IndraLab

Statements

CTNNB1 binds CTNNB1 and GNAS. 4 / 4
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"These Western studies also highlighted the presence of a gene-expression subclass associated with somatic mutations in exon 3 in CTNNB1 gene and nuclear accumulation of beta-catenin protein."
20175032
sparser
"Classically, CTNNB1 exon 3 mutations are associated with decreased degradation of β-catenin, accumulation of β-catenin protein in the cytoplasm, and then translocation of β-catenin protein to the nucleus."
29795437
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"2 This study demonstrates that aberrant nuclear localization of β-catenin is significantly associated with CTNNB1 exon 3 mutations."
11238046
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"Although cytoplasmic/nuclear accumulation of β-catenin is frequently found in the malignant uterine cervix, this increase in β-catenin is not associated with a mutation in exon 3 of CTNNB1 [ xref ]."
20482749