IndraLab

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TGFB activates phosphorylated SMAD3. 5 / 5
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"As shown in Fig. 2 G, the phosphorylated SMAD3 proteins were induced by TGF-beta and their levels were similar in control cells and EED knockdown cells."
25264103
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"XREF_BIBR We found that treatment of C2C12 cells with recombinant hHGF protein increased the RNA level of miR-206 while decreasing the amount of phosphorylated Smad3 protein induced by TGF-beta, indicating that HGF might counteract the biological consequences generated by TGF-beta."
30195792
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"As shown in XREF_FIG, the phosphorylated SMAD3 proteins were induced by TGF-beta and their levels were similar in control cells and JARID2 knockdown cells."
25542019
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"Human MRC-5 fibroblasts were incubated for 1 hour with the conditioned media obtained from methacholine stimulated lung slices, followed by analysis of phosphorylated Smad-3, which is specifically activated by TGF-beta."
23840342
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"While we have previously described that loss of TGF-beta and Smad3 signaling in Col2a1-Smurf2 transgenic chondrocytes might represent a mechanism of Smurf2 induced OA in Col2a1-Smurf2 transgenic mice, Smurf2 mainly induces ubiquitination of phosphorylated Smad3 activated by exogenous TGF-beta in chondrocytes, and only slightly affects the basal level of phosphorylated Smad3 in resting chondrocytes [XREF_BIBR], indicating that Smurf2 mediated loss of TGF-beta and Smad3 signaling in chondrocytes may not be a dominant mechanism underlying Smurf2 induced OA in Col2a1-Smurf2 transgenic mice."
19481076