERK, followed by the phosphorylation of Bcl-2."
28721018
reach
"The extracellular signal regulated kinase (ERK) and nuclear factor-kappa B (NF-kappaB) pathways were activated by TNF-alpha in leiomyoma SMCs."
25398968
sparser
"In brown adipocytes, TNF-α could activate MAPK and ERK, which led to the serine phosphorylation of IRS-2 and then caused IR ( xref )."
33013697
reach
"The binding of the identified complexes to DNA was inhibited by pretreatment with U0126 but not with U0124, indicating DNA binding of Egr-1 is dependent on TNFalpha activated MEK and ERK signalling."
19144181
sparser
"Williams et al. demonstrated that TNF-α-induced ERK activation and cytokine production are mediated by the Rac1 pathway in HeLa cells xref ."
25121739
sparser
"To determine whether there is a cross-talk between these two pathways, the effect of pharmacological inhibition of IKKβ on IL-1β and TNF-α–induced MEK and ERK1/2 activation was determined."
19808894
reach
"Interestingly, over-expression of UCH-L1 attenuated TNFalpha induced activation of ERK in RASMCs (XREF_FIG), suggesting that suppression of ERK activation also contributes to the growth inhibitory effect of UCH-L1 in TNFalpha inflamed VSMCs."
19945429
sparser
"We found that TNF activated ERK1/2 in a time-dependent manner ( xref ) and was sustained up to 10 hrs following TNF treatment."
18266953
reach
"The authors previously revealed that sanguinarine inhibited osteoclast formation and bone resorption by suppressing the tumor necrosis factor ligand superfamily member 11 induced nuclear factor-kappaB and extracellular signal regulated kinase signaling pathways."
28498448
reach
"This blockage of osteoclastogenesis elicited by ACCX results from abrogation of the NF-kappaB and ERK pathways induced by either RANKL or TNFalpha, respectively."
17656322
sparser
"However, rapa-ECs displayed heightened basal and TNF-induced activation of ERK1/2 ( xref )."
24516119
sparser
"On the other hand, TRAF6 deficiency did not affect the TNFalpha-induced activation of mitogen-activated protein (MAP) kinases, ERK, JNK, and p38."
19091594
reach
"Among the kinases under investigation, ERK 1/2 p44 is the pathway activated only by TNF-alpha 22."
28661042
reach
"NQO2 is also required for TNF induced activation of ERK1/2 in keratinocytes XREF_BIBR."
23554738
sparser
"Furthermore, we found that 50 μM of U0126, an ERK inhibitor, can totally block the ERK1/2 phosphorylation (Data not show), indicating that U0126 (50 μM) can block the TNF-α-induced ERK activation in C2C12 cells."
29435145
reach
"Although none of the treatments affected ERK phosphorylation after 1 hour (data not shown), by 6 hours both TVX and TVX and TNF treatments led to an increase in ERK activation compared to cells treated with vehicles or TNF (XREF_FIG)."
25748550
sparser
"As described herein, TNF-α activates PKCδ, ERK1/2, and JNK2 in RA synovial fibroblasts."
20131228
reach
"Recently, for the first time, it was reported that sanguinarine inhibits osteoclast differentiation and bone resorption by suppressing the tumor necrosis factor ligand superfamily member 11 induced nuclear factor-kappaB and extracellular signal regulated kinase signaling pathways in vitro."
28498448
reach
"Furthermore, it was reported that the secreted TNF-alpha activates ERK1/2 pathways by an autocrine loop in activated microglia [38]."
30071304
reach
"Western blot assay testified that depletion of ATM by inhibitor or gene silencing decreased TNF-alpha induced the activation of ERK, p38 and p65."
27556690
sparser
"In this work, we demonstrate that in the premalignant keratinocyte cell line HaCaT, TNF-alpha activates Akt, ERK1/2 and p38."
18557926
reach
"In intestinal epithelial cell line Caco-2, ERK1/2 activation induced by TNF-alpha leads to a significant enhancement in paracellular permeability [20], whereas IL-1beta increases paracellular permeabi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26148935
reach
"TNF-alpha was also shown to stimulate ERK activity in synovial tissue in vivo in the TNF-alpha-transgenic mouse, an effect inhibited by blockade of TNF-alpha."
20131228
reach
"Interestingly, the enzymatic function of caspase-8 is not required for TNF induced ERK activation."
16129431
reach
"ERK, JNK, and p38 are expressed and activated in the synovial tissue of RA patients, and IL-1beta and TNF-alpha induce ERK, p38, and JNK activation in RA FLS [XREF_BIBR]."
26339143
sparser
"Interestingly, the enzymatic function of caspase-8 is not required for TNF-induced ERK activation."
16129431
reach
"On the other hand, butyrate also prevents inflammation by increasing the production of IL-10 [68], thus preventing the activation of ERK1/2 mediated by TNF-α [43]."
34201776
reach
"Our results indicate that the ERK cascade is activated in HSC by TNF-alpha and TGF-beta, but that this activation is not related to the anti- and pro fibrogenic effects exerted by each cytokine respec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12297293
sparser
"Considering that the p44 and p42 extracellular signal-related kinases (ERK 1 and 2) can be activated by TNF in BAE cells and that their activation is associated with inhibition of apoptosis in some c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12639717
sparser
"It was identified that TNF-α activates ERK 1/2, which resulted in an increase of phosphorylated protein content in cells."
| PMC
sparser
"To further support our hypothesis, we generated alanine and phosphomimetic (aspartic acid) mutants of TNFR1 at positions T411 and T417, ectopically expressed these mutants, and determined their influence on TNF-α-induced activations of ERKs, AKT, STAT3, p38α, and JNK1/2."
32159413
reach
"Compared with the effect of Dex alone, the phosphorylation levels of p38 MAPK, ERK1/2 and JNK induced by TNF-α decreased by 33, 75, and 63%, respectively, after R406 pretreatment.Next, we used inhibitors of MAPKs in BEAS-2B cells to study the effects of MAPK phosphorylation on GR-Ser226."
35600871
reach
"However, the mechanism of TNF-alpha mediated activation of extracellular signal regulated kinase (ERK)/M1AP kinase has not been established clearly."
11221891
sparser
"Subsequently, TNFalpha activated ERK, JNK and p38 in apoptosis and autophagy, in which ERK/JNK played a promoting role whereas p38 played an inhibiting one."
18796294
reach
"Activation of ERK by TNF was intact but enhanced in Sam68 knockout cells (XREF_FIG)."
21620750
sparser
"We also note that both Ang-1 and Ang-2 slightly enhance TNF-dependent ERK and p38 activation."
24404127
sparser
"We show here that glucocorticoids and RA inhibit JNK activation by tumor necrosis factor-α (TNFα) and also reduce ERK activation by TNFα or VEGF in several endothelial cell lines."
10518034
reach
"A maximal concentration of 50 ng/ml TNF induced a 3.5 +/- 0.6, 4.2 +/- 0.2 and 3.1 +/- 0.6 fold increase in ERK, p38MAPK and JNK activities respectively, compared to non activated (total MAPK immunore[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17292586
reach
"IL-1beta and TNF-alpha can induce extracellular signal regulated kinase (ERK), IKK, IkappaB degradation and NF-kappaB activation."
12934647
sparser
"We found that extracellular signal-regulated kinases 1 and 2 (ERK1/2) in KS cells were significantly activated by TNF-alpha through tyrosine/threonine phosphorylation."
10092829
reach
"TNF-alpha and IL6 appear to create a positive feedback loop during cancer development, and also activate ERK / MAPK cascades known to regulate cell proliferation, migration and angiogenesis 31."
23687623
sparser
"Whereas TNFα activated Akt, ERK and P38 MAPK simultaneously in hMEC, inhibitors of Akt and P38 MAPK, but not ERK blunted TNFα-induced TSP-1 expression."
25963668
sparser
"To shed light on this issue, we considered that SH3-binding sequence PPAP at the far C-terminal of the TNFR1 could play a role in TNFα-induced activations of ERK1/2 and AKT, whose activations require Grb2-Ras-Raf pathway."
33907493
reach
"AR was necessary for TNF-alpha activation of ERK1/2 and Akt signaling in hepatocytes."
23108309
reach
"These results suggest that TNF-alpha promotes the survival of osteoclasts by engaging the phosphatidylinositol 3-kinase Akt and MEK and ERK signaling pathways."
11675379
reach
"On the other hand, TNF clearly activated IkappaB (and gradually Akt and Erk) in preadipocytes whereas it had no or less effect in adipocytes (XREF_FIG)."
24719782
reach
"TNF and Ras can activate a significant number of the above noted pathways (p38, ERK, and NF-kappaB in particular) in generating cells with CD44 +/CD24- phenotype."
20691079
sparser
"Although IL-10 did not alter activation of ERK by GM-CSF or TNF-alpha, it did inhibit activation induced by LPS."
16106368
sparser
"TNF, IL-1, IL-6 and IL-17 activate all three MAPK families (JNK, p38 MAP kinase, and extracellular regulating kinase (ERK)) in synovial fibroblasts [ xref - xref ], and TNF and IL-1 also activate ERK, JNK and p38 MAPK in chondrocytes [ xref ]."
23028407
reach
"Egr-1 may therefore regulate a select number of genes in response to TNFalpha activated MEK and ERK signalling."
19144181
reach
"On the other hand, TNFalpha does not activate PI3-kinase, but strongly activates ERK, p38 MAPK, and JNK [27,28]."
12437985
reach
"These data indicated that sesamin could slightly reduce the activation of p38 and p44/42 ERK induced by TNF-alpha in hSF cells and shift to activation of the SAPK and JNK signalling pathway."
29237438
reach
"In rat Kupffer cells maximal TNFalpha expression is dependent on activation of ERK1/2 and Egr-1 [45]."
19157621
reach
"Then, we found that TNF-alpha, IL-1beta, and BMP-2 alone all could activate p38, ERK1/2, and JNK1/2 signaling, respectively."
24743742
reach
"In addition, activation of kinases, including ERK 1/2, JNK and p38 MAPK are among the early downstream effects of TNF-alpha (Barbin et al., 2001; Eder, 1997) and TNF-alpha activates ERK 1/2 in E2 resp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21784129
eidos
"They observed that while TNF-alpha transiently activated ERK ( less than half an hour ) , more time was needed for the disturbing effects of TNF-alpha on insulin signaling to develop ( 2.5-4 h ) ( Engelman et al ., 2000 [ 11 ] ) ."
30233281
sparser
"These findings suggest that TNF-alpha-induced ERK activation negatively controls maturation and IL-12 production in murine DC."
11781388
reach
"TNFalpha, angiotensin II, and free fatty acid produced from perivas- cular adipose tissue activate Akt pathway, but not ERK1/2 pathway."
24627704
reach
"To examine the TNF-alpha regulated activation of the NF-kappaB, ERK or JNK signaling pathways, western blot analysis was used to detect protein phosphorylation in each pathway."
27221006
reach
"TNF-alpha significantly increased intracellular ROS generation and then ERK activation, which was blocked by notoginsenoside R1 or DPI and apocynin, inhibitors of NADPH oxidase, or the antioxidant NAC."
16632126
sparser
"Inhibition of Rac1 does not modulate TNF-alpha-induced ERK1/2 and Akt activation."
16798728
sparser
"Several lines of evidence indicated that the JNK, ERK1/2 and p38 MAPKs could be activated by TNF-α via a TRAF2- and TGF-β–associated kinase 1 (TAK1)-dependent process [ xref – xref ]."
31266502
reach
"Notably, by gene silencing or kinase inhibition, we proposed for the first time that ATM is a key up-stream regulator of TNF-alpha activated ERK and p38-NF-kappaB pathway."
27556690
reach
"The MAP kinases p38, ERK, and JNK were transiently activated by TNF-alpha (n = 3; Fig. 4)."
24021283
reach
"In this study, JNK and p38MAPK pathways, but not ERK1/2, were activated by TNFalpha, and subsequently regulated by butyrate and propionate."
33671042
reach
"Unlike in BEAS-2B cells, TNFα enhanced RBD-induced ERK1/2 activation in ECs (Fig. S4c-e)."
34741187
reach
"Levels of several mitogen activated protein kinase proteins, namely p38, c-Jun N-terminal kinase (JNK) and extracellular signal regulated kinase (ERK), were detected in cells treated with TNF-alpha using western blot analysis."
29467899
reach
"Furthermore, we provide evidence that the TNF dependent activation of ERK and cPLA (2) requires the intact death domain of TNF-R55."
10913368
reach
"As the possible mechanisms, gamma2pf activated ERK and p38 MAPK but inactivated Akt in HUVECs."
24238220
reach
"Because TNF-alpha is known to activate ERK1/2, p38 MAPK, JNK, and NF-kappaB signaling pathways, we examined their involvement in the activation of p35 promoter activity."
19049962
reach
"To verify if TNFalpha induced ERK activation might relate to myostatin, C2C12 myoblasts were stably transfected with a vector coding for the endogenous myostatin inhibitor follistatin."
21048967
reach
"TNFalpha activated the ERK-1/2, p38 MAPK, PI-3-kinase and NF-kappaB pathways but not the JNK pathway, as determined by immunoblotting with phospho specific antibodies."
17560598
reach
"LPS/TLR4 and TNFa/TNFR1 promote activity of PI3K/AKT, Ras/ERK, p38, and JNK kinases, whereas p38 and JNK can also become activated by Rac1 or RhoA."
35634305
sparser
"Activation of ERK1/2, P38 and JNK MAPKs by TNF-α Mediates RANKL Expression."
31921183
sparser
"However, this may at least in part be due to a block of NTF-induced ERK activation."
12595244
reach
"P. gingivalis Impairs TNFalpha Dependent Activation of ERK and NFkappaB."
27698456
reach
"Although our results are similar to those of studies in human knee chondrocytes where TNF-alpha induced ERK, p38, and JNK activation, no correlation with their target genes (such as MMP-13) was establ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12878172
sparser
"Dex inhibited (2–3-fold) ERK activation by TNFα or VEGF in HMEC-1 cells ( )."
10518034
reach
"However, this " canonical TNF-alpha signaling " does not explain how ERK, AKT, and STAT3 can be activated by TNF-alpha."
32159413
reach
"The main activator of the TNF induced ERK1/2 cascade is TPL-2."
22017429
reach
"e ERK1/2 were activated by CO2 independently of upstream MEK1/2 in ECs, as MEK1/2 inhibitors (2.5 µM U0126 and 25 µM PD98059) did not abolish the CO2-induced ERK1/2 activation but did prevent ERK1/2 activation by 10 ng/ml TNFα."
34741187
reach
"TNFα increases sEPSC frequency via activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) in presynaptic terminals, possibly through activation of adenylyl cyclase, protein kinase (PKA), or extracellular signal-related kinase (ERK) [60]."
24024042
sparser
"Pretreatment with TAT–SNAP-23 inhibited the increase in plasma membrane expression of gp91 phox in TNF-α–primed neutrophils, whereas TNF-α activation of ERK1/2 and p38 MAPK was not affected."
21642540
reach
"TNF-alpha induces the activation of extracellular signal regulated kinase (ERK) 1/2, JNK (c-jun N-terminal kinase), AMPK, and PKA (cyclic AMP dependent protein kinase), which are involved in the mechanism of TNF-alpha-induced lipolysis."
26732322
reach
"TNF-alpha increased activation of ERK1/2 and JNK, previously implicated in phosphorylation of Ser (82) of PPARgamma1 and resultant negative regulation of PPARgamma transactivity."
14656714
reach
"Here, we asked if TNF-alpha activation of ERK signalling also leads to increased transcription of the TGF-beta 1 gene."
20141610
reach
"TNF is a potent activator of MAPK signaling; however, the mechanisms whereby TNF-alpha activates the ERK MAPK pathway, remain poorly understood [XREF_BIBR, XREF_BIBR]."
22988345
reach
"In these studies, TNF-alpha was shown to induce NF-kappaB, Akt, ERK and p38 MAPK and activated Akt and inhibited GSK-3beta activity which resulted in elevated Snail activity [XREF_BIBR]."
27999207
sparser
"Time-course studies indicated that TNF-α–induced ERK1/2 activation (, B and C) preceded Elk-1 activation."
24121020
reach
"Otherwise, TNFalpha treatment induces the activation of the MAPK and ERK pathway that depends on the specific regulation of FLIP-L transcription by NF-kappaB."
23412386
reach
"Furthermore, TNF-alpha induces activation of the ERK pathway in human RA synovial fibroblast."
20131228
reach
"C1q/TNF-related protein 9 (CTRP9) may contribute to VSMC phenotypic switching by mediating ERK signaling."
32630640
reach
"We studied both apathogenic (Tula and Topografov) and pathogenic (Puumala and Seoul) hantaviruses for their ability to regulate cellular signaling pathways and observed a direct virus mediated down-regulation of external signal regulated kinases 1 and 2 (ERK1/2) survival pathway activity, which was dramatically enhanced by TNF-alpha."
18822184
reach
"Although some information is known about selected changes in chondrocyte gene expression in response to TNFalpha activated MEK and ERK signalling, the overall impact of this pathway on changes to the chondrocyte gene expression and the downstream transcriptional mechanisms mediating these changes has been poorly defined."
19144181
reach
"In myeloma tumour cells, MAP3K8 acts as mitogen induced MAP3K in mitosis and is required for TNFalpha mediated ERK activation."
23252623
reach
"In conclusion, TNFalpha mediated ERK, AKT, JNK, p38 activations are affected by TNFR1 SH3 domain modifications."
33907493
sparser
"In vivo , overexpression of TNF induced activation of p38MAPKα and ERK in the synovial membrane, whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis."
16207331
reach
"To examine the role that ERK signaling plays in promoting cell death, HepG2 cells were treated with TVX and/or TNF in the presence and absence of U0126."
25748550
reach
"Our results showed that TNF-alpha induced the rapid and strong activation of ERK and JNK, as the phosphorylated forms of these two MAPK were detected and peaked at 15 minutes and then returned to thei[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20357815
reach
"It was reported that TNF-alpha may promote breast cancer cell migration by inducing activation of the MAPK and ERK signaling pathway [XREF_BIBR]."
27464624
reach
"Both TNF-alpha and IL-1beta signaling requires FAK and Pyk2 activity to activate ERK and JNK MAPKs leading to inflammatory gene expression."
31110200
sparser
"e ERK1/2 were activated by CO2 independently of upstream MEK1/2 in ECs, as MEK1/2 inhibitors (2.5 µM U0126 and 25 µM PD98059) did not abolish the CO2-induced ERK1/2 activation but did prevent ERK1/2 activation by 10 ng/ml TNFα."
34741187
sparser
"These data indicate that TNF preferentially activates p38MAPKα and ERK in synovial membrane exposed to TNF."
16207331
reach
"According these reports, we suggest that TNF-α induced ERK/NF-kb and EGFR."
23651618
reach
"This is in agreement with our earlier finding that TNFalpha triggered ERK1/2 and NFkappaB activities and proinflammatory cytokine and chemokine production are downstream of PLD1 activation XREF_BIBR."
20463923
reach
"The results of three independent experiments are presented PD98059), while activation of ERK1/2 by TNFα was abolished under these conditions (Fig. 1e )."
34741187
reach
"To examine the responsiveness of IKK, JNK, p38, and ERK to stimulation at and during S-phase progression, cells were treated with TNFalpha for 10 min at different times after release from aphidicolin."
16723255
reach
"The suppression of TNF-α by HP-PRRSV was mediated through inhibiting the ERK signaling pathway, and nsp1β and nsp11 were responsible for the inhibitory effect on TNF-α production induced by HP-PRRSV and the differential TNF-α production in PAMs (He et al., 2015; Hou et al., 2012a)."
32311386
sparser
"In addition, activation of kinases, including ERK 1/2, JNK and p38 MAPK are among the early downstream effects of TNF-α ( Barbin et al., 2001; Eder, 1997 ) and TNF-α activates ERK 1/2 in E2-responsive[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21784129
reach
"Tumor Necrosis Factor Receptor associated Factor 6 (TRAF6) Stimulates Extracellular Signal regulated Kinase (ERK) Activity in CD40 Signaling Along a Ras independent Pathway."
9432981
reach
"In keeping with our previous findings that TNFalpha induced ERK1/2 activation requires Endo-PDI as well as PDI, siRNA against either of the two prevented the TNFalpha mediated induction of MMP-9 and c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24103565
sparser
"In human neutrophils, TNF activated both p38 MAPK and ERK1/2 principally via TNFR-1."
17138860
reach
"These data indicate that the observed increase in TNF production from human skin mast cells pre-treated with 10 muM Resveratrol was not due to an increase in FcepsilonRI induced activation of Akt, p38[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26777630
reach
"The TAK1 inhibitor (5z)-7-oxozeaenol (5ZO) inhibited both the primary activation of NFκB, JNK, p38, and MEK/ERK signaling induced by TNFα and IL-1α (Fig. S11A) and blocked the increased signaling conferred by p38 inhibition (Fig. S11B)."
29511118
eidos
"Tumor necrosis factor can also increase ERK and other molecules to reduce edema , and aquaporin also plays an important role in the occurrence of edema ( Mamtilahun et al ., 2019 ) ."
34122124
reach
"It has been shown that the ligation of TNF-alpha with TNF receptor initiates the activations of ERK-1/2, JNK, and p38-kinase in several cells and cell lines, including monocyte derived DCs [29,30]."
15454113
reach
"AC also prevented, in vitro, tumor necrosis factor alpha induced Caco-2 monolayer permeabilization, NOX1/4 upregulation, oxidative stress, and NF-kappaB and ERK activation."
31330482
reach
"Vitamin D significantly reduced palmitate induced TNF-alpha and IL-6 secretion as well as palmitate stimulated activation of JNK and ERK1/2."
30076857
reach
"TNF stimulated MMP9 production also activates NF-kappaB and ERK signaling pathways XREF_BIBR."
24824968
sparser
"Collectively, these data suggest that monocytes/macrophages in liver metastases induced tumor cell proliferation, migration and invasion, and upregulated S100a8 and S100a9 expression through TNFα-induced ERK activation."
27086923
reach
"In addition, spinal administration of LV-shIL-33 reduced the overexpression of spinal IL-1beta, TNF-alpha, and COX-2 and attenuated the activation of C-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and NF-kappaB/p65 but not p38."
29329586
reach
"EGF and TNFalpha ligands stimulate ERK, JNK and p38 MAPK cascades, the PI3K and AKT pathways, and the NFkappaB cascade."
24321545
reach
"Regulation of TNF mediated antiapoptotic signaling in human neutrophils : role of delta-PKC and ERK1/2."
17138860
reach
"We also found that tumor necrosis factor receptor (TNFR) 2 was involved in CD73 induced AKT and ERK signaling pathway activation in PDAC."
30927045
reach
"It has been postulated that these inhibitors suppress NF-kb and TNF-alpha induces JNK, MAPK, and ERK activation via the AKT pathway, thus downregulating genes for inflammation and proliferation [XREF_BIBR]."
33602138
reach
"This result indicates that TNFalpha mediated activation of ERK1/2 is dependent on NF-kappaB activation."
23412386
reach
"Finally, we showed that TNFalpha time-dependently activated NF-kappaB, AKT, ERK, p38 MAPK signaling pathways, and elevated Snail stability by activating AKT pathway that subsequently inhibited GSK-3beta activity."
23769744
reach
"Selective regulation of tumor necrosis factor induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase."
15696169
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"In this regard, ERK1/2 activation is induced by C5a in neutrophils, and by TNFalpha or LPS in primary monocytes XREF_BIBR, XREF_BIBR."
33139717
reach
"TNF receptors can activate ERK1/2 by several mechanisms, including neutral sphingomyelinase dependent activation of Raf [XREF_BIBR], and direct interaction with the Grb2 and SOS exchange factors which activate Ras [XREF_BIBR]."
20815659
sparser
"Dominant negative Ras, but not Rap, blocks NTF-induced ERK activation and VR1 upregulation."
12595244
reach
"Using human primary astrocytes, we found that TNF-stimulation activated ERK, JNK and p38, of which ERK activation was the strongest."
24086560
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"TNF-alpha activates p38, TACE, and ERK through GEF-H1."
23389627
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"As shown in the representative blot in XREF_FIG and the densitometric analysis of 3 separate blots from 3 different experiments shown in XREF_FIG, TNFalpha induced the activation of ERK 1/2 with a time course of increasing activation out to at least 5 h. Immunoblotting to quantify total ERK 1/2 showed that there was no change in the amount of total ERK 1/2 protein during the incubation period."
27073025
reach
"We recently reported that TNF-alpha activates the extracellular regulated kinase (ERK)-specific pathway in fibroblasts resulting in stabilization of TGF-beta 1 mRNA and increased expression of TGF-beta 1."
20141610
reach
"We recently showed that TNF-alpha rapidly activates the ERK signaling pathway resulting in stabilization of TGF-beta 1 mRNA [XREF_BIBR]."
20141610
reach
"Leptin caused maximal PI3K-C2alpha activation after 20 min, which correlates well with previously reported data on leptin signalling in J774.2 macrophages, where activation of ObRb, JAK-2, STAT3, and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12788079
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"Although TNF-alpha stimulated and activated ERK under otherwise basal conditions, it had no effect on ERK when cells were transfected with EPCR siRNA."
24495480
reach
"In agreement with these reports, we found that LPS and TNFalpha activated Erk1/2, NFkB, IkBalpha pathways, whereas IL6 induced only activation of Erk1/2 signalling in our HSMM model."
24521217
sparser
"The idea that TNF-induced activation of ERK and/or cPLA 2 is coupled to the DD of TNFR1 is in agreement with recent observations from other investigators: (i) Boone et al. showed by analyzing TNFR1 m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12401196
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"In lung epithelial cells, alpha-tocoherol blocks TNFalpha activation of NFkB, MAPK, and ERK [XREF_BIBR]."
20923401
reach
"XREF_BIBR TNF-alpha and other inflammatory cytokines activate JNK and ERK."
28721018
sparser
"Furthermore, when cells were incubated for 5 minutes with dexamethasone and TNF-α, Western blots showed an inhibiting effect of dexamethasone on TNF-α-induced ERK activation (188±16% of control after TNF-α alone versus 125±5% of control after dexamethasone and TNF-α treatment, n = 4, * P <0.05 compared to TNF-α alone, xref )."
23152905
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"Recent studies showed that β2-receptor agonists attenuated the release of TNF-α and MCP-1 induced by LPS from a mouse macrophage cell line by mediating the cAMP-dependent inhibition of ERK and p38MAPK pathways (Keranen et al., 2016, 2017)."
30559673
sparser
"Indeed, published studies indicate that TNF activates ERK [ xref ] in fibroblast-like synoviocytes and Akt in normal human FS-4 dermal fibroblasts [ xref ]."
26198031
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"In our study, F. alocis challenge did not affect TNFalpha induced ERK1/2 activation, and when apoptosis was tested, the pro survival effect of the cytokine was not impaired."
32373107
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"IL-1beta and TNFalpha activated the ERKs in neonatal myocytes."
9762348
reach
"The ROS induced CO-mediated survival mechanism requires functional interactions between the protein kinase B/Akt and extracellular signal related kinase (ERK)/p38 MAPK signaling pathways activated by TNF-alpha."
21123734
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"In addition, NIBP knockdown inhibited the TNF-alpha mediated activation of the canonical NF-kappaB and ERK and JNK pathways."
28125661
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"The aims of this study were to investigate whether fibronectin (FN) or the inflammatory cytokines interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha) activate JNK, ERK, and AP-1 activity in HSC and induce the gene expression of the matrix metalloproteinase transin."
9357821
eidos
"By binding to the TNF receptor on the osteocyte surface , TNF-alpha activates the ERK1 / 2 , P38 and Jun kinase ( JNK ) MAPK signaling pathways and / or the transcription factor nuclear factor-kappa B ( NF-kappaB ) , which enhances RANKL expression in osteocytes and consequently promotes alveolar bone resorption [ 34 , 35 ] ( Fig. 2 ) ."
33308247
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"Indeed, IL-1beta, TNFalpha, and IFNgamma promote activation of PKCdelta, IKK, JNK, p38 MAPK, and ERK, which phosphorylate IRS proteins at " inhibitory " Ser sites."
20547979
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"IL-1 beta and TNF-alpha activated extracellular signal regulated kinase 1/2, c-Jun N-terminal kinase and stress activated protein kinase, and p38 mitogen activated protein kinase."
12131776
reach
"For example, MAP3K8 (also called Tpl2), an upstream kinase to ERK, is up-regulated in obese adipocytes and mediates TNFalpha induced ERK activation and lipolysis XREF_BIBR."
23951179
trips
"By using the EGF receptor (EGFR) tyrosine kinase inhibitor, AG1487 and the Src family inhibitor, PP-1, we established that TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes."
18080320
sparser
"L929 cells overexpressing hPEBP4 are resistant to both TNFalpha-induced ERK1/2, MEK1, and JNK activation and TNFalpha-mediated apoptosis."
15302887
reach
"TNFalpha initiates the activation of ERK and mitogen activated protein kinase through the adaptor protein, Grb2, binding to the TNFalpha receptor 1, leading to activation of the ras and mitogen activated kinase kinase (MEK)/ERK signalling cascade [XREF_BIBR]."
19144181
reach
"Knockdown of TRIF using TRIF siRNA suppressed BIC, miR-155, IL-6, and TNF-alpha expression and inhibited the ERK 1/2 and SOCS1-STAT3-NF-kappaB signaling pathways."
29977930
reach
"The percentage of cells in G2/M was not affected by any treatment in the absence or presence of U0126.To examine the role that ERK signaling plays in promoting cell death, HepG2 cells were treated wit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25748550
reach
"Inhibition of IL-1beta but not TNF-alpha in CoMTB decreases p38, Erk, and Jnk activity in astrocytes."
17079649
reach
"The Fas associated death domain protein/caspase-8/c-FLIP signaling pathway is involved in TNF induced activation of ERK."
16129431
reach
"Furthermore, TNF-alpha augmented the activities of NF-kappaB, ERK and JNK, and promoted MSC adhesion to HUVECs, while the signaling pathway inhibitors exhibited no observable effect on adhesion."
27221006
reach
"In U937 leukemia cells, TNF-alpha activates ERK in a SphK dependent manner : DMS inhibits TNF-alpha-induced activation of ERK and exogenous S1P activates ERK independently of TNF-alpha [56]."
12531554
sparser
"This observation raises the possibility that MMP9 expression can be promoted through TNFα-induced ERK activation when WASF3 levels are repressed."
21544801
sparser
"Considering that the p44 and p42 extracellular signal-related kinases (ERK 1 and 2) can be activated by TNF in BAE cells and that their activation is associated with inhibition of apoptosis in some c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12639717
reach
"Two modes of ERK activation by TNF in keratinocytes : different cellular outcomes and bi-directional modulation by vitamin D."
18080320
reach
"ERK signaling is an important regulator of cancer cell proliferation as well as migration and invasion in many settings, and is activated by TNFalpha (100 ng/mL) in MC38 and LLC cells (XREF_SUPPLEMENTARY), and in several other cancer cell lines."
27086923
sparser
"These results suggest that quercetin may have an anti-proliferative effect on VSMC through the inhibition of TNF-α-induced ERK 1/2 activation."
12589822
reach
"Both TNFalpha and ET-1 activated p38 (MAPK) and extracellular signal regulated kinase (ERK)-1/-2 signalling."
19850966
reach
"In addition, TNF-alpha induced the activation of extracellular-signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinases (JNK), p38 and their down-stream transcription factors nuclear factor kappa B (NF-kappaB) pathway."
32128094
reach
"Previously, Janes et al. showed that TNF-alpha stimulates EGFR transactivation and the ERK signaling pathway in HT-29 cells via an autocrine loop involving TGF-alpha."
22988345
reach
"The effect of TNF-alpha on downstream events included NFkappaB nuclear translocation and increases in DNA binding activities, but did not elicit ERK, JNK, or p38 limb signaling activation."
16216243
sparser
"Thus, TNF-α is capable of activating all three major MAPK pathways, although activation of ERK1/2, p38, or JNK by TNF-α may vary among cell types."
21191629
reach
"IL-1β and TNF-α mainly activate the nuclear factor-κB pathway [32, 33], while IL-6 and IL-10 exert their complex actions through multiple pathways like the Janus kinase 2/signal transducers and activators of transcription 3 pathway and the p38 mitogen-activated protein kinase/extracellular signal-regulated kinase pathway [34, 35]."
29673394
reach
"TNF-alpha failed to induce ERK1/2 activation in the actinomycin D treated cells."
10092829
reach
"In the present study we investigated if the proinflammatory cytokine TNFalpha activates ERK in C2C12 myotube cultures, and whether myostatin is involved in such activation."
21048967
sparser
"Interestingly, our previous study showed that, in synoviocyte cell line MH7A, JH also significantly inhibited TNFα-induced p38 and ERK activation [ xref ]."
30469456
sparser
"In the present study we investigated if the proinflammatory cytokine TNFα activates ERK in C2C12 myotube cultures, and whether myostatin is involved in such activation."
21048967
reach
"TNF-alpha also triggers ERK signaling leading to a downregulation of megalin levels."
27813828
sparser
"As such, the TNFα activation of ERK1/2 likely contributes to the initial, pro-angiogenic phase of AIMP1 and EMAP II signaling."
25535072
reach
"TNF-alpha also activated NF-kappaB, AP-1 and ERK1/2."
16094077
reach
"Exogenous TNFalpha and IFNgamma activates ERK1/2 and increases inflammatory mediator production in cultured lung epithelial cell lines."
20815659
reach
"Mechanistic studies revealed that FVIIa treatment inhibited TNFalpha induced ERK1/2, p38 MAPK, JNK, NF-kB, and C-Jun activation indicating that FVIIa mediated signaling blocks an upstream signaling event in TNFalpha induced signaling cascade."
29669778
sparser
"Also, TNF-induced ERK activation is much stronger in Sam68 knockout cells than the wild type cells."
21620750
sparser
"TNF-α-induced ERK and NF-κB activation was suppressed in FLS with RKIP overexpression."
21556737
reach
"Since AG1478 inhibited the phosphorylation of ERK almost completely and those of p38 and JNK partially, the activation of ERK by TNF-alpha induction was predicted to be exclusively by EGFR transactiva[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29279286
reach
"The activation of ERK1/2 by TNF-α leads to an increase of Egr-1 expression and subsequent elevation of p35 expression (Utreras et al., 2009)."
21253436
reach
"The results suggest that IL-2, IL-4, IFN-gamma, or TNF-alpha may potently enhance BAFF induced aggressive B-cell malignancies.Studies have shown that IL-2, IL-4, IFN-gamma, or TNF-alpha activates Erk1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27235588
reach
"Increased TNF-alpha production, which is significantly more pronounced in neutrophils, may stimulate ERK activation and decrease MCL-1 degradation in these cells and not in monocytes."
29463868
reach
"A role for the kinase activity of RIPK1 in TNF induced ERK activation has been suggested."
25015821
sparser
"The differential effects of ERK regulation on ENaC maybe context-specific, for example EGF mediated ERK activation inhibits ENaC, while TNF dependent ERK activation stimulates amiloride dependent Na transport ( xref )."
33633581
reach
"Second, BMP-2, TNF-alpha, and IL-1beta alone can activate the p38 and ERK1/2 signaling but have an opposing roles in regulating Runx2 expression and activation (XREF_FIG)."
24743742
sparser
"Herein, we report that a posttranscriptional up-regulation of UCH-L1 provides a negative feedback to tumor necrosis factor alpha (TNFalpha)-mediated activation of extracellular signal-regulated kinases (ERK) and proliferation in vascular smooth muscle cells (VSMCs)."
19945429
reach
"Further studies are required to determine whether this endotoxin pathway (TAK1-IKK2-TPL2-MKK1/2-ERK1/2) differs from the signalling pathway that is regulated by TNFalpha to activate ERK."
24647229
reach
"TNFalpha also upregulated ERK1/2 activity and expression of adhesion molecules (ICAM-1, VCAM-1 and E-selectin)."
16806337
sparser
"RNAi studies showed that MLK3 can promote microtubule instability, is required for cell proliferation in epithelial and fibroblast cells, and is required for TNF and EGF activation of extracellular signal-regulated kinase (ERK) and JNK [ xref , xref ]."
19782705
reach
"We have shown, that TNFalpha induces ERK 1/2 dependent migration of VSMC by rapid activation of ERK 1/2 via signaling through the p55 TNFalpha-receptor [8]."
11689211
sparser
"Besides NF-kappa B, celecoxib also suppressed TNF-induced JNK, p38 MAPK, and ERK activation."
15265936
sparser
"Thus, FAN and/or N-SMase do not seem to play an essential role in TNF-induced activation of ERK1/2."
10810929
reach
"In spinal cord outer lamina II neurons, TNF-alpha increases spontaneous EPSC frequency but not amplitude via pre-synaptic transient receptor potential subtype V1 (TRPV1)-mediated glutamate release that is dependent on adenylyl cyclase (AC), PKA, and the extracellular signal regulated kinase (ERK) in pre-synaptic terminals."
24065916
reach
"Hypertonicity enhanced TNF-alpha protein synthesis from LPS- or PMA activated THP-1 cells requires ERK activation and may proceed without TACE."
21256190
sparser
"Extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK) and p38 were rapidly and significantly activated by TNF-alpha in HUVEC."
14720501
reach
"Since TNFalpha was able to activate Akt, ERK and P38 MAPK simultaneously, we next sought to determine which of these pathways are responsible for the regulation of synthesis and secretion of TSP-1 by the hMEC."
25963668
sparser
"As loss of MADD expression also results in reduced Grb2 and Sos1/2 recruitment to TNFR1 and decreased Ras and MEKK1/2 activation ( xref ), this may be the pathway by which TNFα activates ERK in some cell types."
20652490
reach
"As shown in Fig. 2, TNF-alpha stimulated the activation of ERKs, p38, and JNKs, the three subclasses of MAPKs, as early events in the transduction of this signal without affecting their total levels."
12878172
sparser
"Gefitinib completely inhibited TNF- α -induced activation of ERK and JNK at 0.1  μ M ( xref ); however, only a slight inhibition was observed in EGF-induced MAPK activation at the same concentration ( xref )."
15841081
reach
"Moreover, because the cellular phenotype appears to be regulated via the ERK pathway, we focused on determining the mechanisms by which GRK2 regulates the TNFalpha induced ERK pathway."
28572156
reach
"This is the first demonstration that PKCzeta interacts with TLR2 to play an essential role in MTB induced ERK 1/2 activation and subsequent TNF-alpha expression in monocytes and macrophages."
16925784
sparser
"Then, we focused on the involvement of the c-Src and epidermal growth factor receptor (EGFR) as upstream signalling molecules for ERK activation by TNF-α in HS68 cells."
25181017
sparser
"We found that TNF-induced activation of ERK, p38 and JNK is decreased in Rip(-/-) cells."
12776182
reach
"Moreover, we assessed the contribution of NF-kappaB activation to the MAPK and ERK activation induced by TNFalpha stimulation in PC12 cells transfected with the SR-IkappaBalpha plasmid."
23412386
reach
"For example, TNFalpha induced a rapid ERK1/2, p38MAPK, JNK activation in human umbilical vein endothelial cells [XREF_BIBR]."
28170408
reach
"These findings prompted us to determine whether TNF-α overexpression could activate ERK1/2 pathway in TG from TNF-α cTg mice."
26894912
reach
"A specific delta-PKC antagonist, V1.1delta-PKC-Tat peptide, inhibited TNF mediated ERK1/2 activation, but not p38 MAPK."
17138860
reach
"Systemic overexpression of TNF leads to activation of p38MAPKalpha and ERK pathways in the synovial membrane."
16207331
reach
"Taken together, these data suggest that LUBAC mediated linear polyubiquitination is essential for B-cell development and activation, possibly via canonical NF-kappaB and ERK activation induced by the TNF receptor superfamily, but not by the BCR."
23942237
sparser
"TNF-α binds to TNFR1 and activates p38 and ERK1/2, followed by the phosphorylation of cPLA2 on Ser-505."
31302596
sparser
"Rac is required for TNF-α–induced ERK activation."
23389627
reach
"TNF-alpha triggered up to approximately 80% increase (depending on the method used) in CB2 receptor mRNA and/or protein expression in HCASMCs, and induced Ras, p38 MAPK, ERK 1/2, SAPK and JNK and Akt activation, while increasing proliferation and migration."
17994109
reach
"Additionally, by activating TNFR1 in airway smooth muscle, TNF-alpha triggers extracellular signal regulated kinase (ERK) and p38 mitogen activated protein kinases (MAPKs) signaling pathway and transcription factors to turn on a variety of genes (interleukins) that mediate inflammatory and immune responses [XREF_BIBR]."
27445440
reach
"It is noted that TNF-alpha and anti-Fas antibody induced prolonged JNK and ERK, and ROS accumulation were completely inhibited by a caspase inhibitor, suggesting that these events can be downstream of the caspase cascade."
19118041
reach
"In Adv infected hepatocytes, TNF activated antiapoptotic ERK signaling, dependent on autocrine TGF-alpha, but did not significantly activate Akt (XREF_FIG)."
18536058
reach
"In the signaling pathway of MIF (macrophage migration inhibitory factor) regulation of innate immunity, activation of CD74 and ERK1/2 genes induced by TNF-alpha were also altered by the pre-treatment of alpha-tocopherol."
22267916
reach
"Systemic blockade of TNF reduced activation of p38MAPKalpha and ERK, whereas inhibition of IL-1 only affected p38MAPKalpha and blockade of RANK ligand did not result in any decrease in MAPK activation in the synovial membrane."
16207331
sparser
"Interestingly, the NF-κB inhibitor emodin also has significant inhibitory effects on TNF induced ERK activation ( Fig. 2 A, p < 0.01) which may due to the fact that it is a broad spectrum anti-inflam[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17292586
reach
"Second, TNFalpha induces activation of two major survival pathways Akt and ERK, and stress activated p38 MAPK in hMEC simultaneously."
25963668
sparser
"In human trophoblastic cells, TNF-α activates ERK1/2 which in turn initiates NF-κB activation and JNK1/2 which activates AP-1 leading to MMP-9 expression  [35] ."
24361597
sparser
"Inhibitory effects of rapamycin and MPA on TNF-α-induced activation of ERK, p38, and JNK MAPKs in HaCaT cells."
25673929
sparser
"By binding to the TNF receptor on the osteocyte surface, TNF-α activates the ERK1/2, P38 and Jun kinase (JNK) MAPK signaling pathways and/or the transcription factor nuclear factor-kappa B (NF-κB), which enhances RANKL expression in osteocytes and consequently promotes alveolar bone resorption [ xref , xref ] (Fig.  xref )."
33308247
reach
"IL-17-induced CXCL8 expression from colonic epithelial cells in colon cancer not only attracts immunosuppressive neutrophils, but also synergizes with TNF to activate oncogenic epidermal growth factor receptor and ERK signaling pathways."
31727783
reach
"These results indicate that TNF-alpha activates the ERK specific mitogen activated protein kinase pathway leading to increased TGF-beta (1) production in fibroblasts, primarily via a post-transcriptional mechanism that involves stabilization of the TGF-beta (1) transcript."
15653932
reach
"However, PKC inhibitor pretreatment inhibited MEK1/2 and ERK1/2 activation, thus indicating that TNF-alpha may induce Raf-MEK and ERK signaling pathway activation in vascular endothelial cells via PKC dependent pathways (XREF_FIG)."
28091531
sparser
"TNF-alpha or IL-1 alone activated ERK1/2, p38, and JNK maximally at 15 min in HUVEC."
11353829
sparser
"Considering that the p44 and p42 extracellular signal-related kinases (ERK 1 and 2) can be activated by TNF in BAE cells and that their activation is associated with inhibition of apoptosis in some c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12639717
reach
"TNF-alpha activated ERK and increased lipolysis; these effects were inhibited by two specific MEK inhibitors, PD98059 and U0126."
12351429
reach
"TNF-alpha, IL-1beta, and BMP-2 could activate p38, ERK1/2, and JNK1/2 signaling, respectively."
24743742
sparser
"By using the EGF receptor (EGFR) tyrosine kinase inhibitor, AG1487 and the Src family inhibitor, PP-1, we established that TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes."
18080320
reach
"TNF activates ERK and was used as a positive control."
30261438
reach
"Our previous results show that TNF-alpha activation of ERK signalling leads to stabilization of the TGF-beta 1 mRNA in lung fibroblasts [17]."
20141610
sparser
"Our data suggest that TNF-alpha and GM-CSF activate ERKs and p38 MAPK by different signal transduction pathways."
9766635
sparser
"In agreement with these reports, we found that LPS and TNFα activated Erk1/2, NFkB, IkBα pathways, whereas IL6 induced only activation of Erk1/2 signalling in our HSMM model."
24521217
reach
"The aforementioned reports indicate that TNF-alpha is able to activate the JNK and ERK1/2 pathways; however, these pathways might not be involved in the effects of TNF-alpha on hNPCs."
29622770
reach
"p38 and extracellular signal regulated kinase mitogen activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor."
9452444
reach
"We compared the effect of Rac silencing on ERK activation induced by TNF-alpha and plasma membrane depolarization."
23389627
reach
"Our results indicate that TNF-alpha causes activation of ERK1/2, but not p38 kinase, and that targeted inhibition of ERK1/2 kinase activity (but not p38 kinase) prevents the TNF-alpha-induced increase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24121020
reach
"ATM is involved in TNF-alpha inducing ERK and p38-NF-kappaB pathway activation in lung cancer cells."
27556690
sparser
"Of interest, silencing of RhoA using a specific siRNA also reduced TNF-α–induced ERK activation, although to a lesser extent than Rac silencing (Supplemental Figure S2)."
23389627
sparser
"We observed two different patterns of ERK activation by TNF-α, an early phase in the ileum and a late phase in the duodenum."
21427409
reach
"In addition, while Apigenin and Luteolin slightly inhibited TNFalpha induced JNK activation, they had no effect on TNFalpha induced activation of ERK and p38."
21443976
sparser
"Specifically, TNFRI206-211 had no effect on the TNF-induced activation of ERK, JNK, and NF-κB. Likewise, a TNFR domain responsible for connecting TNF-JNK signaling may be identified and characterized, which would help in the design of specific inhibitors of JNK but not p38 or ERK to influence TNF-mediated effects."
33198301
sparser
"Most importantly, the lack of effect of MPTAG on TNF-α-induced ERK and p38 MAPK activation suggested specificity of its action on Akt in these cells."
23071583
reach
"TNFalpha triggered the activation of transcription factors NF-kappaB and AP-1, and MAPKs ERK1/2, JNK, and p38."
22425757
sparser
"The major findings of the present study were as follows: (1) TNF-α induced DNA synthesis and ERK1/2 activation on HASMC were inhibited by quercetin in a concentration-dependent manner (10–80 μg/mL), ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12589822
reach
"For example, parthenolide can affect MAP kinase signaling stimulated by LPS, and ERK and AP-1 activity stimulated by TNF-alpha and IL-1beta."
23418625
reach
"Furthermore, sLRP inhibited TNFα-induced activation of p38 MAPK and ERK/MAPK in cultured SCs, astrocytes, and microglia."
31080804
reach
"FMK also blocked TGFbeta and TNFalpha induced, ERK dependent EMT in a colon adenocarcinoma cell line."
24097826
reach
"TNF-alpha activated p65 and MAPKs (JNK1/2 and ERK1/2) which worsened the expressions of AMPK, IRS-1, PI3K-alpha, Akt and PKB, GLUT-2, GCK, glycogen synthase kinase-3 (GSK-3), PPAR-alpha and PPAR-gamma."
29310812
reach
"TNF-alpha stimulates the JNK, ERK, and p38 mitogen activated protein kinases and the NF-kappaB pathway by recruiting RIP1 and TRAF2 to the TNF receptor 1."
16291755
reach
"Collectively, these results suggest that in alveolar macrophages, O (2) (*-) generation mediates chemokine expression after TNF-alpha stimulation in an ERK dependent manner."
17704189
reach
"TNF-alpha stimulated a dose dependent increase in ERK and p38 MAPK activities that was maximal at 10 min."
9766635
sparser
"TNF- induced activation of ERK was significantly enhanced (P<0.05), while both Ang-1 and Ang-2 cooperatively induced ERK activation in MΦ IL10 ( xref and xref )."
24404127
reach
"Our data suggest that TNF-alpha and GM-CSF activate ERKs and p38 MAPK by different signal transduction pathways."
9766635
sparser
"There was no significant ERK or p38 activation by TNFα within 30 min ( Figures S1 B and S1C) and depletion of AKT1/2/3, ERK1/2, and p38 by siRNA did not block TNFα-induced mTOR activation ( Figures S2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17693255
sparser
"GEF-H1 silencing indeed reduced TNF-α-induced activation of ERK and p38 ( xref ) and prevented TACE activation ( xref )."
23389627
sparser
"GILZ overexpression also inhibited TNF-induced activation of p38, ERK, and JNK MAPKs, as well as increased expression of the MAPK inhibitory phosphatase, MKP-1."
23729444
reach
"Our studies show that TNF-alpha and IL-1beta both activate ERK1/2 in HK-2 cells."
15458430
sparser
"As is similar to JNK, the activation of ERK and p38 by TNF involves TRAF2 and RIP [ xref ]."
18954521
sparser
"These data indicate that TNF preferentially activates p38MAPKalpha and ERK in synovial membrane exposed to TNF."
16207331
sparser
"It is noteworthy that the time course activation of ERK by IL-1β and TNFα showed an identical profile with optimum activation at 24 h."
21916893
reach
"Notably, TNF-α induces ADAM17 and Src dependent EGFR activation and initiates the extracellular signal-regulated kinase (ERK)-dependent guanine nucleotide exchange factors (GEF)-H1 and RhoA signaling pathway, suggesting a mechanistic link between inflammatory and proliferative pathophysiology [27]."
33575814
reach
"Despite this, it is evident that the signalling pathways used by TNFalpha and VEGF to activate ERK and tissue factor production are different [50], as are other parallel signalling cascades."
12069833
sparser
"The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation."
11453646
reach
"In our system, we confirmed that TNF-alpha, IL-1beta, and BMP-2 alone all can activate the p38, ERK1/2, and JNK1/2 signaling in C2C12 cells."
24743742
reach
"In this work, we demonstrate that in the premalignant keratinocyte cell line HaCaT, TNF-alpha activates Akt, ERK1/2 and p38."
18557926
reach
"By doing so, TNF-alpha is still able to initiate signaling of ERK, JNK and NFkB pathways through TNFR1."
33080861
reach
"TNF-alpha activated two signaling cascades : 1) ERK1/2 and its target eIF4E and 2) Akt and its downstream effectors GSK-3, p70 (S6K), and 4E-BP1."
17971516
reach
"Another study [XREF_BIBR] demonstrated that TNF-alpha activated the extracellular signal regulated kinase and p38 pathways in MSCs, accelerated intranuclear genetic transcription and protein synthesis, and promoted MSC migration activity by combining with MSC surface receptors."
25722702
sparser
"As shown in xref , in the presence of a combination of 80 nM rapamycin and 20 nM MPA, the inhibition of TNF-α-induced ERK activation was markedly higher than that in the presence of a combination of 50 nM rapamycin and 50 nM MPA."
25673929
sparser
"In contrast, our study shows that OTUB1-deficiency in hepatocytes and the subsequent accelerated degradation of c-IAP1 (i) augmented Lm- and TNF-induced ERK activation without affecting canonical and noncanonical NF-κB activation and expression of NF-κB-dependent antiapoptotic genes (ii) induced RIPK1 and MLKL-dependent necroptosis."
33712742
reach
"After 2 days, to allow for ERK1/2 depletion, mice were treated with TNF-alpha; intestinal permeability studies were performed on day 3."
24121020
reach
"Tumor necrosis factor-alpha (TNF-alpha) induces the activation of all three types of mitogen activated protein kinase (MAPK) : c-Jun NH (2)-terminal kinase (JNK), p38, and extracellular signal regulated kinase (ERK)."
14597634
reach
"The results showed that gamma2pf weakly activated ERK and p38 MAPK but inactivated Akt in HUVECs (XREF_SUPPLEMENTARY)."
24238220
reach
"Extracellular signal regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK) and p38 were rapidly and significantly activated by TNF-alpha in HUVEC."
14720501
reach
"TNFalpha enhances ERK phosphoryation, while PD suppresses this effect (XREF_FIG)."
21048967
reach
"Interestingly, upon induction by TNF-alpha or other cytokines and growth factors, KSR-1 was known to activate MEK and then ERK by recruiting C-RAF or RAF-1 instead of A-RAF to its constitutive protein[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19563921
reach
"Exposure to 39.5 degreesC or TNF-alpha each stimulated rapid activation of p38 and ERK but the effects were not additive."
22834633
reach
"Chen et al. showed that HIV protease inhibitors (PIs) induce proinflammatory cytokines, TNF-α, and IL-6 through ER stress-mediated ERK activation, and these effects are diminished in CHOP knockout macrophages [31]."
29849928
reach
"We then confirmed that BMP-2, TNF-alpha, and IL-1beta alone can activate p38, ERK1/2, and JNK1/2, respectively."
24743742
reach
"The above observations indicate that ATM phosphorylation is a key upstream event in regulating TNF-alpha mediated ERK and p38-NF-kappaB activation."
27556690
reach
"In human neutrophils, lipopolysaccharide or TNFalpha stimulated ERK activation contributes to the delayed apoptosis, while activation of p38 MAPK induced neutrophil apoptosis in vitro."
28339172
reach
"Although TNF-alpha was a considerably stronger activator of NF-kappaB than PMA in MEFs and HEK293 cells, TNF-alpha poorly induced c-Fos, which can be explained by the inability of TNF-alpha to induce strong and sustained activation of ERK and the essential downstream transcription factors Elk-1 and CREB."
24386331
sparser
"Using the specific siRNA, we next sought to ascertain the role of TACE in the TNF-α–induced activation of ERK, which according to our earlier finding was inhibited by TAPI-1 ( xref )."
23389627
reach
"Thus, our data demonstrate a new link between the classical inflammatory IKK and IkappaB and the MEK and ERK cascades triggered by TNF-alpha."
11149911
reach
"This study investigated in 3T3-L1 adipocytes, the capacity of (-)-epicatechin to inhibit TNFalpha triggered deregulation of signaling pathways (MAPKs ERK1/2, JNK and p38, and transcription factors NF-kappaB, AP-1, and PPARgamma) that regulate genes involved in inflammation and insulin resistance."
22425757
reach
"XREF_BIBR, XREF_BIBR HIF-1alpha is highly expressed in synovial fibroblasts and infiltrating macrophages in the inflamed RA joint, where it enhances TNF-alpha- and IL-1beta-driven activation of the p38 and extracellular signal regulated kinase signaling pathways, resulting in increased IL-33 expression."
27774466
sparser
"Based on different responses to EGF or TNF in ovarian cancer cells (Figures  xref , xref , xref , xref and xref ), we compared those signaling components previously related with EGF- or TNF-activated Akt, Erk and IκB in ovarian cancer cells."
23800251
sparser
"Single-drug treatment and the combination of 20 nM rapamycin and 80 nM MPA did not inhibit TNF-α-induced ERK activation."
25673929
reach
"For each pathway TNF activated IKK, JNK, p-38, and ERK in control cells as expected and shown previously [42,45]."
16723255
reach
"The observation that TNF leads to activation of p38MAPKalpha and ERK in the synovial membrane indicates a potential role for pharmacological inhibition of these two MAPKs in blocking the deleterious effects of TNF on the joint."
16207331
reach
"As described herein, TNF-alpha activates PKCdelta, ERK1/2, and JNK2 in RA synovial fibroblasts."
20131228
sparser
"For example, TNF activates the MEK–ERK, IKK–NF-κB, JNK, and p38–HSP27 signaling pathways and the caspase cascade, whose integrated activities specificity hepatocyte responses to TNF in a context-sensitive manner."
19964679
reach
"Further experiments will be required to determine whether these upstream kinases and phosphatases are involved in Rosi mediated suppression and TSA mediated modulation of TNFalpha induced ERK activation and lipolysis."
23951179
reach
"TNF-alpha and IL-1alpha activated all p42/44 (MAPK), p38 (MAPK), and p54 (JNK) pathways as determined by immunoprecipitation kinase assays using specific antibodies and substrates."
9353295
reach
"In differentiated 3T3-L1 adipocytes, we confirm that in isolation, either insulin or TNFalpha produce dose dependent ERK activation."
29661693
reach
"To examine the effect of the TNF-alpha and IL-1beta-activated p38 and ERK1/2 pathways on Runx2 expression and activation, C2C12 cells were treated with BMP-2 and TNF-alpha and IL-1beta in the presence or absence of p38 and ERK1/2 inhibitors."
24743742
sparser
"These results suggest that notoginsenoside R1 inhibits TNF-alpha-induced ERK activation and subsequent fibronectin overexpression and migration in HASMCs by suppressing NADPH oxidase-mediated ROS generation and directly scavenging ROS."
16632126
reach
"Collectively, our results identify the adaptor Lnk as a negative regulator in the TNFalpha signaling pathway mediating ERK inhibition and suggest a role for Lnk in the interplay between PI3K and ERK triggered by TNFalpha in ECs."
16644735
reach
"Conclusion Combined hypoxia and TNF-alpha could promote HPMVEC apoptosis by activating STAT3 rather than ERK1/2."
27363268
reach
"TNF-alpha overexpression increased ERK1/2 and Egr1 signaling in nociceptive tissues."
26894912
reach
"In conclusion, we report that inhibition of HDACs 1 and 2 attenuate TNFalpha activated JNK and ERK signaling; this partially contributes to inhibition of inflammatory gene expression."
30203485
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"Within 15 minutes, TNF-alpha increased ERK1/2 and JNK1/2 activities, which immediately returned to basal levels due to increased MKP-1 activity [XREF_BIBR]."
24253595
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"NQO2 is also required for TNF-induced activation of ERK1/2 in keratinocytes xref ."
23554738
sparser
"Our results show that IL-4 modestly inhibited JNK/SAPK and ERK activation by TNF-alpha."
9918806
reach
"We show that tumor necrosis factor-alpha (TNF-alpha), a potent inflammatory activator of endothelium, leads to activation of MAP kinases ERK, p38, and JNK in human umbilical vein endothelial cells (HUVEC)."
9920834
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"TNF activates ERK and was used as a positive control."
30261438
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"The access of plasma HDL to putative binding proteins in the endothelial cells may modulate TNF-α-mediated activation of NF-κB/AP-1 signaling cascades through interrupting activation of extracellular [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12479867
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"TNF-α promotes activation of p38 and JNK, but is reported to only cause minimal activation of ERK."
25637801
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"For instance, it is known that TNFalpha can induce rapid and transient activation of ERK, JNK, and p38 MAPK (Wang and Brecher, 1999)."
12213555
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"In rat adult VSMCs, adenoviral over-expression of UCH-L1 inhibited TNFalpha induced activation of ERK and DNA synthesis."
19945429
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"TNF-alpha induced ERK1/2, p38, and JNK phosphorylation in U87MG cells, reaching a maximum after approximately 10 min of exposure and then decreasing (XREF_FIG)."
32782234
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"TNF-alpha can simultaneously activate several MAPKs family members (P38 MAPK, ERK, and JNK) and was used to treat HeLa cells at the concentration of 10 ng/ml for 2 h. TTP became extensively diffused in the cytoplasm and did not localize to PBs (XREF_FIG), while the focal pattern of PBs was preserved under TNF-alpha stimulation (XREF_FIG)."
29444957
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"To investigate if the proinflammatory cytokine TNFalpha modulates ERK activation in muscle cells, C2C12 myotubes (5 days in DM) were treated with TNFalpha for 48 h."
21048967
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"SPE Suppresses TNF-α-Induced EGFR-Independent ERK1/2 Activation."
33096942
sparser
"The TNFalpha-induced activation of ERK1/2 was specifically prevented by compound PD 98059 a specific inhibitor of the MAP kinase kinase MEK1/2."
11478736
sparser
"TNF-alpha concomitantly activated the p42/44 extracellular signal-related kinases and induced nuclear factor-kappaB activation in the lung."
10070113
reach
"Although ERK and AKT inactivation was also noted in the presence of SHH inhibitors, these kinases were not significantly activated upon TNF-alpha stimulation of IEC-6 cells (in colon cancer cells HCT-116, ERK and AKT were significantly activated by TNF-alpha and significantly inactivated by SHH inhibitors; data not shown)."
26716648
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"For example, TNF activates the MEK–ERK, IKK–NF-κB, JNK, and p38–HSP27 signaling pathways and the caspase cascade, whose integrated activities specify hepatocyte death responses to TNF xref , xref ."
20361094
reach
"Subsequently, TNFalpha activated ERK, JNK and p38 in apoptosis and autophagy, in which ERK and JNK played a promoting role whereas p38 played an inhibiting one."
18796294
reach
"Furthermore, the TLR4 antagonist, LPS- Rhodobacter sphaeroides (an MD-2 antagonist) and TAK-242 (a TLR4 signaling inhibitor) significantly inhibited NPM1 induced TNF-alpha production by differentiated THP-1 cells as well as reducing ERK1/2 activation."
33335727
reach
"In contrast, TNF stimulation of Tpl2 deficient MEFs results in defective activation of JNK, p38, ERK1/2 as well as NFkappaB, indicating a cell type specific role for TPL-2."
22017429
sparser
"Jijon HB et al. reported that TNF-α induced ERK and EGFR activation [ xref ] and Andrianifahanana M et al. reported that TGF-β induced EGFR activation [ xref ]."
23651618
reach
"Pretreatment of colon cancer HT-29 cells with HT was also successful in the decrease of NF-ĸB expression by modulating Akt/PKB and ERK 1/2, which was induced by TNF-α [103]."
32093046
sparser
"Meanwhile, similar results were gained in catalase treatment, which inhibited the TNF-α-induced activation of p38, JNK, and ERK in the CAVSMCs."
33791345
sparser
"Further experiments will be required to determine whether these upstream kinases and phosphatases are involved in Rosi-mediated suppression and TSA-mediated modulation of TNFα-induced ERK activation and lipolysis."
23951179
reach
"Furthermore, several studies have demonstrated that TNFalpha can activate ERK signaling pathways in various types of cells."
28986096
sparser
"In agreement with these reports, we found that cAMP elevation also suppresses TNF-α-induced ERK and JNK activation in human skin fibroblasts."
20357815
reach
"Both the leptin and the TNFalpha induced stimulation of PI3K-C2alpha activity were blocked by PD98059, suggesting that activation is ERK dependent in response to these cytokines."
12788079
sparser
"To determine the possible regulatory role of NIK in the MAP kinase activation, the effect of siRNA knockdown of NIK on TNF-α–induced activation of ERK1/2 and p38 kinase was examined."
26948423
reach
"In innate inflammation, tumor necrosis factor (TNF) activates mitogen-activated protein kinases ERK and P38, which in turn activate cyclic AMP-responsive element-binding protein (CREB) downstream."
29802217
sparser
"Furthermore, TNF-α-induced activation of NF-κB and ERK was reversed by CPT in a dose-dependent manner."
27382351
sparser
"Activation of ERKs by IFNγ and TNFα also affected STAT1 and NF-κB signaling through modulation of serine phosphorylation."
24391115
reach
"In this model, ATM is the key up-steam regulator of TNF-alpha activated ERK and p38-NF-kappaB pathway, which play a vital role in promoting lung cancer cell migration by up-regulating MMP-13 expression."
27556690
sparser
"TNF-α-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) was reduced by EFNB1-overexpression."
24098442
reach
"However, rapa-ECs displayed heightened basal and TNF induced activation of ERK1/2 (XREF_FIG)."
24516119
sparser
"IL-1β or TNFα activates downstream ERK1/2 and C/EBPβ in various cells [ xref , xref , xref ], and our data show that ERK1/2 are involved as the upstream regulators of CREB and C/EBPβ signaling following cooperative stimulation of mouse adipocytes by IL-1β and TNFα."
| PMC
sparser
"Activation of ERK by TNF was intact but enhanced in Sam68 knockout cells ( xref )."
21620750
reach
"Western blot analysis showed that TNF-alpha activated the extracellular signal regulated kinase (ERK), and inhibitors of the ERK specific mitogen activated protein kinase pathway (PD98059 or U0126) blocked TNF-alpha induction of TGF-beta (1) mRNA and protein."
15653932
reach
"TNFalpha also activated ERK1/2."
16141211
trips
"ERK activation was also required for TNF-alpha-stimulated DNA synthesis but likewise TNF-alpha-induced ERK activation was not blocked by inhibition of SphK."
17114809
sparser
"Extracellular regulated kinase (ERK) activation by TNF-α seems to mediate the decrease in UCP-1 expression, but not that of adipogenic genes [10] , although they are also negative regulators of these[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12044870
sparser
"Western blot analysis showed that TNF-alpha activated the extracellular signal-regulated kinase (ERK), and inhibitors of the ERK-specific mitogen-activated protein kinase pathway (PD98059 or U0126) blocked TNF-alpha induction of TGF-beta(1) mRNA and protein."
15653932
sparser
"These resveratrol derivatives inhibited TNF-α-activated ERK1/2 and JNK1/2 without affecting p38 phosphorylation."
30389230
reach
"Chen et al. showed that HIV protease inhibitors (PIs) induce proinflammatory cytokines, TNF-alpha, and IL-6 through ER stress mediated ERK activation, and these effects are diminished in CHOP knockout macrophages [XREF_BIBR]."
29849928
sparser
"At 100 μmol/L, the ERK1/2 inhibitor PD 98059 inhibited TNF-α–induced activation of ERK1/2, as assessed by kinase activity (C), and prevented the decrease in TER (D) and increase in inulin flux (E)."
24121020
reach
"Exogenous IL-18BPa-Fc significantly reduced TNF-alpha induced phophorylation of ERK1/2."
20131228
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"Treatment with either the PAR1 inhibitor, PZ-128, or the MMP1 inhibitor, FN-439, had no effect on TNFα activation of phospho-ERK1/2 or phospho-JNK."
29622563
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"TNFalpha significantly increased permeability and induced p38 and ERK MAPK activation compared with controls (P < 0.05)."
12095140
sparser
"To verify that p38 activation is indeed an effector of GEF-H1 in mediating ERK activation, we asked whether the inhibition of TNF-α–induced ERK activation observed when GEF-H1 was silenced can be overcome by overexpressing p38."
23389627
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"TNF-alpha or IL-1 alone activated ERK1/2, p38, and JNK maximally at 15 min in HUVEC."
11353829
reach
"Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells : possible participation in TNF-alpha modulation of ERK 1/2."
15979106
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"A novel and interesting finding in our study was that TNFalpha stimulation activated ERK through IKK."
21216243
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"Even though TNF-alpha also activated all MAPKs (ERK1/2, p38 and JNK), minocycline differentially affected these kinases to either inhibit or stimulate their activation."
31266502
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"XREF_BIBR XREF_BIBR - XREF_BIBR Studies have found that the ERK pathway is not only involved in the regulation of cell responses induced by growth factors, but is also activated by TNF-alpha, IL-1, and others, and plays an important regulatory role in cellular responses induced by stimulation of stress and bacterial products."
32456598
trips
"GILZ overexpression also inhibited TNF-induced activation of p38, ERK, and JNK MAPKs, as well as increased expression of the MAPK inhibitory phosphatase, MKP-1."
23729444
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"Since TNFalpha was able to activate Akt, ERK and P38 MAPK simultaneously, we determined what the net effect of these signaling pathways will be on hMEC survival, apoptosis and proliferation."
25963668
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"Microarray technology has been used to study the effects of TNF-alpha stimulated MEK and ERK signaling on global chondrocyte gene expression, resulting in the discovery that among the TNF-alpha modulated genes, proinflammatory genes are MEK and ERK independent, while genes encoding proteins with proteinase activity and HA binding activity, contributing to matrix catabolism, are MEK and ERK dependent."
21826801
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"Although highly speculative, ERK 1/2 p44, which is activated only by TNF-alpha, but not by CCL3, may represent a selective target for the pharmacologic manipulation of neutrophils activities, such adh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18164590
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"By comparison, we included the NF-κB inhibitor emodin, which did significantly reduce TNF-induced ERK activation ( Fig. 1 A)."
17292586
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"We therefore tested whether TNFalpha induced ERK activation requires extracellular PDIs."
24103565
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"We also found that human TNF-α activated JNK, ERK and P38 in PIECs (Fig.  xref a)."
31307477
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"To exclude a delay in signaling, we also found that TNF-alpha failed to activate ERK1/2 in ClC-3 null SMCs at 10 and 15 minutes after stimulation (data not shown)."
21071705
sparser
"Tumor necrosis factor-alpha rapidly and transiently activated ERK1/2 and JNK in fibroblasts, whereas the activation of p38 MAPK was more persistent."
12060661
reach
"Analyses of Nfkb1 SSAA and SSAA macrophages, in which the IKK target serine residues on NF-kappaB1 p105 are mutated to alanine, revealed that TPL-2 regulates TNF production independently of IKK induced NF-kappaB1 p105 proteolysis and ERK1/2 activation, while still associated with NF-kappaB1 p105 and ABIN-2 [XREF_BIBR]."
23557442
reach
"Thus, ERK1/2 pathway inhibitors, U0126 and PD98059, decreased TNFalpha production induced by wear particles with adherent endotoxin with dose dependencies similar to those required for inhibition of wear particle induced ERK1/2 activation."
18651635
reach
"Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells."
18822184
reach
"TNF-alpha increased ET-1 via c-Jun NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase (MAPK), but not extracellular signal regulated kinase."
20138622
sparser
"Thus, in order to narrow down the target candidates of SPE, we examined the effect of SPE on TNF-α-induced EGFR-independent ERK1/2 activation."
33096942
reach
"We found that TNF predominantly activates p38MAPKalpha and ERK in the synovial membrane, whereas JNK activation is less common."
16207331
sparser
"We found that KS cell growth factors oncostatin M, sIL-6R/IL-6, TNFalpha, and IL-1beta all activate ERK1/2, and selective blockage of this kinase by PD98059 resulted in a profound inhibition of the cytokine-induced KS cell growth."
10543991
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"This protein can modulate the tumor necrosis factor-alpha (TNF-alpha) activated NF-kappa beta, MAPK, ERK1/2, JNK, and p38 pathway by interacting with TNFR1."
22529996
sparser
"In our study, F. alocis challenge did not affect TNFα-induced ERK1/2 activation, and when apoptosis was tested, the pro-survival effect of the cytokine was not impaired."
32373107
sparser
"The activity of p38 MAPK appeared to be regulated by TRAF2 that indirectly interacts with the DD. (iii) RIP2, the receptor-interacting protein 2, has also been shown to mediate TNF-dependent ERK1/2 ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12401196
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"Because TNF-alpha has been shown to activate MAP kinases ERK1/2 and p38 kinase in various cell types, 24,25 these two kinase pathways were targeted."
24121020
sparser
"Among the top 15 DEGs, we selected MMP-9 and Madcam1 , i.e. two genes involved in cell motility processes, and confirmed their regulation by TNF-α-induced ERK activation."
31600735
sparser
"The three mammalian ERK families activated by TNF are: the mitogen-activated protein kinases (MAPKs), the c-Jun N-terminal kinases (JNKs), and p38MAPK."
11557044
reach
"IL-1beta and TNF-alpha stimulated FLSC extracellular signal regulated kinase (ERK) activation as well as MMP-1 and -13 release."
14634122
reach
"As PL-PTX has been reported to induce ovarian tumor cell apoptosis via the TNF induced ERK and AKT signaling pathway, PL-PTX may serve as an efficient anticancer drug for the treatment of ovarian cancer."
29620264
reach
"We have previously shown that tumor necrosis factor (TNF) induced the up-regulation of the sialyltransferase gene ST3GAL4 (alpha2,3-sialyltransferase gene) BX transcript through mitogen- and stress activated kinase 1/2 (MSK1/2), extracellular signal regulated kinase (ERK) and p38 mitogen activated protein kinase (MAPK) signaling pathways."
27821620
sparser
"In lung epithelial cells, α-tocoherol blocks TNFα activation of NFkB, MAPK, and ERK [ xref ]."
20923401
reach
"TNF-alpha activated ERK and increased NF-kappaB promoter activity."
20049872
trips
"Two modes of ERK activation by TNF in keratinocytes: different cellular outcomes and bi-directional modulation by vitamin D. Inflammation, elicited in the skin following tissue damage or pathogen invasion, may become chronic with deleterious consequences."
18080320
reach
"We verified that ERK signaling is activated by TNF-α (100 ng/ml) in B16-F0 and B16-F10 cells, while antibody-mediated TNF-α inhibition significantly decreased this activation (Figure 4B)."
31600735
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"TNFα activates NFκB, ERK, JNK and caspase 8 pathways thereby initiating inflammatory and apoptotic processes."
25180012
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"50 The TNF like weak inducer of apoptosis (TWEAK) has a neuroprotective role in the central nervous system, since treatment with recombinant TWEAK or expression of its receptor Fn14 induced hypoxic and ischemic tolerance through TNFalpha induced ERK1/2 activation."
23412386
sparser
"In vivo, overexpression of TNF induced activation of p38MAPKalpha and ERK in the synovial membrane, whereas activation of JNK was less pronounced and rarely observed on immunohistochemical analysis."
16207331
reach
"The levels of TNF-alpha production at T. vaginalis MOI 2 for 2 hr were 11-fold higher than that of the control (610 +/-55 pg/ml at 4 hr vs. 52 +/-8 pg/ml at control; P < 0.001) T. vaginalis infection induced activation of AKT, ERK1/2, p38 MAPK, and JNK1/2 in SiHa cells."
26323834
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"Likewise, Erk1/2 activation was also absent in these cells upon EGF, PDGF or TNF stimulation [XREF_BIBR], while overexpression of caspase-8 led to enhanced TNF induced Erk1/2 activation [XREF_BIBR]."
27101103
reach
"A previous study reported that TNF-alpha promotes ASMC proliferation, which was mediated via the phosphatidylinositol 3-kinase signaling pathway, and the p38 and extracellular signal regulated kinase 1/2 mitogen activated protein kinase (MAPK) signaling pathway."
27108806
reach
"Macrophages from Tpl2 knockout mice are defective in ERK1/2 activation induced by TNF, while activation of other MAPKs and NFkappaB remain unaffected."
22017429
reach
"Further analysis revealed that SR-A stimulated TNF-alpha synthesis in macrophages via the caveolin- instead of clathrin mediated endocytic pathway linked to p38 and JNK, but not ERK, signaling pathways."
23703615
sparser
"TNFalpha induced p38 and ERK activation, whereas oridonin triggered only ERK activation."
16418769
reach
"TNF-alpha itself can also activate ERK1/2."
27695399
reach
"TNF-alpha augmented the activation of NF-kappaB, ERK and JNK, and promoted MSC adhesion to human umbilical vein endothelial cells; however, the inhibitors of NF-kappaB, ERK and JNK did not affect this process in these cells."
27221006
sparser
"Both approaches efficiently prevented TNF-α–induced ERK activation ( xref , compare lanes 1–4)."
23389627
reach
"TNFα also activates JNK and ERK1/2 pathways."
25180012
sparser
"Activation of PKC is a key step in ERK activation by TNF reverse signalling, and PKC activation has been shown to mediate the effects of CD40L reverse signalling on dendrite growth in the CNS."
30337376
reach
"Furthermore, TNFalpha activation of Erk was abolished by a dominant negative Rac mutant, Rac17N, or by an activated Rac mutant, Rac12V."
11453646
reach
"These results further prove that TNF-α in the RN plays a crucial role in the development of abnormal pain, and the algesic effect of TNF-α is initiated through activating NF-κB, ERK and p38 MAPK."
24161765
reach
"As expected, TNFα induced the activation of MAPK signaling molecules—ERK1/2, p38, and JNK1/2 (Figure 3A)."
33827252
reach
"Furthermore, mouse embryonic fibroblasts from KSR-knockout mice have defective activation of ERK by TNF-alpha and interleukin-1 [XREF_BIBR]."
19091303
sparser
"Next we asked whether the requirement for Rac is specific for TNF-α–induced ERK activation."
23389627
sparser
"Furthermore, we observed that BMC-NPs upregulated the phosphorylation of protein kinase B (Akt) in the presence of IL-1β, and reduced the phosphorylation of TNF-α-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in the chondrocytes."
32977476
reach
"This nucleoside also participates in TNF-alpha modulation of ERK 1/2."
15979106
reach
"43 Tselepsis and colleagues reported that TNFalpha mediated upregulation of the c-MYC oncogene, via beta-catenin and a MAPK (p38 and ERK) dependent pathway in CACO2, a cell line which differentiates i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12965278
sparser
"Activation of ERKs by IFNγ and TNFα also affected STAT1 and NF-κB signaling through modulation of serine phosphorylation."
26671823
sparser
"However, TNF-α-induced activation of ERK1/2, JNK and IKK in adipocytes is rapid and transient [ xref , xref ], whereas detection of TNF-α-induced lipolysis takes >6 h."
18037376
reach
"In primary chondrocytes from this tissue, TNF-alpha stimulated activation of ERK, p38, and JNK MAPKs prior to MMP-13 induction."
12878172
reach
"Many independent researchers using cell based studies and different animals models established that TNF-alpha induces the activity of MAPKs (ERK1/2, p38 and JNK) and other kinases such as IKKbeta, PKC, mTOR and its downstream effector, S6K which in turn phoshorylate IRS1 at Ser 307 resulting in interruption of insulin signaling XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
26468734
reach
"Owing to TNF-alpha ' effects on ATM, ERK, p38 and p65 activation (XREF_SUPPLEMENTARY), the inhibition of ERK or p38 decreasing TNF-alpha induced p65 activation (XREF_SUPPLEMENTARY) indicate that ATM might play a potential role in TNF-alpha induced ERK and p38-NF-kappaB activation."
27556690
reach
"Interestingly, in articular chondrocytes and skeletal muscles, TNFalpha stimulates the activation of three subclasses of MAPKs : ERKs, p38, and JNKs XREF_BIBR, XREF_BIBR."
24324544
reach
"RESULTS: We studied both apathogenic (Tula and Topografov) and pathogenic (Puumala and Seoul) hantaviruses for their ability to regulate cellular signaling pathways and observed a direct virus-mediated down-regulation of external signal-regulated kinases 1 and 2 (ERK1/2) survival pathway activity, which was dramatically enhanced by TNF-α."
18822184
sparser
"We have previously shown that PC can inhibit the TNF-α-induced activation of the MAPkinases ERK and p38 [ xref ]."
19594939
sparser
"Since TNFα was able to activate Akt, ERK and P38 MAPK simultaneously, we determined what the net effect of these signaling pathways will be on hMEC survival, apoptosis and proliferation."
25963668
reach
"TNF-alpha caused an activation of both ERK1/2 and p38 kinase, as evidenced by the phosphorylation of ERK1/2 and p38 kinase."
26948423
sparser
"Considering that the p44 and p42 extracellular signal-related kinases (ERK 1 and 2) can be activated by TNF in BAE cells and that their activation is associated with inhibition of apoptosis in some c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12639717
sparser
"Further studies indicated that elevation of cAMP before or after TNF-α treatment might attenuate MMP-1 expression through the suppression of TNF-α-induced activation of extracellular signal-regulated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20357815
reach
"Western blot analysis of ERK phosphorylation demonstrated that U0126 inhibited TNFalpha induced ERK signaling (XREF_FIG)."
30203485
reach
"TNF-induced anti-apoptotic pathways include PI3K/AKT, ERK/MAPK, and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), whereas pro-apoptotic TNF induced-pathways include p38 MAPK and stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) [15,16,17]."
31426531
reach
"By using the EGF receptor (EGFR) tyrosine kinase inhibitor, AG1487 and the Src family inhibitor, PP-1, we established that TNF activated ERK in an EGFR and Src dependent and an EGFR and Src independent modes."
18080320
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"At present, mechanisms by which ERK activation was prolonged by TNF are not known."
12063024
reach
"Studies have shown that IL-2, IL-4, IFN-gamma, or TNF-alpha activates Erk1/2 and PI3K/Akt/S6K1 pathways [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
27235588
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"In this study, we examined the effects of KSR deficiency on ERK activation by stress stimuli and show that ERK activation by TNF, IL-1, and sorbitol is attenuated in the absence of KSR1."
17056543
reach
"The ERK pathway is activated mainly by growth factors (epidermal growth factor, EGF, and platelet derived growth factor, PDGF) and cytokines (IL-1beta and TNF-alpha), and its activation is related to the stimulation of tyrosine kinase receptors [XREF_BIBR, XREF_BIBR]."
26998193
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"Through binding to and activating TNFR1 on VEC surface, TNFalpha can promote the activation of transcription factor nuclear factor- kappaB (NF-kappaB) and p-38 and ERK1/2 MAPKs (Mitogen activated protein kinases) signaling pathways, thereby up-regulating the expression of cell adhesion molecules (CAMs), including intracellular adhesion molecule-1 (ICAM-1) and E-selectin, which are involved in the processes of leukocyte attachment and transmigration."
24991819
sparser
"We further investigated the effects of cAMP pathway and GSK-3 activity on MMP-1 expression but focused on their effects on MMP-1 expression after the activation of ERK and JNK by TNF-α had already occ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20357815
reach
"TNF- induced activation of ERK was significantly enhanced (P < 0.05), while both Ang-1 and Ang-2 cooperatively induced ERK activation in MPhi IL10 (XREF_FIG and XREF_SUPPLEMENTARY)."
24404127
reach
"To address this issue, ATM inhibition was performed and TNF-alpha induced ERK and p38-NF-kappaB activation was evaluated."
27556690
reach
"Hantaviruses and TNF-alpha act synergistically to induce ERK1/2 inactivation in Vero E6 cells.Hantaviruses (Family Bunyaviridae, Genus Hantavirus) are viruses which chronically infect rodents and insectivores with no apparent disease but in humans they cause two major clinical symptoms: HFRS in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas."
18822184
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"(II) TNF induced ERK activation is strongly diminished in the absence of FADD."
16129431
reach
"Thus, compound disruption of the Mlk2 and Mlk3 genes causes markedly reduced activation of JNK and p38 MAP kinases, but does not alter TNFalpha stimulated ERK activation [XREF_BIBR]."
24647229
reach
"TNF-alpha activated ERK1/2, JNK, and p38 maximally at 15 min in HUVEC."
12686737
sparser
"In addition, while Apigenin and Luteolin slightly inhibited TNFα-induced JNK activation, they had no effect on TNFα-induced activation of ERK and p38."
21443976
sparser
"Role of ClC-3 in TNF-α-induced activation of ERK1/2."
21071705
sparser
"In intestinal epithelial cell line Caco-2, ERK1/2 activation induced by TNF-α leads to a significant enhancement in paracellular permeability [20] , whereas IL-1β increases paracellular permeability [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26148935
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"Furthermore, AMF suppressed IL-1β and TNF-α levels and increased IL-10 levels in pleural exudate by blocking the proinflammatory NF-κB, signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase (ERK) pathways induced by Car."
35237153
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"In human neutrophils, TNFalpha stimulation results in activation of both p38 and ERK1/2, which are involved in the production of inflammatory cytokines and chemokines independently of NF-kB activation."
32373107
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"Although none of the treatments affected ERK phosphorylation after 1 h (data not shown), by 6 h both TVX and TVX and TNF treatments led to an increase in ERK activation compared to cells treated with [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25748550
reach
"We compared and analyzed the effects and molecular mechanisms of action of 2 stimuli, phorbol 12-myristate 13-acetate (PMA) and tumor necrosis factor (TNF)-alpha, which were shown to activate NF-kappaB and ERK signaling to distinct degrees in diverse cell types."
24386331
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"Caspase-8 was also found to be essential for TNFalpha induced activation of the Erk pathway in these cells (data not shown)."
19470771
sparser
"We compared the effect of Rac silencing on ERK activation induced by TNF-α and plasma membrane depolarization."
23389627
sparser
"In conclusion, PPAP sequence of TNFR1 seems to have significant role in initiating signaling events resulting in activations of ERK, AKT, JNKs and p38 kinases by TNFα."
33907493
sparser
"ERK activation was also required for TNF-alpha-stimulated DNA synthesis but likewise TNF-alpha-induced ERK activation was not blocked by inhibition of SphK."
17114809
reach
"One kinase of the MAPK, p38, was reported to be increased in animal models of neuropathic pain.15 TNF-α activates multiple signaling pathways, including the p38 MAPK pathway,16 which is recognized as an important regulator of inflammatory pain,17 although TNF-α can also activate ERK or c-JUN of MAPK."
28579824
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"Previously, other authors have indirectly suggested that ERK1/2 MAPK could participate in NF-kappaB activation in human neutrophils, mainly because ERK1/2 is activated by TNF-alpha, a potent NF-kappaB activator [XREF_BIBR, XREF_BIBR]."
26634216
sparser
"We found that TNF predominantly activates p38MAPKα and ERK in the synovial membrane, whereas JNK activation is less common."
16207331
reach
"Moreover, TNFalpha stimulated both the NF-kappaB and mitogen activated protein (MAP) kinase (extracellular signal regulated kinase, c-Jun NH (2)-terminal kinase, and p38 MAP kinase) signaling pathways in astrocytes."
10753884
reach
"The three mammalian ERK families activated by TNF are : the mitogen activated protein kinases (MAPKs), the c-Jun N-terminal kinases (JNKs), and p38MAPK."
11557044
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"PTX alone had no effect on ERK1/2 activity nor did it affect TNF induced ERK1/2 activity."
30261438
sparser
"Although our results are similar to those of studies in human knee chondrocytes where TNF-α induced ERK, p38, and JNK activation, no correlation with their target genes (such as MMP-13) was establishe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12878172
reach
"To examine whether the inability of TNF to induce IKK, p38, and to some degree JNK and ERK during S-phase is due to reduced TNF receptor or signaling molecules TRAF2 and RIP, we determined their prote[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16723255
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"In contrast, TNF-alpha did not activate the extracellular signal regulated kinase (MAP kinase) p42, nor did it elicit a mitogenic response."
10501211
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"Also, TNF induced ERK activation is much stronger in Sam68 knockout cells than the wild type cells."
21620750
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"PF inhibited TNFalpha stimulated adipocyte lipolysis in a dose dependent manner, which was compatible with suppressed phosphorylation of TNFalpha activated ERK1/2 and preserved downregulation of perilipin."
19396840
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"In U937 leukemia cells, TNF-α activates ERK in a SphK-dependent manner: DMS inhibits TNF-α-induced activation of ERK and exogenous S1P activates ERK independently of TNF-α [56] ."
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"By comparison, we included the NF-kappaB inhibitor emodin, which did significantly reduce TNF induced ERK activation."
17292586
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"A role for the kinase activity of RIPK1 in TNF-induced ERK activation has been suggested ( xref )."
25015821
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"TNF-α-induced ERK1/2 activation was inhibited by quercetin in a concentration-dependent manner (10–80 μg/mL) ( Fig. 1B )."
12589822
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"Besides classical TNF-α/NF-κB signaling, it is widely accepted that TNF-α activates MAPK and Erk1/2 signaling."
34504840
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"EGF and TNFalpha ligands stimulate ERK, JNK and p38 MAPK cascades, the PI3K and AKT pathways, and the NFkB cascade."
28736575
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"TNF-alpha is known to activate JNK2, PKC, ERK1/2, and NFkappaB in RA synovial fibroblasts."
20131228
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"Therefore, we have analyzed TNF induced ERK activation in various human and murine cell lines and show that it occurs in a cell-type-specific manner."
16129431
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"The activation of ERK1/2 by TNF-α leads to an increase of Egr-1 expression and subsequent elevation of p35 expression ( xref )."
21253436
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"The results of three independent experiments are presented PD98059), while activation of ERK1/2 by TNFα was abolished under these conditions (Fig. 1e )."
34741187
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"Furthermore, TNFalpha activation of Erk was abolished by a dominant negative Rac mutant, Rac17N, or by an activated Rac mutant, Rac12V. These findings suggest that Rac is activated by a mechanism that is at least partly dependent on PI3K in TNFalpha stimulated cells and plays a critical role in activation of the Erk signaling pathway."
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"In addition, PP1 substantially inhibited the IL-2beta- and TNFalpha-dependent activation of Erk 1/2 and Akt."
12483539
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"In the priming phase, the transient activation of the p38 MAPK, ERK, and PI 3-kinase/Akt pathways by TNFalpha was blocked by prior exposure of the neutrophils to heat, but GM-CSF-induced activation was unaltered by heat."
17763432
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"Our results suggested that TNF-alpha promoted ERK and Akt activation in HaCaT cells."
26382065
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"Interestingly, while the activation of p38 MAPK by IL-1β, fibroblast growth factor 1 (FGF-1), or FGF-2 was sensitive to dexamethasone or fluticasone propionate (Fernandes, et al., 1999; Tran, et al., 2005; Willems-Widyastuti, et al., 2013), the activation of ERK1/2 MAPK by TNF was found to be insensitive to GCs (Fernandes, et al., 1999; Robins, et al., 2011)."
32473159
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"Characteristics of components related with differential EGF- or TNF-activated Akt, Erk and IκB in ovarian cancer cells."
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"In cells pretreated with the ERK1/2 inhibitor FR180204, TNF-alpha failed to induce phosphorylation of ERK1/2, as shown in XREF_FIG, suggesting that TNF-alpha activates ERK1/2 in synovial fibroblasts."
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"(iv) MADD, a TNFR1 interacting DD protein has been reported as a regulator of TNF induced ERK1/2 and cPLA 2 activation [22]."
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