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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Kinase-active MTOR phosphorylates EIF4EBP1 on S65. 2 / 2

2 |

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bel

"12912989;17081983"

15212693

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bel

"The immunosuppressant rapamycin specifically inhibits mTOR activity and retards cancer growth. mTOR phosphorylates 4E-BP1 primarily at residues Ser65 abd Thr73. As a result, eIF4E is released from 4E-BP1 with a subsequent increase in cap-dependent translation (Mamane et al, 2004)."

16404421

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...