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Mutated CTNNB1 leads to the ubiquitination of CTNNB1. 1 / 1
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reach
"In CRC cells, the APC and β-catenin mutations not only prevent this normal β-catenin phosphorylation and ubiquitination but also promote abnormal β-catenin stabilization, translocation, and nuclear accumulation (Liu et al., 1999, 2002; Yang et al., 2006)."