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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SOS1 binds SOS2, GRB2, and RasGEF. 2 / 2

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"The RasGEFs Sos1 and Sos2 are constitutively associated with the adaptor Grb2 and are recruited to the membrane where they have basal RasGEF activity via Grb2-LAT interactions (Grb2 binds LAT pY175, pY195, and pY235) ( xref )."

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"Once phosphorylated, LAT normally associates with two regulators of Ras activation: PLC-γ1, which activates the RasGEF RasGRP1 via DAG, and Grb2, which directly associates with the RasGEFs Sos1 and Sos2 ( xref )."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...