IndraLab

Statements

CYLD activates apoptotic process. 61 / 66
| 5 56
eidos
"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [ 26 ] ."
34336031
reach
"In the present study, CYLD overexpression inhibited cell growth and promoted cell apoptosis in colon cancer cells, while the expression levels of p-p65 and p65 were decreased and those of p-IkappaBalpha and IkappaBalpha were increased."
32901872
reach
"Increasing CYLD promotes apoptosis and increasing PNUTL enhances cell death via TGF."
23056957
reach
"Additionally, we observed that the CYLD specific promotion of NPC cell apoptosis was reversed by NDRG1 silencing (XREF_FIG and XREF_FIG)."
33149672
eidos
"Previous studies have also revealed that CYLD suppression leads to decreased apoptosis and increased proliferation by activating NF-kappaB [ 23 , 65 ] ."
30285829
reach
"This results in inhibition of NF-kappaB activation and loss of CYLD is shown to inhibit apoptosis."
29479529
reach
"We found that CYLD levels were significantly decreased in both NPC tissues and cell lines, and that CYLD overexpression inhibited NPC cell proliferation and promoted apoptosis."
33149672
reach
"The results demonstrated that miR-454 downregulated CYLD mRNA and protein expression which increased the apoptosis rate of cancer cells."
32346424
reach
"In this study, we demonstrated that CYLD expression is downregulated in NPC tissues, and that CYLD overexpression inhibits NPC cell proliferation and promotes apoptosis, whereas CYLD knockdown reverses these effects in NPC cells."
33149672
reach
"Another finding of this study is the increased rate of apoptosis induced by CYLD WT both in tumoral and non tumoral human keratinocytes."
21900959
reach
"But in OCI-Ly10R cells, BTK inhibitor PCI-32765 but not rituximab could reduce CYLD phosphorylation and induce apoptosis."
33827598
reach
"Moreover, exposure of CYLD knockdown HeLa cells to anti-inflammatory drugs such as sodium salicylate or prostaglandin A1, which inhibit NF-kappaB, abolished the protective knockdown of apoptosis, suggesting that loss of CYLD confers resistance to apoptosis through activation of NF-kappaB [XREF_BIBR]."
20414373
reach
"One of them is the hyperactivation of antiapoptotic signals in absence of functional CYLD in tumoral cells; 29 previously we described that CYLD C/S induced resistance to apoptosis in mouse skin tumors; 21 here we also extend this property to human skin cancer."
21900959
reach
"CYLD Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Regulating NDRG1."
33149672
reach
"Cosilencing of RIPK1 diminished apoptosis induced by CYLD silencing in Mel-CV and ME1007 cells, substantiating the role of RIPK1 in induction of apoptosis by silencing of CYLD."
32252875
reach
"In addition, deletion of deubiquitinating enzyme CYLD reduces the early wave of germ cell apoptosis and leads to impaired spermatogenesis [13]."
32469046
reach
"Moreover, CYLD silencing reversed the pro apoptosis induction effect of I3C and reduced the expression ratio of Bax and bcl -2 in HSC-T6 cells."
28395284
reach
"CYLD suppression enhanced proliferation, reduced apoptosis, and increased cell division of RA-FLSs and aggravated the activity of NF-kappaB in RA-FLSs."
30285829
reach
"We then determined the molecular function of CYLD in NPC cells, finding that CYLD inhibited NPC cell proliferation but promoted apoptosis according to CYLD-overexpression and -silencing analyses, respectively."
33149672
eidos
"Results We obtained the following results : CYLD suppression enhanced proliferation , reduced apoptosis , and increased cell division of RA-FLSs and aggravated the activity of NF-kappaB in RA-FLSs ."
30285829
reach
"miR-362 targeted cylindromatosis (CYLD) activation of the NF-kappaB pathway induced cell growth and apoptosis tolerance in gastric cancer."
30155491
reach
"We next explored the invovlement of CYLD in the resistant action of miR-19a against OS initiated apoptosis through stimulating miR-19a plus Flag-CYLD-coexpressed PC12 cells with CoCl 2 or H 2 O 2 and detecting the resultant effects."
29050336
reach
"Yin et al. reported that CYLD could increase apoptosis and decrease autophagy to improve the chemosensitivity to gemcitabine in bladder cancer [XREF_BIBR]."
34336031
reach
"FCM analyses of annexin-V, APCA, and PI revealed that lentivirus-mediated inhibition of CYLD significantly prevented early and total apoptosis (LR and TR, respectively) but not late apoptosis (UR) when compared with the sh-GFP groups (Fig. 5B; LR 4.98 ± 0.94 vs. 7.15 ± 0.10, P = 0.016; UR 1.65 ± 1.14 vs. 3.51 ± 1.19, P = 0.122; TR 6.63 ± 0.21 vs. 10.67 ± 1.28, P = 0.029)."
30285829
reach
"A few reports corroborate this, as TRAF6 (controlled by IL-1B, TLR2 and CYLD) was found to immortalize lymphocytes thereby sustaining the damage they can do without the check of CYLD mediated apoptosis [XREF_BIBR]."
25342597
eidos
"In the present study , we found that CYLD inhibition distinctly enhanced proliferation , reduced apoptosis , and increased the cell division of RA-FLSs and aggravated the activity of NF-kappaB in these cells , suggesting that CYLD is involved in RA-FLS hyperproliferation in RA ."
30285829
reach
"Therefore, inactivation of the CYLD1 protein may contribute to oncogenesis by enhancing the degradation of proteins that suppress cell proliferation or promote apoptosis."
15086550
reach
"In the present study, we found that CYLD inhibition distinctly enhanced proliferation, reduced apoptosis, and increased the cell division of RA-FLSs and aggravated the activity of NF-κB in these cells, suggesting that CYLD is involved in RA-FLS hyperproliferation in RA."
30285829
reach
"In addition to reduced proliferation, CYLD was shown to promote apoptosis in different cell types including HeLa XREF_BIBR or HaCaT cells XREF_BIBR by interfering with NF-kappaB signaling pathway."
21573132
reach
"Moreover, overexpression of CYLD increased TNF-alpha induced cell apoptosis in A549 cells."
27738385
reach
"CYLD also induces apoptosis and has been found to be underexpressed in several human cancers [XREF_BIBR]."
27923454
reach
"Loss of CYLD inhibits cellular apoptosis by activating NF-kappaB pathway [XREF_BIBR]."
26950276
reach
"Increased expression of CYLD in BT549 cells induced apoptosis, while its suppression by small interfering RNA inhibited cell death in BAF57 expressing BT549 cells."
16135788
reach
"In addition, CYLD overexpression markedly increased apoptosis of HCC827 and Calu-3 cells (XREF_FIG)."
29286108
reach
"Taken together, our data show that the presence of CYLD promotes brain pathology with increased neuroinflammation and hemorrhage as well as endothelial cell activation and apoptosis."
28203236
reach
"Song et al. showed that miR-301b was upregulated in TNBC specimens and cell lines, and inhibited the apoptosis induced by 5-FU by direct binding to 3′-UTR of CYLD lysine 63 deubiquitinase (CYLD) mRNA to activate NF-κB p65 [169]."
31766744
reach
"Firstly, we asked whether overexpression of CYLD-flag could induce cell apoptosis, which probably contributed to CYLD induced cell death."
27738385
reach
"Our previous research has demonstrated that adult T-cell leukemia/lymphoma (ATLL) had high level of CYLD phosphorylation, down-regulating CYLD phosphorylation could increase CYLD deubiquitinase activity and then promoted apoptosis in ATLL [XREF_BIBR]."
33827598
reach
"Consistently, CYLD expressing tumors had features of reduced cell proliferation and enhanced cell apoptosis as indicated by the decreased number of Ki-67-positive cells and the increased number of caspase-3-positive cells, respectively (XREF_FIG, XREF_SUPPLEMENTARY)."
22832488
reach
"Our findings underscore a putative mechanism whereby CYLD repression mediated and NF-kappaB transactivation dependent miR-19a regulatory feedback loop prevents cell apoptosis in response to OS microenvironment."
29050336
reach
"Flow cytometry and immunofluorescence microscopy reveal that CYLD increases the ability of noscapine to induce mitotic arrest and apoptosis."
25897332
reach
"In this study, loss-of-function and gain-of-function data show that depletion of CYLD compromises, while overexpression of CYLD potentiates PC12 cells apoptosis initiated by OS."
29050336
reach
"To corroborate the above findings, we examined the effects of CYLD and its mutants on noscapine induced apoptosis and mitotic arrest by flow cytometry."
25897332
reach
"Furthermore, we uncovered a dual function of CYLD in the pathogenesis of ECM : (i) CYLD impaired activation of PKC-theta and NF-kappaB in CD8 + T cells and (ii) CYLD promoted apoptosis of endothelial cells, thereby augmenting brain pathology and preventing survival during ECM."
28203236
reach
"These data indicate that CYLD is important for the ability of noscapine to induce apoptosis in ALL cells."
25897332
reach
"We then examined whether increasing the levels of CEP-1 and p53 could sensitize cyld-1 (tm3768) worms to DNA damage induced germ cell apoptosis in cyld-1 (tm3768) mutant worms carrying the gld-1 (op236) mutation."
27561390
reach
"These results indicated that CYLD increased apoptosis in NPC cells, whereas CYLD downregulation inhibited this process."
33149672
reach
"Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer."
22698400
reach
"CYLD Overexpression Promotes NPC Cell Apoptosis."
33149672
reach
"31 It seems that the germ cells are constantly exposed to NF-kappaB stimuli, but the magnitude of NF-kappaB activation is controlled by CYLD, thereby allowing the programmed cell death to occur."
19373246
reach
"Likewise, TNFR1, CYLD, and A20 silencing decreased the levels of cleaved CASP3/8 in trophozoite treated cells and reversed the pro apoptosis induction effect of trophozoites."
32525021
reach
"In conclusion, we demonstrated that CYLD downregulation promoted NPC cell proliferation and apoptosis resistance."
33149672
reach
"Moreover, CYLD reportedly promotes TNF-alpha-Induced apoptosis and programmed necrosis in human lung cancer cells."
33149672
reach
"Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells."
26545866
reach
"In line with a role of ubiquitylation in preserving RIPK1 in a survival mode, loss of CYLD and therefore sustained ubiquitylation was shown to block complex IIb formation and apoptosis induction [XREF_BIBR]."
27424290
reach
"Consistent with the immunofluorescence results, annexin V/PI staining based flow cytometry showed that CYLD and its C/S mutant, but not its DeltaCG1 mutant, promoted both early and late apoptosis induced by noscapine."
25897332
reach
"LEF1 mediated inhibition of CYLD expression is abolished upon selenite treatment to trigger apoptosis."
24577083
reach
"We found that CYLD overexpression increased both early and late apoptosis in CNE2 and HK1-EBV cells (XREF_FIG and XREF_FIG), whereas CYLD knockdown in HONE1 and 5-8F cells inhibited apoptosis relative to that observed in control cells."
33149672
reach
"Despite the previous report showing that CYLD can promote apoptosis by interfering with TNF-alpha signaling pathway XREF_BIBR, XREF_BIBR, we did not observe any differences in apoptotic rate under (1) non induced condition, (2) removal of serum, (3) when the cells were treated with TNF-alpha alone or (4) when treated with TNF-alpha together with cyclohexamide."
21573132
eidos
"SMARCE1 is located on chromosome 17q21.2 and is responsible for inducing apoptosis by stimulating expression of CYLD [ 65 ] ."
33801089
reach
"Taken together, these results indicate that selenite triggered upregulation of CYLD transcription induced RIP1 deubiquitination and apoptosis."
24577083