IndraLab

Statements

BRAF binds KRAS and PIK3CA. 16 / 16
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"There are some evidence that PIK3CA mutations associated with activation of KRAS- BRAF mutation occurring in colorectal cancers ( xref )."
| PMC
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"Moreover, mutations in KRAS and other genes such as BRAF and PIK3CA are also associated with worse survival [ xref ]."
26943031
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"Our findings indicate that somatic mutations in KRAS and PIK3CA but not BRAF oncogenes are closely associated with the development of CCA in Chinese population and provide new potential targets for future therapeutic treatments of the disease."
21051183
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"Furthermore, mutations in KRAS, BRAF, or PIK3CA were not clearly associated with Selumetinib resistance."
25379021
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"The presence of a mutation in pathway effectors downstream of KIT or PDGFRA , such as BRAF , KRAS or PIK3CA , was associated with poor prognosis."
29636989
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"Mutations in KRAS, BRAF or PIK3CA were associated with poor prognosis, while the deficient DNA mismatch repair status was not associated with the prognosis."
28685592
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"In a larger study (N = 586), the presence of a mutation in any of PIK3CA, BRAF or KRAS was associated with poor three-year survival, but the effect of PIK3CA mutation in isolation was not studied ( xref )."
22357840
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"In metastatic colorectal cancer, mutations in KRAS , BRAF and PIK3CA are associated with resistance to treatment with monoclonal antibodies cetuximab and panitumumab, which target the extracellular domain of EGFR (Di Nicolantonio et al, xref ; Lievre et al, xref ; Sartore-Bianchi et al, xref )."
20432502
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"In addition, mutations in KRAS , BRAF and PIK3CA are associated with a worse outcome in patients with colorectal cancer xref , xref ."
20098682
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"However, mutations in K-RAS , b-Raf , and PIK3CA are associated with resistance to anti-EGFR therapies ( xref )."
24273467
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"BRAF , KRAS , and PIK3CA mutations were not significantly associated with cancer diagnosed within 5 years after colonoscopy."
24047059
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"In the patient group with wild-type KRAS , the presence of BRAF mutation or PIK3CA mutations was associated with lower disease control rate (DCR), shorter progression-free survival (PFS), and shorter overall survival."
24500024
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"No significant interaction of PIK3CA mutation with BRAF or KRAS mutation was observed in survival analysis."
22357840
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"This analysis evaluated the association of K-ras, BRAF, and PIK3CA gene mutations with tumor resistance to panitumumab alone."
18621636
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"We studied the presence of CIMP phenotype, MLH1 promoter methylation and MSI phenotype and their association with the presence of KRAS , BRAF and PIK3CA mutations in the series of polyps."
18782444
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"Stage; grade; obstruction; and BRAF , KRAS , and PIK3CA mutations are strongly associated with sidedness."
29241223