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TNF activates NGF. 69 / 69
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"Masuda et al. found that human AF and NP cells constitutively express both NGF protein and mRNA, and the proinflammatory cytokines IL-1beta and TNF-alpha stimulate the production of NGF XREF_BIBR."
24796761
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"We have now examined whether the induction of TNF alpha in inflammatory lesions contributes to inflammatory sensory hypersensitivity by inducing IL-1 beta and NGF."
9179382
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"Moreover, INF-gamma completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNF-alpha."
8843146
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"TNFα promote the synthesis of substance P (SP), adenosine, calcitonin gene-related peptide (CGRP) and nerve growth factor (NGF) as well as, modulate genes implicated in expression of others cytokines (IL-1, IL-2, IL-6, IL-8, and IFNγ) and induce their synthesis [14]."
21150823
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"NGF elevated inflammatory knee joint and TNF-α and IL-1β stimulate synovial fibroblasts to produce NGF."
27635406
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"Abe et al. demonstrated that IL-1β and TNF-α stimulated the production of NGF by human IVD cells."
33514693
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"Furthermore, only TNF-alpha but not IL-6 or IFN-gamma enhances the production of NGF in human keratinocytes via the Raf-1/MERK/ERK pathway in human keratinocytes and ERK-Inhibitors can inhibit this signaling pathway [XREF_BIBR]."
26600671
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"For instance, TNF-alpha induces IL-1beta, NGF, prostaglandin, NO, adenosine, and growth hormone production."
21056190
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"MC-derived tumor necrosis factor (TNF) induces nerve growth factor (NGF) and participates in nerve fiber elongation in skin hypersensitivity."
31837249
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"TNFα can also upregulate substance P, nerve growth factor (NGF), and vascular endothelial growth factor production, which may induce painful conditions through sensitization of the nervous system and neurovascular ingrowth into the IVD."
29963655
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"In the AF, 7 days of TNFalpha exposure significantly down-regulated gene expression of aggrecan (-5.7 fold), and significantly up-regulated MMP-3 (3.9 fold), MMP-13 (3.1 fold), IL-6 (2.9 fold), and NGF (3.2 fold) (XREF_FIG)."
23438440
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"In addition, treatment of human cultured CD14-positive and -negative cells with IL-1β and TNF-α enhanced NGF mRNA and protein levels."
28677145
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"In calvarial osteoblasts, IL-1beta and TNF-alpha stimulate Ngf and downstream NF-kappaB signaling."
32460020
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"Our results demonstrate, for the first time, that human AF and NP cells constitutively express NGF protein and mRNA, and that the proinflammatory cytokines IL-1beta and TNF-alpha stimulate the production of NGF."
17413467
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"Moreover, INFqt completely inhibited the increase in NGF secretion induced by IL-10 whereas it had no effect on the induction of NGF by TNF- a."
8843146
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"We found that 17beta-estradiol promoted NGF production in AM ESCs but not in control ESCs; TNF promoted NGF production in both AM and control ESCs; and CoCl2 inhibited NGF production in control ESCs, but had no effect in AM ESCs."
25519715
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"Our results show that the simultaneous addition of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) elicited a marked (13-fold) increase of NGF protein released by cultured rat glomerular mesangial cells within 24 h, whereas IL-1 alpha in combination with TNF-alpha, as well as the cytokines alone, did not promote the synthesis of NGF."
1951711
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"However, NGF production in keratinocytes can be increased by histamine and TNF-alpha released from mast cells [XREF_BIBR, XREF_BIBR]."
26600671
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"NGF secretion by astrocytes in the presence of a maximum dose of aFGF was enhanced by the addition of IL-1 beta or TNF-alpha, but not EGF."
1708303
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"These results indicate that TNF-alpha enhances NGF production via the Raf-1 / MEK / ERK pathway in human keratinocytes, suggesting that regulating TNF-alpha is a therapeutic target to control NGF production and subsequent sensory innervations."
19942804
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"Previous work has shown TNFα upregulates NGF in NP and AF cells in vitro, so annular puncture with intradiscal injections of TNFα or PBS may facilitate nerve ingrowth and upregulation of neurotropic factors including NGF and VEGF, while anti-TNFα injection mitigates nerve ingrowth and expression of these neurotropic factors."
29963655
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"For example, TNF triggers NGF synthesis in reactive astrocytes (Pshenichkin et al., 1994) independently of ceramide generation, and/or PKC and MAPK activation (Galve-Roperh et al., 1998)."
11545011
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"Interestingly, all of the reagents except for TNF-alpha enhanced NGF production of both of the cell lines."
9449710
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"Our in vitro mechanistic study further demonstrated that TGF-beta1 but not IL-6 or TNF-alpha, stimulated NGF production by hepatocytes in a dose dependent manner (XREF_FIG)."
25397406
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"The dose responses of TNF and bFGF to stimulate NGF production in the cells are, respectively, similar to those to induce cell proliferation."
8428934
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"Cancer- or TNFalpha-activated Schwann cells release TNFalpha and NGF."
33469141
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"Additionally, TNFA stimulation promoted the upregulation of NGF and CGRP in CD14(-) cells."
32856747
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"Consistent with this finding, in PC12 cell mutants lacking p75NTR expression NF-kappaB activity was not induced by the combined NGF and TNFalpha treatment above the levels observed in cells treated with TNFalpha alone."
16144552
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"Previously, it has been shown that transfection with these chimeras allows for TNF promoted NGF signaling [XREF_BIBR]."
16144552
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"Our in vitro data shows that stromal cell types upregulate NGF when co-cultured with MM cells or recombinant TNF-α, suggesting that MM production of TNF-α may stimulate production of NGF from the bone microenvironment."
31578352
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"TNF-α diffuses from the injured side via cerebrospinal fluid, and activates satellite glia in the contralateral DRG to produce extra nerve growth factor (NGF), which enhances nociceptor excitability, inducing mirror-image pain24."
26109318
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"Altogether, our data strongly suggest that TNF alpha mediated up-regulation of NGF occurs independently of ceramide generation."
9681439
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"The first involves the nonneuronal events: the resident and migratory immune cells produce a vast number of hypernociceptive inflammatory mediators including pronociceptive cytokines TNF-α, IL-1β, and chemokines, nerve growth factor, and kinins, which trigger the release of directly acting hyperalgesic mediators (Verri et al. 2006)."
26236481
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"By immunohistology, IFNgamma, IL-1beta, and TNF-alpha as well as a cocktail of all three cytokines increased NGF immunoreactivity (IR) in the proximal outer root sheath and hair matrix of anagen VI pelage hair follicles."
15875206
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"On the contrary, simultaneous addition of TNF and IL-la, IL- \ ss or IFN-y stimulated the production of NGF in Swiss 3T3 cells to much greater degrees than did each agent alone; these effects were app[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8131840
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"Both exogenous TNF-alpha and TNF-alpha released by astrocytes after stimulation with LPS induce NGF and GDNF production by astrocytes, further demonstrating, albeit indirectly, a neuroprotective role for TNF-alpha."
24277482
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"Interestingly however, we report significant TNFα‐mediated upregulation of NGF and IL‐1β‐mediated increases in NT‐3 from ASCs."
31891121
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"Although recent studies suggest that tumour necrosis factor (TNF)-α and interleukin (IL)-1β mediate NGF activity in human synovial fibroblasts, the regulation of NGF expression in human synovial macrophages remains unclear."
28677145
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"Discussion The present studies have clearly demonstrated that TNF-R1 is involved in mediating the recently described activity of TNF that stimulates NGF production in fibroblasts [4]."
8635583
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"On the other hand, inhibition of the TNF receptor 2 also decreased NGF-dependent survival of neurons [38] ."
27264679
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"Both interleukin-1-beta (IL-1 beta) and TNF-alpha, but not CCK-8 promote NGF synthesis and release from OA cells."
14611111
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"TNFα has been shown to result in the sensitisation of nerve roots and stimulation of nerve growth factor [15,26,27]."
17688691
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"NGF produced by TNF treated fibroblasts has a molecular mass of 13 kDa on SDS-polyacrylamide gel electrophoresis, which is consistent in size with the subunit of mouse beta-NGF, and induces neurite outgrowth in paravertebral sympathetic neurons."
8428934
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"NGF concentration in cell culture supernatant was also significantly increased by TNF-α (2.7-fold; Table 3, p < 0.05) and decreased by added (5Z)-7-oxozeaenol (Table 3, p < 0.05)."
28668088
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"The production of these cytokines and NGF increased in cells treated with TNFalpha compared to untreated cells."
31520851
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"In addition, immune cells, activated during the inflammation, release pro-algesic mediators like tumor necrosis factor-α (TNF-α), interleukins (IL-6, IL-8, IL-1β), protons, nerve growth factor, and prostaglandins which induce inflammatory and neuropathic pain (2, 3)."
26351564
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"TNF-α promotes nerve growth factor (NGF) expression and contributes to peripheral sensitization in OA mice [6]."
28668088
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"TNF-alpha treatment of F4/80-cells from injured IVDs upregulated NGF, VEGF, cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase-1 (mPGES1)."
29508435
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"Epidermal growth factor (EGF), interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) also increased NGF secretion by astrocytes to a certain extent."
1708303
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"TNF stimulates the synthesis and secretion of NGF also in other cells such as human glioblastoma cells."
8428934
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"Recent preliminary evidence suggests that the pro inflammatory cytokine tumour necrosis factor alpha (TNFalpha) and growth factor withdrawal can both activate a common apoptotic pathway in nerve growth factor (NGF)-responsive PC12 cells involving caspase 3, albeit through very distinct upstream pathways : the former through active signalling and the latter through passive or lack of survival signalling."
12882321
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"We have synthesized four kinds of reversed peptides of various physiologically active peptides, which inhibit TNF (tumor necrosis factor) cytotoxicity, produce NGF (nerve growth factor), exert antimicrobial activity and inhibit cell attachment, respectively."
8996647
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"TNF-α stimulates the activity of monocytes and macrophages, enhances their cytotoxicity and activates the production of several proteins (IL-1, IL-6, granulocyte colony stimulating factor 3 (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and epidermal growth factor (EGF)) [18]."
31775763
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"In conjunction with IL-1, TNF-alpha stimulates the release of NGF from astrocytes, which may explain some of its neuroprotective effects."
23248582
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"Swimming attenuated the TNF-induced increase of BDNF and NGF; this effect lasted until day 49, 1 wk after exercise (NGF: days 42, P < 0.01; days 49, P < 0.05; BDNF: days 42 and 49, P < 0.01; compared with the TNT/no-swim group)."
28846565
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"In this period, we detected nerve growth factor (NGF)/p38-dependent upregulation of inflammatory markers, including TNF-alpha, nitric oxide synthases and cyclooxygenase (COX) 2, in db/db mice [XREF_BIBR]."
23672639
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"TNF alpha stimulation of NGF secretion was shown to be independent of protein kinase C, abrogated by the tyrosine phosphoprotein phosphatase inhibitor phenylarsine oxide (PAO), and independent of the activation of the mitogen activated protein kinase (MAPK) cascade."
9681439
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"TNFα upregulates NGF in IVD cells, and nociceptive nerves, usually restricted to the outer AF in normal healthy IVDs, can be stimulated with NGF to grow into the inner AF and NP as was found in the painful human IVDs."
29963655
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"In addition, we observe that not only exogenous TNF-alpha but also TNF-alpha produced by astrocytes induce NGF and GDNF production in astrocytes."
16956589
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"However, the role of immune cell-generated NGF in pain sensitisation in future studies should not be discounted.IL6 is a known to be responsive to TNF-α, and the induction of NGF by TNF-α is more modest in vitro than the IL6 response."
31578352
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"TNF drives inflammatory activity in immune cells such as T and B lymphocytes as well as in non immune tissue-resident cells such as fibroblasts and epithelial cells, and NGF controls the growth and maintenance of neurons and the perception of pain."
23334208
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"Thus, NGF production during inflammation might be involved in the modulation rather than in the induction of the joint inflammatory response.The findings of the present study suggest that the elevated production of TNF-α and IL-6 in the acute phase after MIA injection may have induced elevated production of NGF and that these elevated proinflammatory cytokines are involved in the modulation of joint inflammation."
21679434
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"All cytokines tested except TNF-alpha enhanced NGF production in both the types of cells, suggesting that the local NGF synthesis after skin injury by residential cells is regulated by these cytokines[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
14699974
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"Here, we show that tumor necrosis factor (TNF)-alpha, but not interferon-gamma or interleukin-6, enhanced the NGF production in human keratinocytes."
19942804
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"During inflammation, NGF synthesis is induced by inflammatory cytokines (IL-1β, TNF-α, IL-6) in different cell types."
31812953
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"Similarly, in synovial fibroblasts isolated from patients with osteoarthritis, both IL-1β and TNFα were shown to increase NGF synthesis and release [27]."
18727839
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"In this study, we have investigated whether TNF-R1 or TNF-R2, or both are involved in mediating a newly described activity of TNF that stimulates NGF production in fibroblasts."
8635583
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"For example, in vitro experiments have shown that TNF can induce the secretion of NGF (Gadient et al., 1990)."
8823387
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"Inflammatory cytokines, like IL-1β, IL-6, and TNF-α stimulate production of NGF in several cell types."
31812953