IndraLab

Statements

EGFR binds ERBB2, ERBB3, and ERBB4. 19 / 19
| 19
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"HER2 can form a heterodimer with EGFR, HER3 or HER4 and is often over-expressed in breast cancer [ xref ]."
24036211
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"EGFR, HER3 and HER4 but not HER2 are associated with penile carcinogenesis."
21407808
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"HER3 forms active heterodimeric complexes with EGFR, HER2 and HER4."
29795445
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"Therefore, ligand-bound ErbB1, ErbB3, and ErbB4 and free ErbB2 can form homo- and/or heterodimers that consist of 1-1, 1-2, 2-3, 2-4, 3-4, 4-4, 1-3, and 1-4 receptors."
18004277
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"HER2 forms heterodimers with HER1, HER3, or HER4, generating signals that cause cell growth, overproliferation, and migration."
21925125
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"The total receptors HER1, HER2, HER3, and HER4 were significantly associated with standard prognostic factors in two instances."
22854050
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"The different family members interact with each other, i.e., HER3, which lacks intrinsic kinase activity, can form heterodimers with HER1, HER2, and HER4 [ xref ]."
33327495
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"The present results also revealed that the levels of ErbB1, ErbB2, ErbB3 and ErbB4 were associated with each other and were consistent with the results of Abd El-Rehim et al ( xref ) in breast cancer and that of Silva et al ( xref ) in head and neck squamous cell carcinomas."
29113229
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"Of the ErbBs, both ErbB3 and ErbB4 bind the NRGs as homodimers, but ErbB1 and ErbB2 can also form heterodimers with ErbB3 or ErbB4 ( xref )."
31454079
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"Afatinib covalently binds to all homodimers and heterodimers formed by EGFR, HER2, ErbB3 and ErbB4, thereby inhibiting tyrosine kinase autophosphorylation and downregulating ErbB signalling [ xref – xref ]."
29540977
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"Overexpression of EGFR, erbB2, erbB3 or erbB4 alone was not significantly associated with a shortened survival."
12008194
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"Pertuzumab, another monoclonal antibody, is a HER2 dimerization inhibitor that binds to a different epitope on HER2 than trastuzumab and inhibits HER2 dimer formation with HER1, HER3, and HER4, which is required for HER2 to engender a signal ( xref )."
27713847
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"However, it is unclear how erbB2 specifically associates with erbB1, erbB3, or erbB4 in the presence of particular ligands."
10973996
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"Given its inability for ligand binding, it is obligatory for HER2 to form a heterodimer with EGFR, HER3 or HER4 to generate high-affinity complexes with different ligands. xref , xref "
31849462
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"This included several genes commonly associated with cancer pathogenesis such as the EGF receptor family members ERBB2, ERBB3, and ERBB4 , the purported melanoma oncogenes MITF and NEDD9 , and several markers of pluripotency, including NES, SOX2, and NANOG ( xref )."
22681858
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"Studies of full-length receptor phosphorylation [ xref ] and of interactions between chimeric receptors with an intracellular reporter domain [ xref ] are also consistent with a model in which ErbB2 forms hetero-oligomers with ligand-bound EGFR, ErbB3 or ErbB4."
19038249
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"Afatinib is an irreversible ErbB-family inhibitor that, by contrast with EGFR tyrosine kinase inhibitors, selectively blocks signalling from all homodimers and heterodimers formed by EGFR, HER2, HER3,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26156651
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"Afatinib is a TKI that selectively blocks the signaling of homodimers and heterodimers formed by EGFR, HER2, HER3, and HER4 in OS cell lines[ xref ]."
36176756
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"For instance, EGFR (erbB-1) will interact with erbB-2 and erbB-3 but not erbB-4, but erbB-4 will pair with erbB-2."
10404636