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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SRC bound to PTK2 activates RAC1. 2 / 2

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"The active FAK and Src complex stimulates Rac1 activity through phosphorylation of a number of mediators including the scaffolding protein p130Cas, paxillin, paxillin kinase linker, Pak interacting exchange factor-beta, and spleen tyrosine kinase."

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"Antroquinonol also suppresses FAK and Src complex formation, which subsequently inhibits Rac1 and Cdc42 activation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...