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CYLD activates apoptotic process. 77 / 83
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"With respect to breast cancer cell growth, it has been shown previously that CYLD mediates growth suppression of the aggressive human breast cancer cell line BT549 by inducing apoptosis ( Wang et al.,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27865894
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"Furthermore, inactivation of CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer [ 17–19 ]."
31097224
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"Interestingly, CYLD-mediated apoptosis of BT549 breast cancer cells was associated with the downregulation of the anti-apoptotic gene Bcl2 ( Wang et al., 2005 ) similarly to the effect of PPAR-γ activ[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27865894
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"Moreover, exposure of CYLD knockdown HeLa cells to anti-inflammatory drugs such as sodium salicylate or prostaglandin A1, which inhibit NF-kappaB, abolished the protective knockdown of apoptosis, suggesting that loss of CYLD confers resistance to apoptosis through activation of NF-kappaB [XREF_BIBR]."
20414373
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"Results We obtained the following results : CYLD suppression enhanced proliferation , reduced apoptosis , and increased cell division of RA-FLSs and aggravated the activity of NF-kappaB in RA-FLSs ."
30285829
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"CYLD Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Regulating NDRG1."
33149672
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"We found that CYLD levels were significantly decreased in both NPC tissues and cell lines, and that CYLD overexpression inhibited NPC cell proliferation and promoted apoptosis."
33149672
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"In this study, we demonstrated that CYLD expression is downregulated in NPC tissues, and that CYLD overexpression inhibits NPC cell proliferation and promotes apoptosis, whereas CYLD knockdown reverses these effects in NPC cells."
33149672
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"CYLD Overexpression Promotes NPC Cell Apoptosis."
33149672
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"We found that CYLD overexpression increased both early and late apoptosis in CNE2 and HK1-EBV cells (XREF_FIG and XREF_FIG), whereas CYLD knockdown in HONE1 and 5-8F cells inhibited apoptosis relative to that observed in control cells."
33149672
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"Flow cytometry and immunofluorescence microscopy reveal that CYLD increases the ability of noscapine to induce mitotic arrest and apoptosis."
25897332
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"These results indicated that CYLD increased apoptosis in NPC cells, whereas CYLD downregulation inhibited this process."
33149672
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"Additionally, we observed that the CYLD specific promotion of NPC cell apoptosis was reversed by NDRG1 silencing (XREF_FIG and XREF_FIG)."
33149672
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"We then determined the molecular function of CYLD in NPC cells, finding that CYLD inhibited NPC cell proliferation but promoted apoptosis according to CYLD-overexpression and -silencing analyses, respectively."
33149672
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"Moreover, CYLD reportedly promotes TNF-alpha-Induced apoptosis and programmed necrosis in human lung cancer cells."
33149672
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"In conclusion, we demonstrated that CYLD downregulation promoted NPC cell proliferation and apoptosis resistance."
33149672
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"Then, we found that CYLD overexpression inhibited cell viability and colony formation, and promoted cell apoptosis in MMQ cells (Figure 2SB-D)."
35435104
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"Another finding of this study is the increased rate of apoptosis induced by CYLD WT both in tumoral and non tumoral human keratinocytes."
21900959
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"CYLD works synergistically with the necroptotic pathway involving RIPK1, promoting cancer cell apoptosis and exerting anti-tumor effects ."
39333335
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"To corroborate the above findings, we examined the effects of CYLD and its mutants on noscapine induced apoptosis and mitotic arrest by flow cytometry."
25897332
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"One of them is the hyperactivation of antiapoptotic signals in absence of functional CYLD in tumoral cells; 29 previously we described that CYLD C/S induced resistance to apoptosis in mouse skin tumors; 21 here we also extend this property to human skin cancer."
21900959
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"We then examined whether increasing the levels of CEP-1 and p53 could sensitize cyld-1 (tm3768) worms to DNA damage induced germ cell apoptosis in cyld-1 (tm3768) mutant worms carrying the gld-1 (op236) mutation."
27561390
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"These data indicate that CYLD is important for the ability of noscapine to induce apoptosis in ALL cells."
25897332
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"Previous studies have also revealed that CYLD suppression leads to decreased apoptosis and increased proliferation by activating NF-kappaB [ 23 , 65 ] ."
30285829
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"In the present study , we found that CYLD inhibition distinctly enhanced proliferation , reduced apoptosis , and increased the cell division of RA-FLSs and aggravated the activity of NF-kappaB in these cells , suggesting that CYLD is involved in RA-FLS hyperproliferation in RA ."
30285829
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"Consistent with the immunofluorescence results, annexin V/PI staining based flow cytometry showed that CYLD and its C/S mutant, but not its DeltaCG1 mutant, promoted both early and late apoptosis induced by noscapine."
25897332
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"Furthermore , we found that CYLD deficiency promoted cervical cancer cell proliferation , colony formation , cell migration and invasion , and inhibited apoptosis instead , whereas it is just opposite with CYLD over-expression ."
37359274
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"Firstly, we asked whether overexpression of CYLD-flag could induce cell apoptosis, which probably contributed to CYLD induced cell death."
27738385
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"Moreover, overexpression of CYLD increased TNF-alpha induced cell apoptosis in A549 cells."
27738385
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"In addition, some studies have also reported that CYLD could modulate apoptosis, for instance, it could modulate apoptosis by negatively regulating the NF-κB signaling pathway [ 19 ]; upregulation of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36442704
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"In addition to reduced proliferation, CYLD was shown to promote apoptosis in different cell types including HeLa XREF_BIBR or HaCaT cells XREF_BIBR by interfering with NF-kappaB signaling pathway."
21573132
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"Our data only showed that Es CYLD can induce hemolymph apoptosis after V. parahaemolyticus challenge of E. sinensis ."
36442704
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"Despite the previous report showing that CYLD can promote apoptosis by interfering with TNF-alpha signaling pathway XREF_BIBR, XREF_BIBR, we did not observe any differences in apoptotic rate under (1) non induced condition, (2) removal of serum, (3) when the cells were treated with TNF-alpha alone or (4) when treated with TNF-alpha together with cyclohexamide."
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"For instance, upregulation of CYLD enhanced Listeria monocytogenes -induced apoptosis in THP-1 cells and is required for cetuximab-induced apoptosis in head and neck squamous cell carcinoma [ 11 , 20 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36442704
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"This results in inhibition of NF-kappaB activation and loss of CYLD is shown to inhibit apoptosis."
29479529
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"In addition, deletion of deubiquitinating enzyme CYLD reduces the early wave of germ cell apoptosis and leads to impaired spermatogenesis [13]."
32469046
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"SMARCE1 is located on chromosome 17q21.2 and is responsible for inducing apoptosis by stimulating expression of CYLD [ 65 ] ."
33801089
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"CYLD also induces apoptosis and has been found to be underexpressed in several human cancers [XREF_BIBR]."
27923454
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"Increased expression of CYLD in BT549 cells induced apoptosis, while its suppression by small interfering RNA inhibited cell death in BAF57 expressing BT549 cells."
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"Furthermore, we uncovered a dual function of CYLD in the pathogenesis of ECM : (i) CYLD impaired activation of PKC-theta and NF-kappaB in CD8 + T cells and (ii) CYLD promoted apoptosis of endothelial cells, thereby augmenting brain pathology and preventing survival during ECM."
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"Taken together, our data show that the presence of CYLD promotes brain pathology with increased neuroinflammation and hemorrhage as well as endothelial cell activation and apoptosis."
28203236
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"The genetic deficiency of Cyld in mice attenuates the early wave of germ cell apoptosis and causes impaired spermatogenesis."
17981138
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"Thus, the loss of CYLD attenuates testicular apoptosis at early stages of spermatogenesis, resulting in heightened apoptosis and testicular degeneration at late PN stages."
17981138
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"Overexpression of CYLD following RNF166 gene knockdown eliminated mitochondrial dysfunction and apoptosis of podocytes under high glucose stimulation due to RNF166 knockdown."
37176077
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"31 It seems that the germ cells are constantly exposed to NF-kappaB stimuli, but the magnitude of NF-kappaB activation is controlled by CYLD, thereby allowing the programmed cell death to occur."
19373246
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"Song et al. showed that miR-301b was upregulated in TNBC specimens and cell lines, and inhibited the apoptosis induced by 5-FU by direct binding to 3′-UTR of CYLD lysine 63 deubiquitinase (CYLD) mRNA to activate NF-κB p65 [169]."
31766744
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"Nevertheless, the potential mechanisms to explain how A20 and CYLD promote cell apoptosis remain uncertain."
32525021
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"Increasing CYLD promotes apoptosis and increasing PNUTL enhances cell death via TGF."
23056957
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"Cosilencing of RIPK1 diminished apoptosis induced by CYLD silencing in Mel-CV and ME1007 cells, substantiating the role of RIPK1 in induction of apoptosis by silencing of CYLD."
32252875
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"In the present study, CYLD overexpression inhibited cell growth and promoted cell apoptosis in colon cancer cells, while the expression levels of p-p65 and p65 were decreased and those of p-IkappaBalpha and IkappaBalpha were increased."
32901872
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"CYLD has also been found to promote apoptosis in NPC [25]."
38287022
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"miR-362 targeted cylindromatosis (CYLD) activation of the NF-kappaB pathway induced cell growth and apoptosis tolerance in gastric cancer."
30155491
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"FCM analyses of annexin-V, APCA, and PI revealed that lentivirus-mediated inhibition of CYLD significantly prevented early and total apoptosis (LR and TR, respectively) but not late apoptosis (UR) when compared with the sh-GFP groups (Fig. 5B; LR 4.98 ± 0.94 vs. 7.15 ± 0.10, P = 0.016; UR 1.65 ± 1.14 vs. 3.51 ± 1.19, P = 0.122; TR 6.63 ± 0.21 vs. 10.67 ± 1.28, P = 0.029)."
30285829
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"Our findings underscore a putative mechanism whereby CYLD repression mediated and NF-kappaB transactivation dependent miR-19a regulatory feedback loop prevents cell apoptosis in response to OS microenvironment."
29050336
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"Our previous research has demonstrated that adult T-cell leukemia/lymphoma (ATLL) had high level of CYLD phosphorylation, down-regulating CYLD phosphorylation could increase CYLD deubiquitinase activity and then promoted apoptosis in ATLL [XREF_BIBR]."
33827598
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"We next explored the invovlement of CYLD in the resistant action of miR-19a against OS initiated apoptosis through stimulating miR-19a plus Flag-CYLD-coexpressed PC12 cells with CoCl 2 or H 2 O 2 and detecting the resultant effects."
29050336
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"In addition, CYLD overexpression markedly increased apoptosis of HCC827 and Calu-3 cells (XREF_FIG)."
29286108
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"In this study, loss-of-function and gain-of-function data show that depletion of CYLD compromises, while overexpression of CYLD potentiates PC12 cells apoptosis initiated by OS."
29050336
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"In the present study, we found that CYLD inhibition distinctly enhanced proliferation, reduced apoptosis, and increased the cell division of RA-FLSs and aggravated the activity of NF-κB in these cells, suggesting that CYLD is involved in RA-FLS hyperproliferation in RA."
30285829
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"Consistently, CYLD expressing tumors had features of reduced cell proliferation and enhanced cell apoptosis as indicated by the decreased number of Ki-67-positive cells and the increased number of caspase-3-positive cells, respectively (XREF_FIG, XREF_SUPPLEMENTARY)."
22832488
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"A few reports corroborate this, as TRAF6 (controlled by IL-1B, TLR2 and CYLD) was found to immortalize lymphocytes thereby sustaining the damage they can do without the check of CYLD mediated apoptosis [XREF_BIBR]."
25342597
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"Moreover, CYLD silencing reversed the pro apoptosis induction effect of I3C and reduced the expression ratio of Bax and bcl -2 in HSC-T6 cells."
28395284
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"But in OCI-Ly10R cells, BTK inhibitor PCI-32765 but not rituximab could reduce CYLD phosphorylation and induce apoptosis."
33827598
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"The results demonstrated that miR-454 downregulated CYLD mRNA and protein expression which increased the apoptosis rate of cancer cells."
32346424
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"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [XREF_BIBR]."
34336031
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"Furthermore we found that knockdown CYLD could reduce THP-1 cell apoptosis through negatively regulating NF-κB signaling pathway."
26545866
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"In addition, as a tumor suppressor, CYLD can promote tumor cell apoptosis by negatively regulating NF-κB signaling [54] ."
33182039
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"CYLD could enhance apoptosis through negatively regulating NF-κB signaling pathway."
26545866
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"Thus CYLD is exploited to promote macrophage apoptosis and subsequent bacterial growth."
26545866
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"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [ 26 ] ."
34336031
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"CYLD and SPATA2 both have been shown to contribute to TNF-induced apoptosis signaling."
36640323
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"Therefore, inactivation of the CYLD1 protein may contribute to oncogenesis by enhancing the degradation of proteins that suppress cell proliferation or promote apoptosis."
15086550
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"In line with a role of ubiquitylation in preserving RIPK1 in a survival mode, loss of CYLD and therefore sustained ubiquitylation was shown to block complex IIb formation and apoptosis induction [XREF_BIBR]."
27424290
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"Taken together, these results indicate that selenite triggered upregulation of CYLD transcription induced RIP1 deubiquitination and apoptosis."
24577083
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"LEF1 mediated inhibition of CYLD expression is abolished upon selenite treatment to trigger apoptosis."
24577083
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"CYLD siRNA in a HCC cell line suppressed apoptosis via the NFκB-mediated tumor necrosis factor α signaling pathway by lowering caspase-3 activity [68]."
35884607
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"Loss of CYLD inhibits cellular apoptosis by activating NF-kappaB pathway [XREF_BIBR]."
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