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NGF increases the amount of NTRK1. 46 / 47
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"NGF mediated neuronal differentiation was observed solely in trkA expressing B104 derived clones and was characterized by reduced cell growth, activation of NGF regulated genes, and downregulation of the endogenous low-affinity NGF receptor gene (gp75NGFR)."
7761093
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"NGF synthesis in the peripheral tissue and TrkA expression in the sensory neuronal soma do not begin until the fibers reach their peripheral targets."
25484893
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"We show that TrkA expression is indeed induced by NGF in PC12 cells with a time course that paralleled the increase in Ras, pERK and pAKT activities as well as Rasa2 expression (XREF_FIG)."
22206868
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"Neonatal intraventricular administration of NGF increases the expression of Chat and Ntrk1, the gene that encodes the high-affinity NGF receptor TrkA, whereas administration of anti-NGF decreases the expression of both genes."
20554873
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"Beta-NGF gene therapy significantly increased TrkA expression in the DRG."
31535665
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"Administration of NGF eyedrops restored TrkA levels in the retina, and protected RGCs from degeneration without influencing VEGF levels."
24030532
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"NGF, but not IL-1 beta, TNF-alpha and CCK-8, enhances the expression of TrkA in isolated synovial cells."
14611111
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"The results showed that LMQWD could significantly reduce the arrhythmia susceptibility and the degree of fibrosis in myocardial tissues, decrease the levels of TH, ChAT, and GAP-43 in the myocardium and ganglion, increase NGF, inhibit the expression of TRPM7, and up-regulate p-AMPK/AMPK and p-TrkA/TrkA levels."
37282948
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"Finally, we observed that NGF multiple stimulations progressively increased TrkA expression in HASMC, which was associated with an increase in NGF and TrkA dependent proliferation."
18573284
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"In vitro studies using human synovial fibroblasts demonstrated that the stimulation by IL-1β increased NGF levels and the addition of NGF increased TrkA levels [23]."
33507995
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"NGF stimulated a 2.7-fold increase in HIF-1alpha transcriptional activity in TA25 cells expressing high levels of TrkA, but BDNF did not (XREF_FIG)."
21145972
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"Exogenous NGF slightly increased pTrkA levels, and these effects were inhibited with the addition of the anti-TrkA-neutralizing antibody (XREF_SUPPLEMENTARY)."
28557340
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"Recent evidence indicates that NGF upregulates the expression of both trk and p75 in responsive neurons including rat dorsal root ganglion (DRG) neurons."
8838569
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"Some other critical factors including dosage of inhibitor, NGF inducing TrkA expression, 37 and activation of p75 receptor might affect the NGF induced process."
24714423
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"Decades of research have demonstrated that NGF directly activates and sensitizes TrkA-expressing sensory neurons and that NGF activation of TrkA could play a key role in the sensitization of TrkA-expressing nociceptors to mechanical, chemical and thermal stimuli (Levi-Montalcini, 1987; Lewin & Mendell, 1993; Petruska & Mendell, 2004)."
24494689
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"In line with this, DHEA or NGF up-regulated, whereas testosterone down-regulated, the expression of TrkA receptor."
23696568
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"[Neuronal differentiation and TrkA expression of neuroblastoma induced by the combination treatment of interferon-gamma and NGF]."
15144710
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"NGF induced phosphorylation of the trkA receptor, activated a cascade of cellular intermediaries such as phospholipase C gamma 1 and ERK proteins, and stimulated c-fos gene transcription in all trkA expressing clones."
7761093
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"Exogenous NGF Upregulates the Expression of TrkA, p75, and FSHR of CUMS Rat Ovarian Tissue in vitro."
32685448
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"In this study, we showed that NGF strongly upregulated the protein level of tropomyosin related kinase A (TrkA) in TrkA inducible SK-N-MC cancer cells, resulting in increases in various TrkA dependent cellular processes, including the phosphorylation of c-Jun N-terminal kinase (JNK) and caspase-8 cleavage."
27229480
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"K-252a (a inhibitor of Trk tyrosine kinase activity) induces a dose dependent inhibition of the NGF induced growth stimulatory effect."
11205897
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"Both NGF and DHEA significantly increased pro survival TrkA receptor levels in the time frame studied, i.e. from 12 to 48 h (n = 5, p < 0.01) (XREF_SUPPLEMENTARY)."
21541365
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"The increase in HIF-1alpha transcriptional activity may also be regulated by the level of TrkA expression, since NGF stimulated a 2.7-fold increase in TA25 cells expressing high levels of TrkA (TET-) compared to a 2-fold increase in TA25 cells expressing low levels of TrkA (TET+) (XREF_FIG)."
21145972
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"The TrkA expressing amacrine cells are not supported by NGF and subsequently die."
11171331
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"We found that II-1beta, but not NGF, promotes fibroblasts ' survival and that NGF stimulates trkA receptor expression, down regulates TFG-alpha, and has no effect on TNF-beta immunoreactivity."
16389726
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"Furthermore, induction of trk expression by NGF suggests that neurotrophin mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors."
1524827
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"Exogenous NGF delivered to DRG for 2 weeks partially reversed the reduction of TrkA expression as well as atrophy of TrkA immunoreactive neurons."
11000445
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"A possibly related phenomenon is that, in vitro, NT-3 stimulates predominantly branching of TrkC expressing neurons, whereas NGF stimulates predominantly elongation of TrkA expressing neurons [XREF_BIBR]."
24028951
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"Our results suggest that NGF supports the survival of TrkA expressing avian horizontal cells in an autocrine mode of action in the retina of E10-E12 chicks."
11171331
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"Antioxidant treatments increase NGF-dependent activation of ERK and CREB and rescue TrkA expression and cognitive and cholinergic functions in rodent models of neurodegenerative disease [117,118]."
34440751
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"However, another study has found that NGF does not promote survival of human lung fibroblasts in vitro, but does stimulate TrkA expression, without affecting cytokine signaling, thus indicating that NGF released by fibroblasts (e.g., during inflammation) is not associated with increased proinflammatory factors [XREF_BIBR]."
20524922
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"Here we demonstrate that TrkA is expressed in primary cultures of hippocampal neurons and is activated by NGF within 10 min of exposure."
12453482
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"PC12 cell extracts were analysed by Western blot to detect the endogenous levels of the receptor TrkA activated by NGF (i.e., phosphorylated at tyrosine 490), confirming that both NGF and MNP-NGF induce NGF receptor phosphorylation."
29098325
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"In contrast, in aged rats tested immediately after termination of treatment, NGF induction of TrkA expression may result in an increased signal transduction activated by TrkA."
12009509
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"The expression of TrkA, p75, and FSHR in CUMS ovarian tissue was upregulated by exogenous NGF in vitro."
32685448
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"TrkA expression is stimulated by NGF itself in basal forebrain in rats suggesting that upregulation of NGF may result in amplification of pain sensation with hyperesthesia and allodynia."
23973134
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"As NGF, primarily secreted by keratinocytes at the epidermis, promotes axonal innervation of the TrkA-expressing DRG neurons at the footpad (Huang and Reichardt, 2001), and we demonstrated that these vpr/RAG1 mice have less epidermal innervation, we went on to investigate if chronic Vpr exposure affected NGF expression at the footpad of these immunodeficient mice."
23912036
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"NGF can upregulate the expressions of p75 and trkA mRNA in asthmatic rats, and then may promote their role in the airway neuronal inflammation in asthma."
16708804
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"First of all, NGF enhances the expression of its own receptor TrkA, as experimentally demonstrated in basal forebrain neurons from fetal rats.22 Moreover, NGF has been shown to enhance the expression of substance P and CGRP in the neurons of C fibers, thus sensitizing neurons to hyperalgesia."
23028238
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"Rasa2 and TrkA expression is upregulated by NGF stimulation."
22206868
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"For example, the expression of TrkA and P75 receptors in different stages of follicular development and different types of ovarian tissue cells (oocyte, granulosa cell, or follicular membrane cell), the expression of downstream genes caused by the NGF and TrkA signaling pathway, and the dose dependent relationship between POI and NGF expression."
32685448
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"Our results showed that endogenous NGF can induce TrkA autophosphorylation, and exogenous NGF can further enhance the phosphorylation level of TrkA."
27835587
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"Application of the Trk antagonist K252a blocks the NGF mediated potentiation and TrkA is expressed by sympathetic neurons, but not myocytes, suggesting a presynaptic role for this signaling."
19748836
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"Functional nerve growth factor (NGF) responsiveness was investigated in human neuroblastoma (NB) cell lines in vitro and retinoic acid (RA) was found to transcriptionally enhance expression of the trkA, but not the trkB gene in GOTO cells, while the reverse was found in HTLA230 NB cells."
9811468
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"Both 5 and 50 ng of NGF and day failed to induce an effect on transmembrane protein tyrosine kinase trkA mRNA levels, but injections of 750 or 1500 ng/day of NGF up-regulated trkA mRNA expression to approximately 2-fold of control."
8632763
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"GDNF and NGF also enhanced the expression of their respective functional receptors Ret and TrkA on the DRG neurons."
19523996