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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

NTRK1 bound to NGF activates ERK. 2 / 2

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"The binding of NGF to TrkA activates the PI3K-Akt (phosphatidylinositol 3-kinase-Akt) and Raf-MEK-ERK (Raf-MAPK and extracellular signal regulated kinase kinase-extracellular signal regulated kinase) signalling pathways, which promote the growth and survival of sympathetic neurons."

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"Binding of NGF to the TrkA receptor in PC12 cells activates the ERK family of MAPKs via two small GTPases, Ras and Rap1."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...