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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BRAF binds RAF1 and kinase domain. 2 / 2

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sparser

"However, in the presence of the RAF inhibitor PLX4720, this CRAF-BRAF heterodimer kinase domain interaction is destabilized."

26882073

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sparser

"Previous work showed that, in quiescent cells, the NTRs of BRAF and CRAF associate with their kinase domains to enforce a repressed state, and this was released upon RAS-GTP binding to their RBDs xref – xref ."

29433126

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...