IndraLab

Statements


MTOR phosphorylates EIF4EBP1 on serine. 9 / 9
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sparser
"The interaction of 4E-BP1 with eIF4E is negatively regulated by mammalian target of rapamycin (mTORC1)-dependent phosphorylation of serine and threonine residues on 4E-BP1."

sparser
"It was shown that mTOR phosphorylated 4E-BP1 at serine and threonine residues in insulin-stimulated human embryonic kidney cells and these phosphorylations are inhibited by rapamycin [ xref ]."

reach
"4EBP1 is phosphorylated by mTOR at serine 65 and threonine 70 XREF_BIBR."

reach
"4E-BP1 serine 82 (S82) is phosphorylated by CDK1, but not mTOR, and the consequences of this mitosis-specific phosphorylation are unknown."

sparser
"MTOR phosphorylated PHAS-I on serine and threonine residues in vitro, and these modifications inhibited the binding of PHAS-I to eIF-4E. These studies define a role for mTOR in translational control and offer further insights into the mechanism whereby rapamycin inhibits G1-phase progression in mammalian cells."

reach
"It was shown that mTOR phosphorylated 4E-BP1 at serine and threonine residues in insulin stimulated human embryonic kidney cells and these phosphorylations are inhibited by rapamycin [XREF_BIBR]."

reach
"MTOR phosphorylated PHAS-I on serine and threonine residues in vitro, and these modifications inhibited the binding of PHAS-I to eIF-4E."

reach
"4EBP1 is phosphorylated by mTOR at serine 65 and threonine 70."

rlimsp
"MTOR phosphorylated PHAS-I on serine and threonine residues in vitro, and these modifications inhibited the binding of PHAS-I to eIF-4E."