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BDNF activates ERK. 344 / 346
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"Moreover, we find that TrkB axonal transport mediated by JIP3 could regulate BDNF-induced Erk activation and axonal filopodia formation."

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"BDNF effectively prevented PCP induced inhibition of the ERK and PI-3K and Akt pathways and suppressed GSK-3beta activation."

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"We found that 2 h Aβ (10 μM) exposure could inhibit both BDNF-induced Akt and Erk1/2 activation ( Figs."

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"Alternatively, the brain derived neurotrophic factor (BDNF)-induced activation of the neurotrophic receptor tyrosine kinase 2 (TrkB) can trigger the initiation of the MEK and ERK signaling pathway, also driving protein translation via multiple mechanisms including activation of mTORC1."

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"First, consistent with the Arc up-regulation profile, ERK was robustly activated by sub-nanomolar BDNF (XREF_FIG)."

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"We further suggest that CaM KII/IV activity is not required for BDNF induced ERK activation."

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"TCN-201 infusion into the prelimbic cortex inhibited the BDNF-mediated increase in pERK and pGluN2A whereas Ro-25-6981 infusion into the prelimbic cortex blocked BDNF-induced elevation of pERK and pGluN2B, indicating that both GluN2A- and GluN2B-containing NMDA receptors underlie BDNF-induced ERK activation."

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"Then, the ERK pathway, activated by increased endogenous BDNF in brain injuries, could stimulate downstream kinases and transcription factors for neuroprotection."

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"In contrast, intrahippocampal administration of recombinant human BDNF increased ERK1/2 and CREB activation and facilitated LTM."

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"Experimental studies have revealed that dexmedetomidine can increase BDNF expression by directly acting on the α2A receptor and then modulating the ERK1/2 pathway, and BDNF can in turn promote the expression of Bcl-2 and BCL-XL by activating the PI3K/Akt signaling pathway and MAPK pathway and thus suppressing the p38 and c-Jun N-terminal kinase (JNK) pathways, which eventually leads to a decrease in neuronal apoptosis (Bell et al., 2014; Li Z.C."

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"BDNF activation of ERK1/2 appears to involve TrkB as previously shown using TrkB siRNA xref ."

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"To enhance Dicer function, BDNF activates the MAPK and ERK signaling pathway through the TRKB receptors."

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"From these observations, we concluded that there is a paracrine signaling network in the DG whereby prolonged Fas activation in immature neurons induces the release of BDNF, which then activates ERK in neural stem cells."

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"Our TrkB knockdown experiments in this study demonstrated a critical role of TrkB in BDNF-induced Pyk2 and ERK activations and the invasion of A549 cells."

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"In nonraft regions, however, both Erks and Akt were activated by BDNF application (XREF_FIG)."

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"P021 treatment during early development prevented cognitive impairment and increased expressions of pCREB and BDNF that activated downstream various signaling cascades such as PLC and PKC, MEK and ERK and PI3K and Akt, and ameliorated synaptic protein deficit in 4-month-old 3xTg-AD mice."

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"In addition, ERK1/2 activation by BDNF is expected to be a STEP 61 -independent process, as STEP 61 normally determines the duration of ERK1/2 activation by its dephosphorylation."

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"As shown in Figure 3B, the expressed NR2B- and RasGRF1-BD peptides had no effect on depolarization- or BDNF induced ERK activation."

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"Here we show that clinically relevant concentrations of ethanol inhibit axon outgrowth and the activation of the SFK-Cas-ERK1/2 signaling pathway by netrin-1, GDNF, and L1, but do not disrupt BDNF induced axon outgrowth or ERK1/2 activation."

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"However the activation of ERK by BDNF treatment was greatly reduced."

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"The WAVE1 complex is required for BDNF-TrkB endocytosis and BDNF induced acute ERK activation."

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"Therefore, this study tested whether BDNF infusion increases ERK activation in vivo and improves neurological recovery after normothermic cardiac arrest in rats."

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"In contrast, expression of a kinase dead mutant of Fyn in oligodendrocytes significantly inhibited BDNF induced activation of Erk1/2 and abrogated the promyelinating effect of BDNF."

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"The authors showed that suppressed Retrolinkin expression prevents TrkB internalisation under BDNF stimulation and activation of ERK, resulting in reduced dendrite growth of CNS neurons."

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"Importantly, ethanol did not inhibit axon outgrowth mediated by BDNF, a ligand that activates ERK1/2 without first activating SFK or Cas."

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"The intracellular activation of ERK by BDNF might proceed by way of signaling through the BDNF receptor tropomyosin related kinase B (TrkB)."

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"In addition, the increased Pyk2 and ERK activities induced by BDNF were significantly inhibited by blocking TrkB expression, so was the invasion of A549 cells."

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"The L1 neural cell adhesion molecule, netrin1, and GDNF promote axon outgrowth by stimulating both Src family kinase (SFK) and MAP kinases and ERK1 and 2, whereas BDNF induces axon outgrowth only by activating ERK1/2."

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"ERK1/2 activation mediated by BDNF, promotes cell survival in the brain in cerebellar granule neurons (Bonni et al., 1999; Hetman and Gozdz, 2004)."

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"To directly test this hypothesis, we examined the effect of calpain inhibition on BDNF-induced ERK1/2 activation in acute hippocampal slices."

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"In a remarkable model recently discovered by Park et al. [ xref ], the dopamine D1 receptor agonist or brain-derived neurotrophic factor (BDNF) activated ERK1/2, leading to inducible and reversible phosphorylation of mGluR5 at S1126 in striatal neurons as detected by a phospho- and site-specific antibody ( xref )."

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"BDNF has been shown in other systems to activate ERK [44] and a role of released BDNF in the activation of ERK in the RVM seems likely."

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"Control experiments showed that BDNF and PDGF activate the ERK and Akt signaling pathways under the experimental conditions used, as determined by Western blotting with antibodies against pAkt and pERK1/2 (XREF_FIG)."

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"CPE is also known as NF-alpha1 as it induces ERK and Akt signalling, similar to classic trophic factors, such as BDNF or nerve growth factor."

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"For instance, we should continue to dissect the interaction between BDNF mediated ERK signaling and Ca 2+ / calmodulin mediated signaling."

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"BDNF normally activates ERK and Akt in motor neurons thus it is somewhat surprising that inhibition of spinal MEK (the kinase that activates ERK) abolishes pLTF (Hoffman and Mitchell, unpublished), whereas inhibition of spinal PI3 kinase (which leads to Akt activation) does not (Hoffman and Mitchell, unpublished)."

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"Taken together, improved BDNF and TrkB, up- and down-stream signaling pathways were involved in antidepressant like effects of SLB effects.To check whether the activation ERK and CREB was mediated by [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"A functional CRE site in the PGC-1α co-activator gene, which is activated by BDNF-induced activation of ERKs and CREB, mediates PGC-1α expression and mitochondrial biogenesis."

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"These observations indicate that the Pol1 mediated nucleolar transcription regulates neurite outgrowth and serves as a major pro neuritic effector of the BDNF activated ERK1/2 pathway."

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"We also examined the expression level of brain derived neurotrophic factor (BDNF), which could activate the ERK pathway [XREF_BIBR]."

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"In turn, BDNF feeds back to further activate the Raf -> ERK pathway."

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"These results demonstrated that NMDA-, but not BDNF induced ERK activation depends on PI3K and PLC activity."

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"Another finding showed that 3,6’-Disinapoyl sucrose-triggered regulation of BDNF gene expression was associated with CREB-dependent BDNF transcription and upstream molecular activation of CaMKII and ERK1/2 in SH-SY5Y cells [ xref ]."

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"The results showed that the BDNF activated the PI3K and Akt and MEK1 and ERK pathway in the time dependent manner."

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"Conclusion : BDNF promotes the differentiation of iPSCs by activating Wnt and beta-catenin and ERK and MAPK signal pathway, there should be cross-talk between the two signal pathways, and c-fos and c-jun may be common nuclear transcription factors."

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"For example, BDNF prevents nitrous oxide (NO)-induced cell death in hippocampal neurons, and these effects are mediated via BDNF induced activation of extracellular signal regulated kinase (ERK) 1/2 and phosphatidylinositol-3-kinase (PI3K)/Akt pathways."

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"In addition, ERK1/2 activation by BDNF is expected to be a STEP 61 -independent process, as STEP 61 normally determines the duration of ERK1/2 activation by its dephosphorylation."

sparser
"Therefore, KSR1 is specifically involved in antigenotoxic activation of ERK1/2 by BDNF."

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"In addition, pairing induced synaptic potentiation was blocked by ERK inhibitors, suggesting that BDNF activates the MAPK and ERK cascade, which may lead to transcriptional regulation and new protein synthesis in the postsynaptic neuron."

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"Furthermore, we investigated whether brain derived neurotrophic factor (BDNF)-mediated activation of extracellular signal regulated kinase (ERK) 1/2 signaling pathway is involved in the neuroprotection induced by EA at acupoints."

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"Here we report that in this system, BDNF increased KSR1 association with activated ERK1/2, whereas KSR1 knockdown with a short hairpin (sh) RNA reduced BDNF mediated activation of ERK1/2 and protection against a DNA damaging drug, camptothecin (CPT)."

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"Recently, the D1 receptor agonist or brain-derived neurotrophic factor activated ERK1/2 and induced U0126-sensitive mGluR5-S1126, although not mGluR5-T1123, phosphorylation in striatal neurons, which facilitated Pin1-mGluR5 interactions and thereby potentiated mGluR5 activity in triggering NMDA receptor-mediated currents [ xref ]."

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"This study elucidates a mechanism whereby BDNF and TrkB (tropomyosin receptor kinase B) activates ERK regulated CREB phosphorylation in the dmPFC to counteract the neuroadaptations induced by cocaine SA and subsequent relapse to cocaine seeking."

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"Although BDNF robustly activated ERK1/2, ethanol had no effect on BDNF activation of ERK1/2 (XREF_FIG)."

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"We found that acute BDNF treatment (30 min) increases AMPAR surface expression in an ERK dependent manner, while long-term BDNF treatment (24 h) decreases AMPAR surface expression."

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"In vitro, Nogo-66 attenuated BDNF elicited activation of both the AKT-p70S6K and erk1/2 pathways."

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"However, comparative studies of growth factor mediated survival signaling in hippocampal cell culture show IGF-1 strongly induces AKT though weakly induces ERK, while BDNF strongly induces ERK and only weakly induces AKT XREF_BIBR."

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"ERK1/2 is activated by BDNF and in turn, induces an increase in the neurotrophin levels, through CREB activation, suggesting a relationship between ERK1/2 activation and optimal levels of BDNF in the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Finally, Erk activation by either depolarization or BDNF treatment was also normal in cultured neurons from Sos2 knockout mice."

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"Kal7 binds directly to the GluN2B subunit of GluN receptors, placing it where it could be cleaved by mu-calpain activated by Ca 2+ entering via this ion channel or by m-calpain activated by BDNF stimulation of Erk 21."

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"The NMDA receptor antagonist 2-amino-5-phosphonovalerate did not effect basal pERK or inhibit BDNF stimulation of ERK, suggesting that NMDA receptors do not modulate BDNF stimulation of ERK in short-term cultures."

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"Differential kinetics of ERK1/2 activation has also been reported; however, a continuous exposure to BDNF over 2-6 h was required for a persistent phosphorylation of ERK1/2 for cortical neurons in culture XREF_BIBR, XREF_BIBR, while BDNF elicited a rapid and transient activation of ERK1/2 in hippocampal slices XREF_BIBR."

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"In these analyses, we investigated the transcription factor CREB as a common target in pathways induced by both Rolipram and BDNF XREF_BIBR, XREF_BIBR and the protein kinase ERK, which is a major effector within the BDNF signaling pathway XREF_BIBR."

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"Retrolinkin and endophilin A1 are required for BDNF induced dendrite outgrowth and acute activation of ERK."

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"Hence, KSR1 is critical for the antiapoptotic activation of ERK1/2 by BDNF or cAMP and PKA signaling."

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"Rusanescu et al. ( xref ) suggested that BDNF-induced activation of Ras, Akt and ERK is regulated by increased cross-talk between Shp2 and TrkB receptor."

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"In this same model, elevated BDNF levels parallel activation of ERK, and levels of both BDNF and active ERK are increased by hypothermia [XREF_BIBR]."

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"Additionally, BDNF initiates ERK-dependent activation of nuclear transcription factor CREB via receptor TrkB [47]."
| PMC

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"Studies have shown that brain derived neurotrophic factor (BDNF) is an activator of ERK1/2, and that its upregulation may evoke excessive neuronal excitability and trigger mossy fiber sprouting."

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"One of the major functions of BDNF mediated ERK1/2 and PI 3-K/Akt signaling is to regulate proteins involved in cell survival."

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"Pre-treatment with the Mek inhibitor U0126, blocks BDNF mediated activation of Erk and CREB, and confirms that CREB is downstream of TrkB and the Mek and Erk pathways."

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"Primary DRG cultures chronically treated with TNF-alpha showed significant enhancement of mRNA and protein levels of BDNF and trkB receptor, BDNF release and trkB-induced phospho-ERK1/2 signal."

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"Ephrin-A5 suppressed BDNF induced ERK activity and might sequester P-ERK in the cytoplasm."

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"Eliminating calcium influx by removal of calcium from the incubation buffer had no impact on BDNF signaling to ERK1/2, nor did it prevent the inhibiting effect of epinephrine on BDNF-induced ERK1/2 activation."

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"Indeed, the GSI mediated effect on BDNF induced Erk1/2 activation and nuclear translocation of pCREB are evidence for this possibility."

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"Indeed, immunoblotting analysis revealed that, similar to retrolinkin knockdown, shRNA mediated knockdown of WAVE1 impaired acute activation of ERK in neurons treated with BDNF, whereas neither prolonged activation of ERK nor the kinetics of Akt activation was affected (XREF_FIG)."

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"In fact, we found that BDNF treatment more potently activates ERKs when the amount of SCOP is higher in the hippocampal rafts in cultured neurons (XREF_FIG)."

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"The intracellular activation of ERK by BDNF might proceed by way of signaling through the BDNF receptor tropomyosin-related kinase B (TrkB)."

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"Brain derived neurotrophic factor activation of extracellular signal regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal regulated kinase shutoff pathway."

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"Brain Derived Neurotrophic Factor (BDNF) was used to stimulate ERK in hippocampal slices prepared from PN5 pups and activation and cellular localization was determined with immunofluorescence combined with confocal microscopy."

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"Our results demonstrated that BDNF activated NFkappaB and JNK pathways, but not other MAP kinases (p38 or Erk1/2) or AKT signaling."

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"Bilirubin inhibited NGF and BDNF activation of ERK1/2 in PC12 and primary rat CGN ( xref )."

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"Both cAMP and BDNF can activate mitogen activated protein kinase (MAPK and ERK), which also plays a role in LTP."

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"Accumulating evidence shows that microglia in the spinal cord plays a key role in the origin of chronic pain by releasing pro-inflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and brain-derived neurotrophic factor (BDNF).4 In astrocytes, IL-1β treatment activated ERK and released MMP-2."

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"However, the underlying mechanism seems to be complicated, as BDNF can activate multiple signaling pathways (PI3K and AKT, MEK and ERK, PLCgamma-PKC and PLCgamma-CaMKII, etc.) to regulate certain transcription factors (CREB and NF-kappaB, etc.) by inducing TrkB receptor phosphorylation [XREF_BIBR], but the exact functional mechanism needs to be revealed in the future."
| PMC

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"Even though the ERK pathway was also activated in the spinal cord by BDNF during colitis [XREF_BIBR], the activation of this pathway did not lead to NR1 phosphorylation at Ser 896."

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"We found that BDNF activation of ERK and PI3K was mutually independent."

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"BDNF did not activate SFK or Cas, and PP2 did not inhibit BDNF activation of ERK1/2 or its induction of axon outgrowth."

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"Concisely, Cynomorium songaricum Rupr exhibited potential therapeutic effect on Neuroprotection of ovariectomized rats, and its effect was possibly exerted by p-CREB/BDNF mediated down regulation of ERK/p38MAPK."

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"As shown in xref , this is associated with sustained activation of TrkB and ERK by BDNF."

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"These results indicate that VPA could regulate NMDA receptor-ERK signaling in SD rats, preventing the SD induced decrease of the expression of NR2B subunit and the activation of ERK signaling mediators such as ERK, CREB, BCL2, and BDNF."

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"Further studies demonstrate that ethanol exposure blocks BDNF signaling in cultured CGC which is evident by a diminished response to BDNF stimulated activation of ERK and PI3K."

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"Our findings identify a requirement of BDNF-induced acute ERK activation for dendrite development and provide novel insights into the molecular mechanisms for membrane trafficking to regulate the specificity of RTK-mediated signal transduction."

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"As shown in Figure 3B , the expressed NR2B- and RasGRF1-BD peptides had no effect on depolarization- or BDNF-induced ERK activation."

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"In brain, BDNF can co-localize with TrkB receptor, triggering ERK activation and counter-regulate the expressions of apoptotic factors such as caspase-3 and Bax and the anti-apoptotic factor Bcl-2 to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We decided to study signaling by the neurotrophin BDNF, as activation of the BDNF receptor TrkB strongly activates ERK1/2 signaling, but evokes modest Ca 2+ mobilization compared with action potential bursting."

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"The BDNF activates the PI-3K/Akt and MAPK/ERK pathways through binding to its tyrosine kinase TrkB receptor thereby activating downstream molecules that can promote neurogenesis and cell survival [105]."

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"So it is not surprising that BDNF can activate ERK."

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"Furthermore, BDNF-dependent ERK activation is not altered in primary hippocampal neurons isolated from Rit −/− mice [ xref ]."

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"Ethanol exposure also diminishes BDNF stimulation of ERK signaling in cerebellar granule cell (Ohrtman et al., 2006)."

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"In cultured rat cortical neurons, BDNF activates ERK1/2 to enhance neuronal survival by suppressing DNA damage- or trophic deprivation induced apoptosis."

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"Thus, different treatment strategies that target different protein changes depending on the phase of addiction may be required to treat addiction.Because glutamatergic neuronal activity enhances the d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Interestingly, myelin pre-treatment of primary neurons attenuates BDNF elicited activation of erk1/2 (XREF_FIG)."

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"We have observed that BDNF activated the extracellular regulated kinase (ERK) mitogen activated protein (MAP) kinase and the phosphatidylinositol (PI) 3-kinase pathways."

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"In cultures of cortical neurons, BDNF activates ERK1/2 via phosphoinositide dependent kinase-1, and the decrease of BDNF causes a reduction in the levels of ERK1/2 phosphorylation (Kharebava et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Raf-1 and ERK phosphorylation and p35 expression levels increased significantly in cells treated with both NIM and BDNF."

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"In contrast, acute activation of ERK1/2 was impaired, whereas levels of phosphorylated ERK1/2 (pERK1/2) at 60 min after BDNF addition were not affected in cells depleted of either protein ( xref ), indicating that they selectively regulate BDNF-induced acute ERK1/2 activation."

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"Although, in some systems PDK1 may be upstream of the MKK1-ERK1/2 pathway, in cortical neurons, TCPK did not affect BDNF mediated activation of ERK1/2 but reduced the constitutive autophosphorylation of PDK1 at Ser241 (XREF_SUPPLEMENTARY)."

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"The canonical ERK pathway (XREF_FIG) is initiated by brain derived neurotrophic factor (BDNF) binding to a receptor tyrosine kinase (TrkB) [XREF_BIBR], which, through several intermediary molecules, recruits a guanosine exchange factor (GEF) that activates a monomeric GTP binding protein called Ras [XREF_BIBR]."

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"Our findings identify a requirement of BDNF induced acute ERK activation for dendrite development and provide novel insights into the molecular mechanisms for membrane trafficking to regulate the specificity of RTK mediated signal transduction."

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"Whereas some studies also showed that BDNF stimulates ERK pathway against hypoxia-ischemia XREF_BIBR."

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"Ethanol was reported to inhibit BDNF activation of ERK1/2 in CGNs; however, these experiments used CGNs after three days in vitro, in contrast to one day in our experiments."

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"In addition, we here show that ephrin-A5 counteracted BDNF induced ERK activity and reduced therefore P-ERK levels in the nucleus (XREF_FIG and XREF_FIG)."

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"The findings support a mechanism by which BDNF and TrkB activates ERK regulated CREB phosphorylation in the dmPFC to counteract the effects of cocaine SA and subsequent relapse to cocaine seeking."

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"Retrolinkin directly interacts with endophilin A1, and both proteins are required for BDNF–TrkB early endocytic trafficking and spatiotemporal regulation of BDNF-induced ERK activation."

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"Nonetheless, BDNF dependent ERK1/2 activation has been found significant for the perseverance of two aversive learning tasks ( xref , xref ). xref have suggested that ERK signaling is a conserved mechanism and significant for memory determination."

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"BDNF induced activation of ERK but not PI3K signaling pathway was interfered with the Al (malt) 3 pretreatment, resulting in the subsequent reduction of BDNF induced phosphorylation of 4EBP1, p70S6K, and eIF4E."

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"Consistent with this finding, knockdown of Endophilin A1 resulted in decreased ERK activation by BDNF ()."

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"However, BDNF activation of phospho-TrkB and phospho-Erk1/2 is attenuated, and is associated with reduced BDNF-mediated survival and phenotypic maintenance of R6/2 cultures."

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"BDNF induced ERK, Akt and Src (a non-receptor tyrosine kinase) activation in astrocytes."

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"The authors showed that suppressed Retrolinkin expression prevents TrkB internalisation under BDNF stimulation and activation of ERK, resulting in reduced dendrite growth of CNS neurons."

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"BDNF activates striatal ERK1/2 which, unlike glutamate induced activation of Akt, ERK1/2 and CREB is not blocked by a PI 3-kinase inhibitor [XREF_BIBR]."

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"We focused on several aspects of brain derived neurotrophic factor (BDNF) signaling because BDNF activates the extracellular signal regulated kinase (ERK) cascade, promoting neuronal differentiation including neurite outgrowth."

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"In contrast, BDNF induced Erk signaling was normal, inferring that PSD-95 knockdown did not affect TrkB receptor activation."

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"This analysis showed that 20 ng/ml of BDNF activated Erk activity in the hippocampal neurons, in the absence of ephrin-A5 (XREF_FIG, lane 3)."

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"Moreover, neuronal-activity-enhanced TrkB-FL recycling could facilitate receptor translocation to postsynaptic density and enhance BDNF-induced extracellular signal-regulated kinase and phosphatidylinositol 3-kinase activation and rat hippocampal neuron survival."

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"To verify that ERK activation relies on pTrk early endocytic trafficking, we analyzed endosomal membrane fractions prepared from BDNF-stimulated cortical neurons and found that most pERK1/2 signals were detected in the early endosomal fractions 30 min after BDNF addition and that knockdown of retrolinkin or endophilin A1 caused a decrease in pERK1/2 levels in the early but not late endosomal fractions ( xref ), indicating that both retrolinkin and endophilin A1 are required for BDNF-induced ERK activation on early endosomes."

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"Targeting BDNF receptor tropomyosin receptor kinase B (TRK-B) with siRNA knockdown substantially downregulated the activated (phosphorylated) form of serine/threonine specific protein kinase (AKT) and extracellular signal regulated kinase (ERK), classical survival and proliferation mediators."

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"Activation of ERK1/2 by BDNF promotes cell survival in hippocampal cultures (Hetman and Gozdz, 2004) and seems to exhibits a protective effect in ischemic episodes (Wang et al., 2017)."

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"In cultures of cortical neurons, BDNF activates ERK1/2 via phosphoinositide-dependent kinase-1, and the decrease of BDNF causes a reduction in the levels of ERK1/2 phosphorylation ( Kharebava et al., [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Microinjections of BDNF into the spinal cord or release of endogenous BDNF activate ERK in TrkB-IR STT neurons (Slack et al., 2005)."

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"Ephrin-A5 application attenuated BDNF stimulated ERK activity by suppression of ERK phosphorylation."

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"BDNF/TrkB and NT3/TrkC signaling complexes have been shown to promote CSCs survival via AKT and Extracellular signal–Regulated Kinases (ERK) pathways in glioma [70]."

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"One could be that BDNF induced activation of ERK signaling may lead to increased expression of these genes."

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"It has been shown that quercetin may induce the expression of the brain-derived neurotrophic factor (BDNF) which in turn activates the ERK and PI3K pathways [78]."

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"This suggests that ephrin-A5 counteracted ERK activation by BDNF ( xref )."

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"Thus, BDNF and likely D1 signals trigger an ERK sensitive heterologous signaling pathway to activity-dependently modulate group I mGluRs."

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"Therefore, KSR1 is specifically involved in antigenotoxic activation of ERK1/2 by BDNF."

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"Of particular note, this effect of VTA BDNF on cue induced reinstatement is ERK activity dependent, as it is blocked by U0126, an inhibitor of MEK, the upstream kinase that phosphorylates ERK."

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"In a remarkable model recently discovered by Park et al. [XREF_BIBR], the dopamine D1 receptor agonist or brain derived neurotrophic factor (BDNF) activated ERK1/2, leading to inducible and reversible phosphorylation of mGluR5 at S1126 in striatal neurons as detected by a phospho- and site specific antibody (XREF_FIG)."

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"These findings, together with our data, indicate that activation of ERK1/2 by BDNF can stimulate MEF2-dependent transcription by inducing SIK1 expression ( xref ) followed by the nuclear export of HDAC5 ( xref ) and by the direct phosphorylation of MEF2C by RSK2 xref ."

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"These results not only indicate that retrolinkin and endophilin A1 play a regulatory role in BDNF induced ERK activation, but they also suggest their involvement in ERK signaling from vesicles."

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"Additionally, BDNF application induces the activation of ERK but not p38 MAPK after the equivalent of two pairing sessions."

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"BDNF-Induced ERK Activation Is Enhanced Upon Either D1R- or AMPAR/NMDAR-Mediated Signaling Blockade."

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"We found that BDNF activation of ERK and PI3K was mutually independent."

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"This unexpected result indicated that ERK could also be activated by k252a, possibly through other signaling pathways, rather than by BDNF and TrkB signaling."

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"One of the works demonstrated that the activation of ERK1/2 by the neurotrophin BDNF is important for the persistence of two aversive learning tasks (Bekinschtein et al., xref )."

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"The activation of ERK by BDNF was also attenuated after TrkB blocking."

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"In addition, direct infusion of BDNF into the brain did not increase ERK signaling."

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"We confirmed that BDNF activates the MAPK and ERKs and PI3K and Akt pathways."

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"Moreover, we find that TrkB axonal transport mediated by JIP3 could regulate BDNF induced Erk activation and axonal filopodia formation."

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"Brain derived neurotrophic factor (BDNF) was shown to induce the extracellular signal regulated kinase 1/2 (ERK1/2)-mediated phosphorylation of MKL1, resulting in the activation of SRF driven transcri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"XREF_BIBR, XREF_BIBR These findings together with our published data showing lack of BDNF mediated activation of ERK1/2 in mutant huntingtin cells (XREF_FIG and Gines et al. 3) suggest that mutant huntingtin induces neuronal cell death not only by altering p75 NTR and TrkB expression but also their downstream signaling."

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"BDNF treatment can activate Akt and PI3K [XREF_BIBR] and ERK1/2 [XREF_BIBR] signalling pathways, which are, respectively, required for stimulation of Pol I dependent rRNA transcription upon IGF-1 treament [XREF_BIBR] and EGF treament [XREF_BIBR]."

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"Notably, a greater (1.5 fold; p < 0.05; Wilcoxon t-test) Erk1/2 activation at 180min was produced by BDNF compared to GSB-106."

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"We show here that ephrin-A5 inhibits the basal Erk activity and activity induced by both BDNF and FGF."

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"While BDNF activates both the PI3K and Akt and the ERK pathway, olesoxime induced only a late activation of the ERK pathways, which did not seem to play a major role in its neuroprotection against CPT."

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"In cultured rat cortical neurons, BDNF activates ERK1/2 to enhance neuronal survival by suppressing DNA damage- or trophic deprivation-induced apoptosis."

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"Notably, reduced BDNF induced ERK1/2 activation increases the sensitivity of mutant huntingtin striatal cells to oxidative damage."

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"EtOH decreased ERK activation in vivo and decreased nuclear translocation of BDNF stimulated ERK in situ."

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"Hence, CPDD lowered activity of ERK1/2 phosphatase (s) terminating ERK1/2 signaling that was activated not only by BDNF, but also, by NMDA."

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"Furthermore, in comparison with BDNF, the kinetics of GROalpha/KC induced activation appeared to be different : ERK1/2 activation by 200 ng/ml BDNF occurred faster -- reaching a maximum at 15-30 min a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Ethanol decreased basal pERK and reduced the magnitude of BDNF stimulation of ERK under both conditions."

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"BDNF injection into NAc core, but not NAc shell, led to a protein synthesis- and extracellular signal regulated kinase dependent increase in cell surface GluA1 and a trend towards increased total GluA1."

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"In addition, blocking hippocampal BDNF function resulted in decreased phosphorylation of ERK2 and impairment of STM while intrahippocampal infusion of recombinant human BDNF increased ERK1/2 activation and facilitated STM."

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"This analysis demonstrated that ephrin-A5 aggregation enhanced its activity and that the ligand also inhibited Erk activation by BDNF."

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"These inhibitors did not rescue BDNF-induced ERK1/2 activation ( xref ), suggesting that the PI3K/PDK1 pathway is not required for the G i -dependent blockade of TrkB activation."

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"The intracellular activation of ERK by BDNF is postulated to proceed by signaling through the BDNF receptor tropomyosin related kinase B (TrkB), as has been proposed in other systems."

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"In addition, brain derived neurotrophic factor and growth factors also induce the ERK signaling and here, receptor coupled tyrosine kinase activation has an association."

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"The neurotrophin brain derived neurotrophic factor (BDNF), which can activate the Ras and ERK cascade following binding to its specific receptor TrkB, is able to potentiate glutamatergic synaptic tran[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"It is important to note that we have not directly demonstrated, in vivo , the connection between BDNF-dependent ERK activation and epigenetic regulation of the Homer1 promoter."

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"In addition to BDNF activation of ERK, several other signaling pathways bypass TrkB receptors but nonetheless converge on ERK phosphorylation (XREF_FIG)."

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"Additionally, in vitro experiments on R6/2 striatal cultures show that BDNF activation of phospho-TrkB and the Erk1/2 pathway is impaired in association with a reduction in BDNF mediated neurotrophic effects on MSNs."

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"The activation of ERK by BDNF was also attenuated after TrkB blocking."

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"On the other hand, ERK and CREB phosphorylations were not affected in the absence of PIKE (6 th and 10 th panels), suggesting that PIKE selectively mediate BDNF triggered PI3K and Akt signaling but not the Ras and ERK cascades."

reach
"Previous literature has reported that soy isoflavones have neuroprotective effects may be partially due to suppression of oxidative stress and activation of the Erk/CREB/BDNF signaling pathway, suggesting that BDNF may be a downstream target of Erk."

reach
"Brain derived neurotrophic factor (BDNF) activates various intracellular signals such as phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt), and extracellular signal regulated kinase (ERK)."

reach
"In that study, the PI-3K inhibitor LY294002 blocked BDNF induced ERK activation."

reach
"Clinically relevant concentrations of ethanol inhibited axon outgrowth and the activation of the SFK-Cas-ERK1/2 pathway by netrin-1, GDNF, and L1, but did not disrupt BDNF induced axon outgrowth or ERK1/2 activation."

reach
"These findings are evidence that the GSI, but not the GSM, negatively impacted BDNF induced Erk1/2 signaling."

sparser
"Influx of calcium, mediated either by L-type voltage-sensitive calcium channels or glutamate receptors, is associated with the suppression of brain-derived neurotrophic factor (BDNF) activation of Ras and its effectors Erk and Akt."

reach
"For instance, BDNF and NT-3 bind to high-affinity tyrosine kinase receptors, TrkB and TrkC, respectively, and activate the ERK1/2 signaling pathway to influence growth, development, differentiation, and survival of neurons [XREF_BIBR]."

sparser
"In this same model, elevated BDNF levels parallel activation of ERK, and levels of both BDNF and active ERK are increased by hypothermia [ xref ]."

reach
"Together, these results suggest that BDNF produces a rapid ERK dependent increase in GluA1 protein synthesis that leads to increased GluA1 surface expression."

reach
"BDNF signaling activates ERK1/2 and Fyn and potentiates N-methyl-D-aspartate receptor (NMDAR) signaling through ERK1/2 and Fyn dependent mechanisms."

sparser
"Activation of ERK1/2 by BDNF promotes cell survival in hippocampal cultures ( Hetman and Gozdz, 2004 ) and seems to exhibits a protective effect in ischemic episodes ( Wang et al., 2017 )."

reach
"BMS-299897 treatment elicited a much less robust of activation of ERK by BDNF at 5 min, as compared to responses in cultures treated with either vehicle or sGSM41 (XREF_FIG)."

reach
"Previous studies have showed that BDNF contributes a protective effect against the neurotoxicity of Abeta peptide by activating the TrkB and ERK1/2 signaling (Doi et al., 2013) and repairs the damage [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Indeed, the GSI-mediated effect on BDNF-induced Erk1/2 activation and nuclear translocation of pCREB are evidence for this possibility."

reach
"Among these three pathways, MEK and ERK pathway is activated by BDNF in the spinal cord during colitis [XREF_BIBR]; however, it is not involved in BDNF induced NR1 phosphorylation at Ser 896 characterized in the present study."

reach
"Growth factors such as PDGF and FGF-2 and neurotrophins such as NGF, NT3, and BDNF activate ERK and MAPK signaling by binding to tyrosine kinase receptors at the cell surface."

sparser
"BDNF-induced activation of ERK but not PI3K signaling pathway was interfered with the Al(malt)₃ pretreatment, resulting in the subsequent reduction of BDNF-induced phosphorylation of 4EBP1, p70S6K, and eIF4E. Reduced phospho-4EBP1 and phospho-eIF4E hindered the initiation step of translation, which may lead to a reduction in BDNF-induced Arc expression."

reach
"Activated CREB in combination with BDNF mediated activation of the ERK and MAPK pathway in turn increases expression of miR-132 [XREF_BIBR]."

reach
"Intriguingly, PIKE -/- neurons are selectively resistant towards BDNF stimulated PI3K but not ERK activation."

reach
"Previous studies have shown that ethanol decreases brain derived neurotrophic factor (BDNF)-mediated stimulation of extracellular-signal-regulated kinase (ERK) signaling in cerebellar granule cells (O[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"The current study elucidates a mechanism whereby BDNF and TrkB activates ERK regulated CREB phosphorylation in the dmPFC to counteract the effects of cocaine SA and subsequent relapse to cocaine seeking."

reach
"BDNF activates the RAS and RAF signaling pathway and produces ERK, promoting gene transcription through cAMP response element binding protein (CREB) in the cell nucleus."

reach
"We have demonstrated that FTY720-P enhances the production of BDNF, which activates TrkB and ERK1/2 signaling."

reach
"The ensuing elevation in cAMP ultimately leads to increased BDNF expression which subsequently activates the MAPK and ERK pathway, a major pathway involved in cell growth and proliferation [XREF_BIBR, XREF_BIBR]."

sparser
"Mitchell et al showed that activation of Erk1/2 by BDNF caused the phosphorylation of dynein intermediate chain, promoting its recruitment to signalling endosomes xref ."

reach
"We next examined whether the BDNF engineered lentiviral vector increased the levels of activated (phosphorylated) ERK and Akt in the rat hippocampus as an indirect marker of BDNF secretion."

reach
"1NMPP1, but not K252a, blocked BDNF triggered Akt and Erk1/2 activation."

reach
"Furthermore, depletion of RC3 by RNA interference drastically enhances the stimulation of ERK1/2 and neurite outgrowth induced by brain derived neurotrophic factor in hippocampal neurons."

reach
"Moreover, neuronal-activity-enhanced TrkB-FL recycling could facilitate receptor translocation to postsynaptic density and enhance BDNF induced extracellular signal regulated kinase and phosphatidylinositol 3-kinase activation and rat hippocampal neuron survival."

sparser
"In addition to BDNF activation of ERK, several other signaling pathways bypass TrkB receptors but nonetheless converge on ERK phosphorylation ( xref )."

sparser
"6 A, B ), which was consistent with the previous study that Aβ could weaken BDNF-induced Akt and Erk1/2 activation ( Tong et al., 2004 )."

reach
"In this study, we present evidence that retrolinkin functions in the endocytic trafficking of BDNF-TrkB and mediates BDNF triggered ERK signaling in CNS neurons."

reach
"A functional CRE site in the PGC-1alpha co-activator gene, which is activated by BDNF induced activation of ERKs and CREB, mediates PGC-1alpha expression and mitochondrial biogenesis."

sparser
"ANA-12 is able to reduce ERK activation induced by BDNF in astrocytes ( xref ) and prevent ERK activation in neurons ( xref )."

reach
"This finding has been confirmed by Hong et al. , who examined the mRNA levels of BDNF and the mitogen-activated protein kinase 1/2 (MEK1/2), an immediate activator of the MEK–ERK pathway mediated by BDNF, in the leukocytes of MDD patients and healthy controls."

reach
"In rd1 retinal explants, BDNF and CNTF activate the Erk, Akt, and CREB pathways to decrease the apoptosis of photoreceptor cells [XREF_BIBR]."

reach
"The model also simulates late LTP and STC induced by chemical stimuli such as forskolin or BDNF XREF_BIBR, XREF_BIBR, assuming forskolin and BDNF activate ERK and generate relatively low elevations of synaptic and dendritic Ca 2+."

sparser
"Both proteins are required for BDNF early endocytic trafficking and spatiotemporal regulation of BDNF-induced ERK activation (Fu et al., xref )."

sparser
"So it is not surprising that BDNF can activate ERK."

reach
"In contrast, intrahippocampal administration of recombinant human BDNF increased ERK1/2 activation and facilitated STM."

reach
"Bilirubin inhibited NGF and BDNF activation of ERK1/2 in PC12 and primary rat CGN (42)."

reach
"Brain derived neurotrophic factor loop 4 dipeptide mimetic GSB-106 activates TrkB, Erk, and Akt and promotes neuronal survival in vitro."

sparser
"Likewise, treatment of hippocampal neurons with DEX induces the expression of Sprouty4 and its knockdown abrogates the inhibitory effect of DEX on primary neurite formation, dendrite branching and Erk1/2 activation induced by BDNF."

reach
"ERK1/2 is activated by BDNF signaling through the Ras/Raf/MEK signaling cascade (Iida et al., 2001; Ying et al., 2002)."

reach
"It is therefore possible that an enhanced BDNF mediated activation of ERK1/2 and CREB in food restricted rats represents a neuroprotective response to intraventricular infusion."

sparser
"Lastly, in contrast to a complete block of synaptic NMDA receptor activation of ERK by extrasynaptic NMDA receptors, activation of extrasynaptic NMDA receptors had no effect upon ERK activation by brain-derived neurotrophic factor."

reach
"Conceivably, it is the BDNF induced ERK activation causes the slightly increase of dendritic length in the PI3K and Akt defective PIKE -/- neurons."

reach
"Altered BDNF mediated ERK1/2 activation in mutant huntingtin cells is associated with reduced expression of p52 and p46 Shc docking proteins."

reach
"These results suggest that BDNF induced Erk signaling is normal in AS mice, and infer that TrkB receptor activation is intact."

reach
"To verify that ERK activation relies on pTrk early endocytic trafficking, we analyzed endosomal membrane fractions prepared from BDNF stimulated cortical neurons and found that most pERK1/2 signals were detected in the early endosomal fractions 30 min after BDNF addition and that knockdown of retrolinkin or endophilin A1 caused a decrease in pERK1/2 levels in the early but not late endosomal fractions (XREF_FIG), indicating that both retrolinkin and endophilin A1 are required for BDNF induced ERK activation on early endosomes."

sparser
"The intracellular activation of ERK by BDNF is postulated to proceed by signaling through the BDNF receptor tropomyosin-related kinase B (TrkB), as has been proposed in other systems (e.g., mouse hippocampus, xref ; Aplysia , xref )."

reach
"In contrast, brain derived neurotrophic factor (BDNF) stimulated axon outgrowth and activated ERK1/2 without first activating SFK or Cas."

reach
"BDNF induced activations of ErK and CREB which then competed with LPS induced activation of NF-kB for binding to a common coactivator, CREB binding protein."

reach
"Taken together, the results of XREF_FIG - XREF_FIG indicate that classical BDNF activated PI3K and Akt, Mek and Erk, and calcium-calmodulin pathways are not required for BDNF 's enhancement of BMP7 induced Smad phosphorylation and suggest that CK2 activity is required for this synergistic trophic factor effect."

sparser
"Suppression of retrolinkin or endophilin A1 expression inhibits BDNF-induced ERK activation from early endosomes."

reach
"In primary neurons, Nogo attenuates BDNF elicited activation of erk1/2, AKT and p70S6-kinase."

sparser
"In LAR-/- neurons, BDNF-induced activation of TrkB, Shc, AKT, ERK, and CREB was significantly decreased; while in LAR-transfected neurons, BDNF-induced CREB activation was augmented."

reach
"Compared with the control group, expression of TrkB, Erk1/2, and phosphorylated Erk1/2 were markedly increased in cells treated with BDNF, particularly in the ACR + BDNF group."

reach
"The working model of pLTF suggests that IH leads to serotonin release near phrenic motor neurons, activating 5-HT 2 receptors and increasing brain derived neurotrophic factor (BDNF) synthesis; BDNF subsequently activates its high affinity receptor, TrkB, and leads to ERK MAP kinase activation."

reach
"BDNF induced dendritic spine formation is dependent on BDNF mediated regulation of surface expression of TRPC3 voltage gated calcium channels and BDNF mediated activation of ERK1/2 signaling cascades."

sparser
"These results are in agreement with previous studies in primary striatal neurons in which we observed BDNF-dependent ERK1/2 activation and nuclear translocation ( xref )."

reach
"It is well-known that brain derived neurotrophic factor (BDNF) stimulation induces Erk activation in several cells and promotes cell survival."

sparser
"BMS-299897 treatment elicited a much less robust of activation of ERK by BDNF at 5 min, as compared to responses in cultures treated with either vehicle or sGSM41 ( xref )."

reach
"Retrolinkin directly interacts with endophilin A1, and both proteins are required for BDNF-TrkB early endocytic trafficking and spatiotemporal regulation of BDNF induced ERK activation."

reach
"From these observations, we concluded that there is a paracrine signaling network in the DG whereby prolonged Fas activation in immature neurons induces the release of BDNF, which then activates ERK in neural stem cells."

reach
"BDNF activates intracellular signaling pathways that involve mitogen activated protein kinases (MAPK and ERK), which are important for cell growth and differentiation."

reach
"ERK, CREB and Akt phosphorylation was evaluated after neurons were treated with BDNF for 5, 15 and 60 min."

reach
"Our data further suggest that enhanced BDNF and TrkB signaling following EE does not result in activation of the downstream signals, ERK and PLCgamma and PKC pathways XREF_BIBR, suggesting that these pathways may not play a role in EE under the conditions examined in this study."

reach
"In contrast to undetectable changes in BDNF induced Erk activation in the AS-mouse, severe signaling defects were observed in both the PI3K and PLCgamma1 downstream signaling cascades (XREF_FIG)."

sparser
"We also show that activation of extracellular signal-regulated kinase (Erk) by BDNF is required to overcome inhibition by MAG, and that activated Erk transiently inhibits phosphodiesterase 4 (PDE4), the enzyme that hydrolyzes cAMP."

reach
"As represented in XREF_FIG, BDNF stimulation of nodose neurons caused a ~ 3-fold increase in the ratio of pERK to total ERK."

reach
"These results suggest that BDNF mediated activation of ERK pathways does not appear to play a major role in EE mediated neuroprotection."

reach
"TrkB-Ig(2) also reduced spinal extracellular signal-regulated kinase (ERK) activation, it is possible that BDNF contribution to inflammation-induced bladder hyperactivity is via spinal activation of the ERK pathway."

reach
"We further show that brain derived neurotrophic factor (BDNF) stimulates PGC-1alpha-dependent mitochondrial biogenesis by activating ERKs and CREB."

sparser
"These results not only indicate that retrolinkin and endophilin A1 play a regulatory role in BDNF-induced ERK activation, but they also suggest their involvement in ERK signaling from vesicles."

sparser
"In addition these compounds were found to block the TrkB mediated activation of ERK1/2 by BDNF, but did not affect NMDA induced ERK1/2 activation."

sparser
"Hence, these data support the hypothesis that BDNF-induced Erk1/2 activation may play a role in the modulation of apoE and ABCA1 in NHA and U87 MG glial cells."

reach
"To examine if CGRP contributes to ERK1/2 activation, we incubated spinal cord slices in vitro with CGRP and found that CGRP could not activate ERK1/2 after up to 90 min of stimulation; however, parallel studies showed that ERK1/2 was activated by BDNF within 30 min of incubation in these spinal slices (Qiao et al., 2008)."

reach
"In addition, the activation of the ERK and CREB signaling pathway induced by BDNF plays a critical role in hippocampal neurogenesis and cognition improvement [XREF_BIBR]."

sparser
"Clinically relevant concentrations of ethanol inhibited axon outgrowth and the activation of the SFK-Cas-ERK1/2 pathway by netrin-1, GDNF, and L1, but did not disrupt BDNF-induced axon outgrowth or ERK1/2 activation."

reach
"CNB-001 also has BDNF like activity, and BDNF causes the activation of the ERK and Akt pathways."

reach
"BDNF is hypothesized to activate extracellular signal regulated kinase (ERK) by signaling through the BDNF receptor tropomyosin related kinase B (TrkB) that induces synaptic delivery of GluR1 containing AMPARs by translocation of existing receptors into the synapse."

reach
"Likewise, treatment of hippocampal neurons with DEX induces the expression of Sprouty4 and its knockdown abrogates the inhibitory effect of DEX on primary neurite formation, dendrite branching and Erk1/2 activation induced by BDNF."

sparser
"Several factors could underlie the temporal differences of ERK activation by CNTF and BDNF in nodose neurons."

reach
"Release of BDNF could stimulate TrkB receptors and PI3K-Akt and ERK signaling, which is required for ketamine activation of mTOR."

sparser
"BDNF induced activations of ErK and CREB which then competed with LPS-induced activation of NF-кB for binding to a common coactivator, CREB-binding protein."

sparser
"BDNF robustly activated p-ERK and p-Akt within 0.5-2 hr and p-CREB within 0.5-6 hr of infusion into the dmPFC."

reach
"Brain derived neurotrophic factor (BDNF) is also known to activate ERK."

reach
"In our cortical slice model, the ERK and PI-3K and Akt pathways are independently activated by BDNF."

reach
"BDNF and NGF treatments were shown to activate ERK, as the p-ERK expression levels were significantly higher in the NGF, BDNF and combination groups, in comparison with the control group, although this was partly inhibited by PD98059 (XREF_FIG)."

reach
"Intra-CeA BDNF infusion restored the early withdrawal induced ERK signaling dysfunction and inhibited the anxiety like behavior."

reach
"As expected, SL327 pretreatment blocked BDNF induced ERK activation (XREF_FIG left) and reduced basal pERK levels by ~ 70% (XREF_FIG right), whereas ERK activation was not affected by anisomycin (XREF_FIG left and right)."

reach
"BDNF stimulates DA uptake and surface expression through activation of TrkB-receptor linked PI-3 kinase and ERK1/2 activation."

sparser
"However, PD166285 had no effect on BDNF induced ERK and AKT activation, suggesting the specificity of the inhibitor for FGF2."

sparser
"In contrast to undetectable changes in BDNF-induced Erk activation in the AS-mouse, severe signaling defects were observed in both the PI3K and PLCγ1 downstream signaling cascades ( xref )."

reach
"In contrast, the magnitude of BDNF stimulated extracellular signal regulated kinase (ERK) activation was found to be much greater than that of IGF-1-stimulated ERK, such that the difference in magnitude stimulated by BDNF in the presence and absence of IGF-1 did not reach statistical significance."

sparser
"Recent studies suggest that HDAC inhibition, PKC inhibition, inhibition of GSK-3 β via Wnt-mediated signaling, ERK activation and phosphatidylinositol-3 kinase-protein kinase A activation by brain-derived neurotrophic factor, all mediate the actions of VPA."

reach
"In turn, BDNF(ext) activates the ERK cascade by linearly increasing the rate constant for Raf activation."

sparser
"TrkB expression and phospho-ERK activation by brain-derived neurotrophic factor in rat spinothalamic tract neurons."

sparser
"Brain-derived neurotrophic factor (BDNF) activated ERK in the dorsal horn, and anti-BDNF blocked the DRG-induced ERK activation."

reach
"Primary DRG cultures chronically treated with TNF-α showed significant enhancement of mRNA and protein levels of BDNF and trkB receptor, BDNF release and trkB-induced phospho-ERK1/2 signal."

sparser
"For example, activation of extracellular signal-regulated kinase by brain-derived neurotrophic factor (BDNF) in the mesostriatal pathway is required for acquisition of drug-induced sensitization and CPP ( xref )."

reach
"The extracellular signal regulated kinase (ERK) 1/2, a downstream target of BDNF, is activated by the binding of BDNF to tyrosine kinase receptor-B (Trk-B) via the Ras dependent cascade, including phosphorylation (p) of transcription factors such as cAMP response element binding protein (CREB) [XREF_BIBR]."

reach
"One form of pMF induced by acute intermittent hypoxia, pLTF, requires BDNF induced ERK activation."

reach
"Because retrolinkin and endophilin A1 selectively regulate BDNF triggered ERK signaling kinetics, we reasoned that they might play a role in cell surface entry or trafficking pathways for the BDNF-TrkB signal complex to differentially regulate downstream signaling cascades."

sparser
"Rapid activation of ERK1/2 by BDNF is critical for cell proliferation and neuroprotection [ 37 ], but inhibition of MAPK/ERK signaling aggravates hippocampal neurogenesis and impairs the cognitive per[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

sparser
"Furthermore, in comparison with BDNF, the kinetics of GROα/KC induced activation appeared to be different: ERK1/2 activation by 200 ng/ml BDNF occurred faster—reaching a maximum at 15–30 min and then [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Interestingly, and consistent with our model, bath application of BDNF alone activates ERK and results in synaptic insertion of both GluR1 and GluR4 AMPAR subunits."

sparser
"By using an in vitro maturation model, we found that neurons at DIV (day in vitro) 7, around a period when functional synapses start to form and GABAergic inhibition emerges, displayed the most dynamic activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and CREB by exogenous BDNF."

sparser
"To examine if CGRP contributes to ERK1/2 activation, we incubated spinal cord slices in vitro with CGRP and found that CGRP could not activate ERK1/2 after up to 90 min of stimulation; however, parallel studies showed that ERK1/2 was activated by BDNF within 30 min of incubation in these spinal slices ( xref )."

reach
"BDNF induced ERK, Akt and Src (a non receptor tyrosine kinase) activation in astrocytes."

reach
"We next examined the effects of BDNF activity on muscimol dependent ERK activation, as GABA A R activity early in development can lead to BDNF release (Porcher et al., 2011) and exogenous BDNF can ind[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"In the present report, BDNF treatment increased the nuclear accumulation of phospho-ERK1/2 and phospho-CREB in a PLD1 dependent manner."

reach
"BDNF activated AKT and ERK signaling pathways in and promoted the migration of SBC5 TrkB cells, and these effects were attenuated by the pan-Trk inhibitor GNF-5837."

reach
"Rapid activation of ERK1/2 by BDNF is critical for cell proliferation and neuroprotection [37], but inhibition of MAPK and ERK signaling aggravates hippocampal neurogenesis and impairs the cognitive p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"Mature BDNF, upon binding to trkB receptors on neuronal membranes, activates ERK signaling and stimulates synaptogenesis, synapse strengthening and neuronal survival."

reach
"A single BDNF injection into the PFC activates the ERK signaling pathway, changes the phosphorylation of NMDA receptors in the PL by activating Src family kinases (Barry & McGinty 2017) and produces enduring inhibition through normalizing cocaine-mediated extracellular glutamate spillover in the NAcc (Berglind et al. 2009)."

reach
"Increased BDNF signaling at the TrkB receptor should increase activation of ERK, and indeed social defeat increases phosphorylation (or activation) of ERK in the NAc."

reach
"In parallel experiments, we showed that this BDNF treatment activates ERK but not AKT, mTOR or EF2; however, MEK1/2 inhibition did not prevent BDNF induced decreases in AMPAR surface expression."

reach
"In this case, BDNF mimetics selectively activating either PI3K/AKT or MAPK/ERK were found not to exhibit antidepressant activity, which indicates that both post-receptor signaling pathways are essential for this activity."

sparser
"Conceivably, it is the BDNF-induced ERK activation causes the slightly increase of dendritic length in the PI3K/Akt-defective PIKE −/− neurons."

sparser
"ERK1/2 is activated by BDNF and in turn, induces an increase in the neurotrophin levels, through CREB activation, suggesting a relationship between ERK1/2 activation and optimal levels of BDNF in the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

reach
"In support of this hypothesis, our results demonstrate that activation of trkB receptors by BDNF enhances phospho-ERK1/2 signal in TNF-α-pretreated animals, suggesting that a possible intra-DRG BDNF-trkB system could be functionally self-activated under chronic TNF-α exposure."

reach
"To further investigate whether the secretion of BDNF from the immature neurons elicits Erk activation in neural stem cells in vivo, we injected AAV-Nestin-Cre and AAV-hSyn-DIO-optoFAS into the DG of BDNF floxed mice (Bdnf flox and flox; XREF_FIG)."

reach
"In addition, BDNF release and TrkB receptor activation by ketamine has been suggested to lead the activation of ERK and mTORC1 signaling [12,13]."

reach
"Since shERKs but not shPDK1 reduced the BDNF activation of the ERK regulated transcription factor Elk, these results further support the notion that, in neurons, PDK1 is required to activate RSK NTK in an ERK1/2 dependent manner (XREF_SUPPLEMENTARY)."

reach
"In contrast, BDNF stimulated axon outgrowth and activated ERK1/2 without first activating SFK or Cas."

reach
"These data suggest that increased BDNF levels are not sufficient to explain the beneficial effects of mild hypothermia after cardiac arrest, and that exogenous BDNF administration does not increase extracellular ERK signaling."

sparser
"In that study, the PI-3K inhibitor LY294002 blocked BDNF-induced ERK activation."

sparser
"ERK1/2 is a downstream target for the BDNF signaling pathway [ xref ], and BDNF-induced ERK activation sequentially activates the transcription factor CREB protein and neurogenic proteins that are involved in memory formation and synaptic remodeling [ xref ]."

reach
"BDNF injection into NAc core, but not NAc shell, led to a protein synthesis and extracellular signal regulated kinase (ERK) dependent increase in cell surface GluA1 and a trend towards increased total GluA1."

reach
"In line with this, BDNF elicited ERK activation protects cortical neurons against a challenge with the topoisomerase I inhibitor campthothecin [XREF_BIBR]."

reach
"Other research reports indicated that the protective effect of BDNF against apoptosis not only requires the activation of the PI-3K and Akt, but also activate ERK pathways through inhibition of GSK-3beta and activation of cAMP response element binding protein (CREB)."

sparser
"Pretreatment of cells with a pharmacological Trk inhibitor K252a led to suppression of BDNF- or GSB-106-induced activation of Erk1/2 and Akt (Fig.  xref D), thus suggesting that the pro-survival signaling evoked by GSB-106 in serum withdrawn SH-SY5Y cells requires TrkB activation."

reach
"Together, our novel findings that GluN2A- and GluN2B selective antagonists block BDNF induced behavioral and neurochemical effects expand our knowledge of the molecular mechanisms by which BDNF induces prelimbic ERK activation."

reach
"Because glutamatergic neuronal activity enhances the duration of BDNF induced ERK activity in cortical cultures, we investigated whether NMDA receptor activity mediates BDNF induced suppression of cocaine seeking and elevation of ERK phosphorylation in a short access SA-reinstatement model."

reach
"We previously reported that the level of phospho-ERK1/2 was increased in L1 and S1 spinal cord during colitis, and that exogenous BDNF increased ERK1/2 activation in the cultured spinal cord slices within 30 min of incubation (Qiao et al., 2008)."

reach
"BDNF mediated activation of the ERK cascade was found to be continuously impaired by ethanol."

reach
"Such chronic intra-VTA BDNF infusions alone were sufficient to reduce total VTA levels of ERK protein without affecting the levels of phosphorylated ERK, suggesting that BDNF can enhance the efficiency of ERK activation."

sparser
"Furthermore, we provide evidence that during brain development BDNF activates the extracellular signal-regulated kinases (ERK1 and ERK2) and the phosphoinoside-3-kinase (PI-3-K/Akt) pathways."

reach
"37 BDNF has been reported to activate extracellular signal regulated kinase and the phosphatidylinositol-3 kinase (PI3-kinase) pathways."

sparser
"For instance, ERK1/2 activation by BDNF was shown to protect cultured rat cortical neurons against apoptosis induced by DNA damage ( xref ; xref )."

reach
"In our model of learning, BDNF has been shown to activate extracellular signal regulated kinase (ERK) which in turn induces postsynaptic AMPAR delivery that underlies conditioning."

reach
"Although BDNF caused a sustained activation of ERK, it did not evoke any significant change in T-type Ca 2+ channel expression above baseline."

reach
"BDNF and TrkB activation of intracellular ERK has been proposed for other forms of synaptic plasticity described in the mouse hippocampus and in Aplysia."

reach
"Our previous results showed that pre-treatment with BAPTA-AM only suppressed BDNF stimulated PI3K activity but not ERK."

sparser
"Interestingly, ERK and c-fos, which are among the downstream signaling molecules activated by BDNF and its receptor TrkB, are considered markers of central sensitization ( xref )."

reach
"pro-brain-derived neurotrophic factor (BDNF) conversion to BDNF by metalloproteases [XREF_BIBR]) that trigger ERK1/2 associated cascades."

reach
"Here we show that induction of TBI inhibited BDNF and TrkB expression and inactivated the ERK pathway in the hippocampus."

sparser
"We further suggest that CaM KII/IV activity is not required for BDNF-induced ERK activation."

reach
"In bladder afferents, Transient Receptor Potential Vanilloid 1 (TRPV1) is a probable target of NGF and BDNF-mediated ERK activation."

reach
"For example, activation of extracellular signal regulated kinase by brain derived neurotrophic factor (BDNF) in the mesostriatal pathway is required for acquisition of drug induced sensitization and CPP."

reach
"Moreover, BDNF indirectly activated the ERK1/2 signal pathway by downregulating miR-127."

reach
"In a model of TMT induced neurodegeneration, XREF_BIBR showed that phosphatidylinositol 3-kinase (PI3K)/Akt and ERK1/2 activation, triggered by BDNF overexpression, attenuated the TMT induced neurotoxicity in NSCs."

reach
"TCN-201 infusion into the prelimbic cortex inhibited the BDNF mediated increase in pERK and pGluN2A whereas Ro-25-6981 infusion into the prelimbic cortex blocked BDNF induced elevation of pERK and pGluN2B, indicating that both GluN2A- and GluN2B containing NMDA receptors underlie BDNF induced ERK activation."

reach
"This reduction in mature TrkB at the synaptic membrane could exacerbate an Erk signaling impairment caused by reduced synaptic BDNF."

reach
"However, PD166285 had no effect on BDNF induced ERK and AKT activation, suggesting the specificity of the inhibitor for FGF2."

sparser
"Consistently, in the presence of cell-permeable calpain inhibitor III, BDNF-induced activation of ERKs was reduced and became comparable between TMC30 and 42 ( xref )."

reach
"In order to determine whether activation of these pathways are important for BDNF protection, the activation of PI-3K and Akt or ERK pathways by BDNF was blocked pharmacologically with a PI-3K inhibitor (LY294002, 30 muM), an Akt inhibitor (TCN, 10 muM), or an ERK inhibitor (PD98059, 30 muM)."

sparser
"These results demonstrated that NMDA-, but not BDNF-induced ERK activation depends on PI3K and PLC activity."

reach
"More specifically, BDNF promotes ERK activation and cell survival of retinal neurons under hyperglycemic conditions [49]."

reach
"BDNF activation of ERK1/2 appears to involve TrkB as previously shown using TrkB siRNA XREF_BIBR."

reach
"In contrast, PP2 had no effect on BDNF activation of ERK1/2 (XREF_FIG)."

sparser
"BDNF activates striatal ERK1/2 which, unlike glutamate-induced activation of Akt, ERK1/2 and CREB is not blocked by a PI 3-kinase inhibitor [ xref ]."

reach
"In contrast, BDNF activates ERK1/2 without first activating SFK."

reach
"Like CNB-001, the neurotrophic molecule BDNF is also able to activate both the ERK and Akt pathways and prevent cell death in the in vitro ischemia assay (XREF_FIG)."

reach
"BDNF activates ERK pathway in hippocampus neurons."

sparser
"Immunoblotting analysis detected BDNF-induced activation of the MAPK ERK1/2 as early as 5 min (Supplemental Figure S4), with its phosphorylation levels peaking at 30 min and decreasing thereafter ( xref , and Supplemental Figure S4)."

reach
"In a recent article, Gines et al. reported that BDNF dependent activation of the MEK and ERK pathway was significantly decreased in striatal STHdh Q111 cells, while the activation of other TrkB targets, Akt and PLCgamma was unaffected [XREF_BIBR]."