IndraLab

Statements

Modified FBXW8 decreases the amount of IRS1. 4 / 4
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"The evidence for a physiological role of the Cullin7-Fbw8 E3 ubiquitin ligase includes the report that overexpression of Fbw8 alone or Cullin7-Fbw8 in different cells markedly reduces the steady-state level of IRS-1 and shortens its half-life."
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"Fbw8 overexpression in Sin1 -/- was sufficient to reduce IRS-1 levels in a dose dependent manner."
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"Second, overexpression of Fbw8 and CUL7 in different cell types markedly reduced the steady-state level of IRS-1 and shortened its half-life."
18498745
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"While overexpression of either HA-Rheb or Myc-Fbw8 (lane 2) reduced the levels of endogenous IRS-1 only slightly, coexpression of Rheb and Fbw8 induced effective degradation of IRS-1 (lane 4)."
18498745