IndraLab

Statements

IL1B decreases the amount of IRS1. 12 / 13
| 12
reach
"IL1beta down-regulates insulin receptor substrate 1 expression, inhibiting insulin induced AKT phosphorylation and glucose uptake in adipocytes [XREF_BIBR]."
29735414
reach
"These findings are in agreement with a previous report by Jager et al., in which IL-1beta decreased IRS-1 protein expression and inhibited IRS-1 and Akt signaling in adipocytes, leading to decreased insulin stimulated glucose transport."
23891856
reach
"IL-1beta may suppress IRS-1 expression ERK-dependently during transcription and ERK-independently during post-transcription, which may damage insulin signaling [XREF_BIBR]."
22953221
reach
"Similarly, IL-1β has been shown to inhibit IRS-1 expression, leading to decreased insulin-induced glucose transport in adipocytes [28]."
30116147
reach
"Similar to TNFα, IL-1β was shown to reduce IRS1 expression at both transcriptional and posttranscriptional levels (31), while the IL-1β-mediated deterioration of insulin signaling is largely due to the IL-6 production and suppressor of cytokine signaling 3 (SOCS3) induction in 3T3-L1 adipocytes (32)."
34869524
reach
"Previous studies, mostly using murine 3T3-L1 adipocytes, have shown that IL-1beta at a very high dose (20 ng/ml) decreased protein expression of IRS-1 and GLUT4 transcripts, and prolonged treatment blunted insulin induced phosphorylation of IRS-1 and Akt."
24918199
reach
"These results demonstrate that IL-1beta reduces IRS-1 expression at a transcriptional level through a mechanism that is ERK dependent and at a posttranscriptional level independently of ERK activation."
17038556
reach
"Similarly, IL-1β was shown to reduce IRS1 expression at both transcriptional and posttranscriptional levels (104), and the lack of IL-1β receptor improves glucose homeostasis and protects mice from developing adipose tissue inflammation after high-fat diet (105)."
34869524
reach
"It has been demonstrated that, in insulin targeted cells, IL-1beta reduces the IRS-1 expression through an ERK dependent mechanism at the transcriptional level and an ERK independent mechanism at the post-transcriptional level [XREF_BIBR]."
33758645
reach
"IL1beta down-regulates insulin receptor substrate 1 expression, inhibiting insulin induced AKT phosphorylation and glucose uptake in adipocytes [59]."
29735414
reach
"Hence IL-1beta promotes the inhibitory serine phosphorylation, decreases IRS-1 total protein expression, and inhibits insulin stimulated tyrosine phosphorylation of IRS-1."
23891856
reach
"The role of IL-1Ra is emerging in the development of type 2 diabetes mellitus, as IL-1 beta has been reported to inhibit insulin receptor substrate-1 expression mainly through messenger RNA, the amoun[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20178882