IndraLab
Statements
"<span class="match term0">USP10</span>, a primary cytoplasmic DUB, acts as an oncogene or a tumor suppressor by regulating various protein substrates, including <span class="match term1">FLT3</span>, p53, AMPK, PTEN, etc."
reach
"However, in acute myeloid leukemia (AML) patients with activating mutations in FMS‐like tyrosine kinase 3 (FLT3), USP10 deubiquitinates and stabilizes FLT3 by removing the proteolytic polyubiquitin chains and preventing FLT3 degradation, to aggravate tumor progress (Weisberg et al., 2017)."