IndraLab

Statements

APCDD1 binds CTNNB1. 5 / 5
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"Functional studies using ex vivo and in vitro OL systems, revealed that Apcdd1 promotes OL differentiation, suppresses Wnt signaling, and associates with beta-catenin."
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sparser
"Furthermore, APCDD1 expression was negatively associated with nuclear β-catenin expression and transcription factor/lymphoid enhancer binding factor 1 transcriptional activity in the present study."
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reach
"Importantly, that Apcdd1 suppresses beta-catenin dependent Wnt activation and associates with both beta-catenin and LRP6, suggests that it functions as a bridge between the proximal Wnt receptor complex and the distal nuclear effectors."
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reach
"Consistent with its expression dynamics, functional studies revealed that it is sufficient to promote OL differentiation and suppresses beta-catenin dependent Wnt activation, which is mediated by an association between Apcdd1 and beta-catenin."
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trips
"Functional studies using ex vivo and in vitro OL systems revealed that Apcdd1 promotes OL differentiation, suppresses Wnt signaling, and associates with β-catenin."
25946682