IndraLab

Statements

MTOR leads to the phosphorylation of RPS6KB1 on S447. 4 / 4
1 | 1 2
phosphoelm
No evidence text available
11914378
sparser
"PHD3 knockdown also increased the phosphorylation of JNK at Thr 183 and Tyr 185 under basal and TNF-α-stimulated conditions (Fig.  xref ) but reduced mTOR complex 1-dependent phosphorylation of p70 S6 kinase at Thr 389 , Thr 421 , and Ser 424 (ref. xref ) under insulin stimulation (Supplementary Fig.  xref ), consistent with impaired insulin signalling."
30250231
sparser
"Ethanol inhibition of p70S6K phosphorylation could have been mediated by inhibition of Akt, mTOR, or both, as the multiplex-ELISA detected pTpS421/424 -p70S6K; the T421 and S424 residues on p70S6K are phosphorylated by Akt and mTOR ( xref )."
21790669
reach
"Inhibition of mTOR with rapamycin blocked the Thr 389 but not the Thr-421 and Ser-424 phosphorylation of S6K1."
11940578