IndraLab

Statements

AKT increases the amount of MDM2. 14 / 17
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"Interestingly, romidepsin induced p21 involves Akt induced Mdm2 in a p53 independent manner by downregulating Akt and Mdm2 protein levels."
29515768
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"As expected, LY treatment (XREF_FIG C) or the knockdown of Akt (XREF_FIG D) decreased p-MDM2 expression and increased p53 expression compared with mock treatment."
26066464
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"Inhibition of AKT pathway reduces the cellular levels of p21 and MDM2, which in turns increases the expression of p53, resulting in cell death and cell cycle arrest [XREF_BIBR, XREF_BIBR]."
28903378
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"As mentioned above, activated PI3K and Akt pathway can strongly induce MDM2 transcription."
25704303
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"As shown on XREF_FIG, activation of AKT signaling by HRG effectively induced MDM2 protein expression, which was completely blocked by rapamycin in both MCF-7 and H1299 cells (XREF_FIG)."
23638184
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"Interestingly, the protein levels of HDM2 are not increased following H. pylori infection, but rather the levels of its phosphorylation by AKT kinase."
20547161
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"Blockage of PI3K and Akt downregulated the expression of p-Mdm2 and total Mdm2."
30176902
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"The use of DN-Akt and CA-Akt confirmed that Akt modulates the levels of MDM-2, p53, and p63 in RCC cells (XREF_FIG)."
18974107
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"Akt inhibition by LY294002 decreased Mdm2 expression, upregulated p53, and enhanced H. pylori induced growth inhibition of GES-1 cells."
25480405
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"Inhibition of Akt in cisplatin treated Dih10 cells with the pan-Akt inhibitor MK2206 reduced the amounts of phospho-S166 Mdm2 without affecting total Mdm2."
29894692
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"(2) Inhibition of AKT decreased the phosphorylation level of MDM2, and then increased the protein level of P53 which would accelerate death proceeding of tumor cells."
24147456
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"Our data suggest that stabilization of MDMX by Akt may be an alternative mechanism by which Akt up-regulates MDM2 protein levels and exerts its oncogenic effects on p53 in tumor cells."
18356162
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"Akt signaling enhances the expression of Mdm2 and downregulates p53 expression XREF_BIBR."
25144704
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"In addition, the blockage of PI3K and Akt by Ly294002 or knockdown of Akt by siRNA reduced the level of p-MDM2 and increased the level of p53."
26066464