IndraLab

Statements


CTNNB1 bound to TCF4 activates CTNNB1. 5 / 5
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"In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin and TCF signaling."

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"Similarly, the interaction between nuclear beta-catenin and TCF-4 or LEF-1 was reduced by CaSR activation, indicating an inhibitory association of beta-catenin and TCF-4 or LEF-1 in the nucleus."

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"The mechanism study revealed that TFCP2 interacted beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin and TCF signaling."

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"Overexpression of AP-2alpha in HEK293, HCT116 or HT29 cells appeared to decrease the association between TCF-4 and beta-catenin and decreased beta-catenin activity."

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"The Tcf-4 and beta-catenin transcriptional activity is inhibited by protein Icat (inhibitor of beta-catenin and Tcf-4), which blocks the interaction between beta-catenin and Tcf-4 and thereby antagonizes Wnt signaling [XREF_BIBR]."