IndraLab

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MYC activates cell cycle. 430 / 436
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"Moreover, Myc antagonizes the activity of cell cycle inhibitors as p21 and p27 through different mechanisms."
24704206
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"AKT activation via growth factors promotes c-myc transcription and accelerates cell cycle progression through enhanced expression of D cyclins, and minimizes negative regulators of the cell cycle process such as p21Cip1 and p27Kip1 resulting in a faster exit from the G0 phase XREF_BIBR, XREF_BIBR."
27760304
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"Antioestrogen treatment, including aromatase inhibitors, tamoxifen and faslodex, all downregulate MYC mRNA inducing cell cycle arrest."
26954716
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"An intriguing possibility is that HSCs may “sense” proteostasis disruption through proteasome load, and resulting stabilization of c-Myc occurs to promote cell cycle entry which can restore proteostasis through division mediated dilution."
32452878
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"C-myc regulates the miR-17 polycistron to modulate cell cycle control through p21."
20406979
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"53 Translational control regulates the expression of cyclin D1, c-myc, FGF and other mediators of cell cycle progression, cell growth and proliferation."
19291795
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"It has been demonstrated that the exaggerated activity of c-myc and E2F accelerates cell cycle progression but also triggers apoptosis induced by various apoptotic stimuli."
11311240
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"BCL-x (L) and BCL2 delay Myc induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin dependent kinases."
12420213
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"It is now clear that c-Myc is closely related to the cell cycle process, and the molecular mechanism by which c-Myc stimulates the cell cycle has been well elucidating."
34395295
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"At the transcription level, CDC25B is also a target of MYC and they may mediate MYC induced cell cycle activation and/or apoptosis [XREF_BIBR]."
27863420
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"A recent report showed that elevated MYC expression in oligodendrocyte precursor cells (OPCs) keeps these cells in undifferentiated state and promotes their proliferation by regulating expression of cell cycle and nucleosomal genes XREF_BIBR."
27282637
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"Since both Myc and beta-catenin are able to promote cell cycle progression and in some cases survival, we were concerned that treatment with CHIR99021 alone could promote neoplastic growth."
30914792
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"MYC also promotes cell cycle progression by activation of the CDK4, CCND1, CDC25A, and E2F family [25]."
31905596
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"MYC promotes cell cycle progression through the activation of Cdk4, Cdc25A, E2F1, and E2F2 [XREF_BIBR]."
33688372
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"Using the Emu- Myc lymphoma model, our studies reveal that Myc induced cell cycle progression, but not apoptosis, depends in part upon E2f1 and that loss of E2f1 does not affect Myc 's ability to indu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12718877
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"Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27."
31822694
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"The mechanisms by which myc promotes cell cycle progression in B-cells is not known."
10956386
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"Thus S-A ASCL1 can directly drive cell cycle exit by co-ordinated downregulation of the MYC-driven core regulatory circuit that maintains neuroblast identity as well as regulating genes that control the cell cycle directly."
33046535
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"Biologically, Max is essential for Myc mediated cell cycle progression, proliferation, apoptosis, and transformation [33,34]."
24933113
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"Myc controls activation of glycolysis and entry into cell cycle and is required for T and B cell activation (Pollizzi and Powell, 2014; Wang et al., 2011)."
35320716
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"In stark contrast to this assumption, it actually has been found upregulated in terminally differentiated cells, e.g. hematopoietic cell lineages, differentiated muscle and neuronal cells, and it inhi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26748253
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"Growing numbers of experiments reveal that, upon PI3K signaling, c-Myc is activated and subsequently drives the cell cycle through the suppression of p21 and p27 [XREF_BIBR, XREF_BIBR]."
32160736
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"In this system, as well as in human osteosarcoma cell lines, the antimitogenic effect of GCs is associated with either down-regulation of cell cycle stimulators such as CDK2, 4 and 6, cyclin D, c-Myc, and E2F-1, or upregulation of the cyclin dependent inhibitors p21 and p27 [XREF_BIBR, XREF_BIBR]."
26215995
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"High levels of MYC drive growth and proliferation while the switch from MYC to MXD proteins promotes cell cycle arrest and differentiation."
24857747
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"It has been demonstrated that ectopic expression of c-Myc promotes cell cycle progression and induces shortening of the G1 phase [40]."
15922743
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"This is supported by the finding that exogenous Myc expression substantially restores cell cycle reactivation in the absence of polymer synthesis."
18663363
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"Although IL-17-dependent ERK5 activation induced c-myc expression that is known to promote cell cycle progression, IL-17-induced Steap4 may provide the necessary metabolic state of the basal cells for the IL-17-induced proliferative response in the epidermis."
26347473
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"The mechanism of transcriptional repression of p21 by c-MYC has been a subject of intensive study for several years, as it may explain how c-MYC promotes cell cycle progression."
19270520
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"C-Myc drives the cell cycle by promoting progression from G1 to S phase and G2 to M phase."
29715580
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"To understand mechanisms of Myc mediated cell cycle regulation and endoderm repression, we set out to identify in vivo targets for c-myc by ChIP-Chip analysis."
20804970
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"The c-Myc gene activates the transcription of cell cycle-promoting genes such as Cdc25a, CDK4, cyclin D and cyclin E. c-Myc also inhibits the expression of cell cycle growth restriction genes, such as p15 and p21, to significantly promote cell cycle progression 41, 42."
34512161
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"Adenoviral expression of Akt and PKB and c-MYC have been reported to activate cell cycle entry in human beta-cells, but Stat5a has not been assessed."
26159175
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"C-Myc induces most of the critical positive cell cycle regulatory genes to promote cell proliferation, including E2F transcription factors, cyclin dependent kinases (CDKs), and cyclins."
31470030
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"Furthermore, glioma cancer stem cells have been shown to express c-Myc at much higher levels than non stem glioma cells, and c-Myc knockdown was shown to reduce proliferation and cause cell cycle arrest in glioma stem cells XREF_BIBR."
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"In contrast, expression of cyclin E, cyclin A, and Rb phosphorylation were delayed when quiescent c-myc heterozygous cells were stimulated to enter the cell cycle."
8065309
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"Following on from previous studies within this laboratory (Bartlett et al, 1998, 1999; Watters et al, 2000, 2001) which associated specific chromosomal aberrations with recurrence or progression, we hypothesised that alteration of key cell cycle modulators c-myc and CCND1 via gene alterations drives progression of superficial and locally invasive TCC (pTa and pT1)."
12237776
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"In support of this, inhibition of MYC has been reported to cause a G0/G1 block in the cell cycle in human lymphoid and myeloid cells."
29599201
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"CCND and the transcription factor c-Myc are associated with G1/S cell cycle transition and it is well known that FSH mitogenic effect triggers upregulation of CCND1 and c-Myc enabling the progression [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29859192
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"As in ES cells, Myc activity increases the rate of proliferation and reprogramming by helping to establish a pluripotent cell cycle in reprogrammed cells [XREF_BIBR - XREF_BIBR, XREF_BIBR]."
26520682
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"The association between estrogen and ER may also activate some transcription factors such as c-Myc which later replicates genes and induces cell cycle activation."
33748757
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"In this same model, c-Myc is able to induce cell cycle re-entry through the induction of cyclin E1-Cdk2 activity, but without significantly increasing the expression of cyclin E2 [XREF_BIBR]."
20180967
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"Fbxw7 is a mediator of c-Myc and Cyclin E proteolysis modulating cell cycle regulation."
23840897
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"As a result, let-7f was capable of reducing TPC-1 cell growth, and this might be explained, at least in part, by decreased messenger RNA (mRNA) expression of cell cycle stimulators such as MYC and CCND1 (cyclin D1) and increased P21 cell cycle inhibitor mRNA."
19956384
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"So that means the down-regulation of c-Myc should induce the repression CCND2 and cell cycle retardation."
26393798
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"A well-known function of deregulated c-Myc in carcinogenesis is to up-regulate (stimulate, enhance) cell cycle progression and metabolism."
22148260
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"Furthermore, loss of MYC abolished miR-210-mediated override of hypoxia induced cell cycle arrest."
19652553
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"It has been demonstrated that c-Myc, as a heterodimer with Max, cooperates with Miz1 to repress transcription of cell cycle inhibitors such as p15, p21 and p27 XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR."
22384171
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"The ectopic overexpression of let-7g in OVCAR3 and HEY-A8 EOC cells induced i) a down-regulation of c-Myc and cyclin-D2 thus promoting cell cycle arrest, ii) a reduction of Vimentin, Snail and Slug thus counteracting the progression of epithelial to mesenchymal transition, iii) a chemosensitization to cis-platinum treatment."
30952937
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"To examine whether Chk1 activity contributes to MYC mediated proliferation, we employed conditional MYC-ER expressing MCF-10A cells, that after serum starvation are driven to MYC induced cell cycle progression by nuclear translocation of MYC-ER fusion protein in response to tamoxifen treatment."
24072747
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"Tissue culture experiments support a model in which MYC genes stimulate cell cycle progression by antagonizing the function of the cell cycle inhibitor p27 (kip1)."
11307151
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"13 Forced expression of c-MYC induces cell cycle re-entry of quiescent cells, but the downregulation or inactivation of c-MYC results in the impairment of cell cycle progression."
27253416
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"Myc oncoprotein induces transformation basically through cell cycle stimulation.95 Three leading mechanisms are required for cell cycle stimulation by Myc : upregulation of CDKs and cyclins , downregulation of CDK inhibitors p15 and p21 , and degradation of p27 ."
33692331
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"Downregulation of the c-myc gene arrests the cell cycle at G0G1 phase [ 47 ] , resulting in restricted entry of cells in S phase and reducing the number of cells at G2 M phase for viral genome integration ."
20005468
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"Myc knockdown inhibited primary effusion lymphoma (PEL) cell proliferation through inducing apoptosis and G (1) cell cycle arrest."
20573831
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"Indeed, enforced Myc expression in quiescent cells is sufficient to mediate cell cycle entry."
31822694
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"Reducing the proliferation of cancer cells is a way to control cancer cell amplification, and M. oleifera leaf extract significantly reduces the levels of c-myc, p-Bcl2, and Hsp70 to induce cell cycle stagnation [50]."
| PMC
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"Consistent with our previous results [XREF_BIBR, XREF_BIBR], this study demonstrated that depletion of MYC reduced CDK2 activity in MYC dependent cells but not in MYC independent cells, indicative of a role of CDK2 inactivation in MYC inhibition induced cell cycle arrest."
24444383
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"The MYC and related MYCN oncogenes (encoding MYC and N-MYC) are translocated, amplified, or mutated in many cancers, and can dramatically upregulate genes involved in glucose and glutamine metabolism, ribosomal, lipid, and nucleotide biogenesis, and cell cycle progression."
27500134
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"Finally, c-myc promotes cell cycle progression from the G0/G1 phase to the S phase [XREF_BIBR]; its downregulation has been associated with Bax oligomerization and subsequent activation of caspase-9 and caspase-3, resulting in apoptosis [XREF_BIBR]."
23510080
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"Cells with normal growth control can stop cell proliferation machinery to replenish ATP reservoirs whereas MYC prevents such break by blocking the cell cycle exit."
28443281
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"Therefore, TGFbeta induces both c-myc, which stimulates cell cycle progression, and jagged-1, which blocks cell cycle progression through stimulation of Notch and induction of p21."
25566498
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"PKM2 dependent H3 phosphorylation facilitates the dissociation of histone deacetylase 3 from CCND1 and MYC promoters, resulting in subsequent acetylation of H3 at Lys9 and EGF induced cyclin D1 and c-Myc transcription, which promotes cyclin D1 dependent cell cycle progression and tumorigenesis [XREF_BIBR]."
33292198
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"In its genomic action as a transcriptional factor, ERalpha activation in MCF-7 cells can induce the expression of cyclin D and myc to promote cell cycle progression [XREF_BIBR - XREF_BIBR]."
19171042
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"When activated by estrogen, ERalpha, as a transcription factor, can induce the expression of cyclin D and c-myc to promote cell cycle in its genomic action and can activate multiple pathways such as the ERK and AKT pathways to induce mitogenesis in its non genomic action XREF_BIBR; XREF_BIBR."
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"The E2F transcription factors, a family of critical regulators of the cell cycle that are activated by the oncogene c-Myc, were among the first experimentally verified targets of the miR-17-92 cluster [ xref ]."
24278756
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"We conclude that MYC activation during embryonic development causes neonatal hepatocytes to undergo DNA replication, cell cycle transit, proliferation, and almost immediate neoplastic conversion."
15455033
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"Furthermore, Pim phosphorylation and stabilization of c-Myc enhances cell cycle entry 17, leading to the plausible idea that Pim kinases antagonize the aging phenotype and favor ongoing mitotic activity by blunting the impact of cell cycle inhibitors."
24916111
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"MYC proto-oncogene members (MYC, MYCN and MYCL) are targets of RAS signaling and key regulators of numerous downstream pathways such as cell proliferation 131 where enforced Myc expression drives cell cycle in an autonomous fashion."
22054881
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"Accordingly, our data demonstrate that JQ1- and dBET1 mediated MYC inhibition causes cell cycle arrest."
29899872
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"Our results suggest that Bin1 gene suppression caused by oncogenic E1A via Rb inactivation is an essential step in cell cycle progression promoted by c-Myc, and subsequently, E1A transformation."
18348166
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"Monomeric PKM2 translocates into the nucleus, where it functions as a histone kinase and upregulates the expression of c-Myc and cyclin D1, thereby promoting the Warburg effect and cell cycle progression, respectively."
24013426
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"Overexpression of c-Myc causes deregulation of the cell cycle, coordinating both cell growth and concomitant progression through the cell cycle XREF_BIBR."
28959653
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"Thus, reduced survivin expression could inhibit the downstream gene expression of cyclin D1 and c-Myc, which would induce cell cycle arrest and slow cell proliferation, overall reducing glioma cell survival [XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR]."
25722677
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"Although activation of Myc in quiescent fibroblasts can induce cell cycle progression [99] and apoptosis [100], it is not always sufficient [101]."
11250069
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"As short-term activation of c-Myc promotes cell cycle progression, its prolonged activation may result in the initial hyper-proliferation of cells to subsequently undergo cellular senescence [XREF_BIBR]."
26922917
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"The in vitro experiments confirmed that the i-lncRNA expression significantly inhibited cell proliferation, induced cell cycle arrest and apoptosis in DLBCL cell lines, mainly through upregulating the expression of PTEN, p27 kip1, TIMP3, RECK and downregulating the expression of p38 and MAPK, survivin, CDK4, c-myc."
27172795
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"Supraphysiologic concentrations of c-Myc likely stimulate erythroblast proliferation by up-regulating the G1-S cell cycle checkpoint."
25473453
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"It appears that the acceleration of cell cycle progression driven by Myc in B lineage cells is not significantly affected by the loss of E2F2 or E2F4 activities."
19749980
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"Previous studies have demonstrated that MYC inactivation can cause cell cycle arrest, differentiation, and apoptosis, and thus induce tumor regression in many types of tumors [16,17]."
18809243
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"C-Myc stimulates the cell cycle progression through activating genes like cyclin D and cyclin dependent kinase 4 (CDK4) [20]."
29035828
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"They up-regulated a broad range of pro-angiogenic factor expression in vascular ECs; some of them include E-selectin, angiopoietin, FGF-1, cyclooxygenase 2 (COX-2), and cell cycle activator c-Myc [118,119]."
| PMC
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"XREF_BIBR Endoreplication reconciles MYC activation of the cell cycle with epidermal differentiation."
23114621
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"Consistent with a role in proliferation, Mtbp expression was induced by Myc and other factors that promote cell cycle progression and was elevated in lymphomas from humans and mice."
20305689
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"Transcription of C/EBPβ then in cooperation with STAT3 drives MYC expression, which enables accelerated cell cycle progression, leading to increased myeloid cell output including neutrophils."
33373817
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"Significantly, c-Myc, as a key element in Wnt canonical pathway, can accelerate the CSC cell cycle progression and promote CSC reawakening, while their inactivation was closely associated with the entry into reversible quiescence [22–25]."
34482364
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"Besides initiating VSMC proliferation, c-myc is thought to entertain and even stimulate cell cycle pro- gression [18]."
11795828
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"In detail, compared with ov-THAP11 transfection alone, cotransfection of ov-c-Myc with ov-THAP11 significantly upregulation of c-Myc mRNA levels (Figure 5(a)), promoted cell proliferation (Figures 5(b) and 5(c)), and cell cycle progression (Figure 5(d)), while inhibited apoptosis (Figure 5(e))."
32908912
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"MYC protein targets most cell-cycle regulator genes, including cyclins, cyclin dependent kinases, and cell-cycle inhibitors, drives quiescent cells to enter the cell cycle, and promotes cell proliferation XREF_BIBR, XREF_BIBR."
33318499
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"Specifically, Myc promotes proliferation by transcriptionally repressing cell cycle inhibitors, such as p15, p21 and p27, while transcriptionally activating genes, such as nucleolin (NCL), ornithine decarboxylase (ODC), carbamoyl-phosphate synthetase 2/aspartate transcarbamylase and dihydroorotase (CAD), and Cyclin D2 (CCND2) that are needed for ribosomal assembly, polyamine generation, pyrimidine synthesis, and cell cycle progression, respectively."
24786788
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"MYC promotes tumorigenesis by regulating cell proliferation, cell cycle, and genomic instability (Casey et al., 2017)."
34859058
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"FBXW7, the gene that encodes the F-box protein responsible for targeting cell cycle accelerators such as CCNE1, AURKA, and MYC for ubiquitin mediated proteolysis [1], has been found to be mutated in a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17274947
eidos
"Numerous studies have demonstrated that genetic or pharmacologic suppression of either IRF4 or c-Myc expression induces cell cycle arrest and compromises MM viability ."
33499314
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"MYC promotes tumor progression by activating cell cycle related genes and repressing cyclin dependent kinase (CDK) inhibitors, which contributes to uncontrolled proliferation and ultimately, the development of cancers [XREF_BIBR, XREF_BIBR]."
33541412
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"Thus, and in agreement with the fact that Cdk1 could substitute Cdk2 in such task, we set out a series of experiments to elucidate the potential role of Cdk1 on Myc-dependent stimulation of cell cycle progression independently of Cdk2 activity."
31822694
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"Paradoxically, MYC can either drive cell cycle progression or induce apoptosis."
21986497
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"Hence, MYC appears induce inappropriate cell cycle transit, but not mitotic cellular division independent of p27 mediated inhibition of Cyclin E/Cdk2."
16760657
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"MYC promotes cell cycle progression by regulation of pivotal cell cycle control genes through transcriptional induction of CDKs and cyclins, and repression of CIP and KIP proteins."
28040803
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"We found knockdown of INPP4B in A549 with miR-937 knockdown promoted cell proliferation, suggesting INPP4B might function as tumor suppressor in lung cancer cells.We also found miR-937 regulated CCND1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27179609
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"This cumulative increase in c-Myc and cyclin D1 contributes to the cooperativity of these mitogens, since ectopic expression of c-Myc or cyclin D1 cooperates with either the estrogen or insulin signaling pathways to increase cell cycle progression."
15607540
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"IL-6 upregulates the expression of cyclins D1, D2, and B1, and myc by activating STAT3 and thus promotes the cell cycle arrest."
22149093
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"The mature, quiescent MCF10A structures are exceedingly proliferation resistant, being able to prevent Myc induced cell cycle re-entry."
26073086
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"C-Myc drives cell cycle progression at least in part by increasing the expression of cyclin D and cyclin E, and possibly E2F."
12191637
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"The activation of AP1 leads to myc induced cell cycle progression, while the activation of the peripheral clock inhibits myc overexpression and is required for ATM activity."
20539819
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"Given that c-Myc is heavily regulated by the proteasome, promotes HSC cell cycle entry, and influences HSC self-renewal, we investigated whether c-Myc was dysregulated in Aars sti and sti mice."
31914399
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"Research has shown that c-Myc can promote the transcription of positive cell cycle regulatory factors, such as E2F transcription factors, cyclin D1, and cyclin-dependent kinase 4 (CDK4)."
31309249
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"We had observed increased Myc expression in D164A crypts 2d pi, we therefore asked whether Myc driven proliferation was inducing increased cell cycle rate of SCEP cells."
33649334
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"Further, let-7 family members functionally inhibit the mRNAs of well characterized oncogenes, such as the Ras family XREF_BIBR, HMGA2 XREF_BIBR, and c-myc XREF_BIBR induced apoptosis and cell cycle arrest when overexpressed in lung and colon cancer in Burkitt lymphoma cell lines XREF_BIBR XREF_BIBR."
23703335
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"Knockdown of c-Myc in cancer cells in vitro uniformly reduces cell proliferation and in some instances, induces apoptosis and cell cycle arrest."
27572308
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"C-Myc promotes cell cycle progression by multiple mechanisms ."
27697092
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"It has been widely demonstrated that oncogenic MYC promotes cell cycle progression and increases Cyclin E/CDK2 activity, which may be achieved by induction of CCND2 gene expression, inactivation of CDK inhibitor p27 Kip1 or stimulation of E2F transcription factor dependent genes, among other mechanisms."
31930281
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"In nucleus, it acts as a transcription factor, activating the genes encoding for Cycline D1 and C- Myc, finally causing cell cycle dysregulation."
34287240
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"Myc oncoproteins promote cell cycle progression in part through the transcriptional up-regulation of the cyclin D2 gene."
11511535
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"Since, forced expression of c-myc resulted in cell cycle progression, it was suggested that c-myc may be sufficient to induce cells to re-enter cell cycle."
24503550
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"Re-expression of myc activates the cell cycle without inducing apoptosis."
10956386
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"However, they do not exclude the possibility that additional DNA damage or exacerbation of damage generated in G0/G1 may result from aberrant cell cycle progression induced by expression of c-Myc at s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12049739
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"In the nucleus, β-catenin increases expression level of Myc and Cyclin D1 to promote cell cycle progression and increase growth of HCC cells."
34858888
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"XREF_BIBR, XREF_BIBR, XREF_BIBR Loss of c-Myc caused a 12-fold reduction of cyclin dependent kinase (Cdk) 4/6 activity and cell cycle arrest at the G 1 phase."
22926519
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"MYC indeed directly regulates number of genes important for the core cell cycle machinery."
28443281
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"This facilitates survival of eBL tumor cells with the IGH and MYC chromosomal translocation and promotes MYC induced cell cycle progression, initiating eBL lymphomagenesis."
29132323
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"Treatment of ECM-adherent cells with EGF, or overexpression of EGFR or Myc, resulted in restoration of late-G (1) cell cycle events and progression into S phase."
15367678
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"Since the abovementioned results indicated that c-Myc promotes tumor growth in vitro by modulating the cell cycle, the efficiency of injection of the c-Myc shRNA retrovirus in inhibiting tumor formation was then assessed in vivo."
29512702
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"In conclusion, the present study identified c-Myc targeted cell cycle and apoptosis genes in lung cancer and permitted the construction of disease associated molecular circuitries."
26427040
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"The short time period over which these changes were seen supports the idea that MYC induced cell cycle progression occurs through direct activation of key cell cycle genes such as Ccnd1, Ccnd2 and Ccne2."
21961992
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"it has been shown that nuclear EGFR aids in the transcription of important cell cycle progression mediators, including CYCLIN D1 and c-MYC, among other proto-oncogenes [XREF_BIBR, XREF_BIBR]."
28513565
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"Increased amount of Wnt ligands promotes c-Myc transcription and accelerates the cell cycle re-entry of G 0 / G 1 -phased dormant CSCs [XREF_BIBR, XREF_BIBR]."
28289330
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"DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression [14]."
26341817
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"To determine if MYC was inducing changes in cell cycle transit, we measured the DNA content of isolated nuclei from normal hepatocytes and hepatocytes in which MYC was activated during embryonic development (XREF_FIG D and XREF_FIG E)."
15455033
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"The sequestration function of D cyclins thus appears essential for Myc induced cell cycle progression but dispensable for apoptosis."
10508164
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"Furthermore, an in vitro study indicated that c-myc knockdown significantly inhibited ccRCC cell proliferation by arresting the cell cycle in the G0/G1 phase [XREF_BIBR]."
28076379
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"The MAPK member of these pathways activates a transcription factor Myc which then activates the critical positive cell cycle regulators that include Cdks, cyclins and E2F transcription factors [XREF_BIBR, XREF_BIBR]."
26059433
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"C-Myc accelerates the G1/S cell cycle transition through regulation of cyclinD1 and CDK4/6."
27793037
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"It has previously been shown that there is only a narrow window when very early suprabasal cells that have migrated out of the basal layer, are capable of responding to Myc induced cell cycle entry [XREF_BIBR, XREF_BIBR]."
21961992
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"One of the main biological functions of MYC is to promote cell cycle progression 15."
28607447
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"Specifically, omeprazole (OME) promoted cell cycle progression, increased c-Myc expression, ErbB2 activity and PSA secretion."
30790678
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"Activity of FTO could be inhibited by R-2HG, leading to the increase of m 6 A abundance and decreased stability of MYC and CEBPA mRNAs, which subsequently caused growth inhibition, cell cycle arrest and apoptosis of leukemia cells; as a result, R-2HG displays an intrinsic anti-leukemia activity."
32183948
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"Our data indicate that neither the expression of c-myc alone nor of c-myc and bcl-2 led to the complete activation of cell cycle progression."
10626893
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"C-Myc promotes cell cycle progression from the G0/G1 into the S phase by activating cell cycle promoting genes and inhibiting cell cycle suppressors [XREF_BIBR - XREF_BIBR]."
24152439
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"Our findings disclose a novel mechanism by which c-Myc promotes cell cycle progression by suppressing one gene locus that carries both miRNA and protein coding gene."
22210897
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"Co-activation of cell cycle activator Myc and inner ear progenitor gene Notch1 induces robust proliferation of diverse adult cochlear sensory epithelial cell types."
31797926
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"Overexpression of c-Myc stimulates cell cycle progression, whereas Myc downregulation exerts the opposite effect."
26300071
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"Myc promotes the cell cycle primarily through its role in cellular growth control."
33402669
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"Ectopic expression of c-Myc in quiescent cells is sufficient to induce cell cycle entry in the absence of growth factors."
27711077
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"Therefore, Myc does not require E2f1 to induce Arf, p53, or apoptosis in B cells, but depends upon E2f1 to accelerate cell cycle progression and downregulate p27 (Kip1)."
12718877
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"Together, our data indicate that the converged effect of MYC-promoted cell cycle progression and CDK7 inhibition by THZ1 confers the hypersensitivity of HCC to DNA-damage-induced cell death."
35406486
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"This suggests that in proliferative cells, c-Myc does not trigger cell cycle progression per se, but rather directs cell growth and hence allows cells to reach the critical size required for G1/S prog[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12834864
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"Downregulation of c-MYC by JQ1 induced cell cycle arrest and apoptosis in ovarian cancer cell lines and downregulated lactate dehydrogenase A (LDHA) resulting in decreased lactate production and reduced energy supply."
26908627
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"DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells."
22307329
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"During early G1 phase, the elevated c-myc protein plays a critical role in promoting G1/S progression [13,29-31] : c-myc induces cell cycle progression in fibroblasts acting as an upstream regulator o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17568564
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"Early studies performed in cell lines and more recent studies in primary keratinocytes resulted in the prevailing view that Myc stimulates cell cycle entry while inhibiting differentiation."
17998397
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"Surprisingly, transformed cells expressing HIF2alpha exclusively exhibit enhanced MYC activity, with more rapid entry into S phase of the cell cycle, increased CCND2, E2F1, and ODC1 gene expression, and elevated MYC promoter occupancy 110 Moreover, HIF2alpha promotes cell cycle progression in hypoxic cells via transcriptional effects on both MYC activated (CCND2, E2F1) and repressed (p21, p27) target genes, and interactions with MAX, SP1, and MIZ1."
22169972
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"In fact, high PU.1 levels similarly delayed HSC first division while simultaneously priming their progeny to undergo accelerated proliferation via induction of myeloid lineage determinants and cell cycle activators including Cdk4, Myc, Ccnb and Ccne1 (XREF_FIG)."
27111842
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"Inhibition of MYC expression, down-regulation or inactivation of MYC in cycling cells results in cell cycle arrest and impairs cell cycle progression in various cell lines, including human lymphoid and myeloid cells [XREF_BIBR - XREF_BIBR]."
26472107
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"In conclusion, we demonstrated that Fbxw7 can be activated by adenoviral delivery of p53, leading to increase proteasomal degradation of c-Myc and Cylin E. Low levels of the studied cell cycle regulators might attenuate the oncogenic phenotype of HCC cell lines by restricting G1-S transition and c-Myc mediated cell cycle reentry."
23840897
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"We found that in cells overexpressing ChREBP, numerous cell cycle accelerators (including cyclin A, cdk1, cdk2, cdk6, and c-Myc) were significantly increased and a number of cell cycle inhibitors (including p57, p15, p18, and p19) were significantly decreased."
22586588
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"Overexpression of c-Myc has been shown to cause increased cell proliferation, cell cycle progression and inhibition of apoptosis in endometrial cancer [XREF_BIBR]."
27572308
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"MYC overexpression induced cell cycle entry causes apoptosis in the absence of strong pro survival effects from BCL2 or activated tyrosine kinase growth factor receptors."
25639793
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"Oncogenic MYC activation promotes proliferation in Burkitt lymphoma (BL), but also induces cell cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of BL cases."
31000522
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"It has been also shown that elevated c-Myc activity is able to abrogate the cell cycle suppressing effect of TGFbeta1; the mouse keratinocyte cell line (BALB/MK) constitutively expresses endogenous c-myc, and showed resistance to the arrest of growth by TGFbeta1 [XREF_BIBR]."
19061498
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"We also noted that the inhibitory effect of MYC siRNA on cell proliferation was not dependent on retinoblastoma protein (pRb) status, as five pRb deficient cell lines (BT549, MDA-MB-436, HCC70, MDA-MB-468 and HCC1937) were all responsive to MYC depletion, implicating both pRb dependent and pRb independent mechanisms underlying MYC stimulated cell cycle progression."
24444383
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"C-MYC is an upstream activator of cyclin-E and CDK2 activity and promotes cell cycle progression from G1 to S phase independent of the Rb pathway and can compensate for low cyclin D/cdk4 kinase activity, whereas p16 arrests this transcriptional activity at the G1 phase."
26954716
reach
"Activation of MYC causes cell growth, loss of differentiation and cell cycle entry in both beta-cells and suprabasal keratinocytes in vivo."
21961992
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"MYC modulates cell cycle progression by regulating the expression of cell cycle regulators [37,40,41]."
18809243
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"PS-MYC peptide treatment also markedly downregulated the expression of MYC mediated cell cycle and survival genes while upregulating the expression of MYC suppressed target genes (XREF_FIG)."
33491667
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"E2F1 (E2F transcription factor 1) is a target of c-Myc that promotes the cell cycle [28]."
32156290
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"Likewise, knockdown of the MYC repressed MYCLos alters the cell cycle."
26003165
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"Over a dozen miRNAs such as the miR-17-92 cluster and miR-9 have been found to be induced by c-Myc to manifest its function in cell cycle, survival, metabolism, apoptosis and metastasis."
22887866
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"AP1 activation leads to myc induced cell cycle progression, while the activation of the peripheral clock inhibits myc overexpression and is required for ATM activity."
27036047
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"Furthermore, simultaneous Cre-Lox mediated deletion of Mnt and c-Myc in mouse embryo fibroblasts rescued the cell cycle entry and proliferative block caused by c-Myc ablation alone."
15866886
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"C-MYC is a well-known stimulator of the cell cycle, and is known to be expressed in the neural plate border and to be required for the induction of NC cell precursors."
26873953
reach
"Suprabasal keratinocytes at an early (spinous) stage of differentiation are induced by c-Myc to reenter the cell cycle and proliferate whereas more differentiated granular cells instead become large h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10360173
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"Ectopic MYC is sufficient to induce cell cycle progression and proliferation."
24727092
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"Myc directly induces expression of cell cycle regulators, including Cyclin D, Cyclin E and E2Fs."
30419347
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"Consistently, the loss of c-Myc reversed the cell cycle arrest and apoptosis induced by USP18 overexpression in SW1990 cells (XREF_FIG - XREF_FIG)."
33051403
reach
"Interestingly, it appears that Myc not only drives the cell cycle, but also induces cell death by apoptosis in certain situations."
7948108
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"In a mouse transgenic model of Myc dependent beta-cell carcinogenesis, the onset of endothelial cell proliferation was noted to begin shortly after Myc induced cell cycle entry of pancreatic beta cells."
18941463
reach
"One of the mechanisms for MYC to promote cell proliferation is to antagonize the activity of cell cycle inhibitors, such as p27."
33533173
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"Seliciclib further up-regulated the transcriptional activity of c-Myc, a cell cycle gene that promotes cell cycle entry and G1-S transition (p < 0.001), and down-regulated that of Wee1, which gates cell cycle transition from G2 to M (p < 0.001)."
19731111
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"12 Due to this process, cell cycle stress induced in human keratinocytes by proto-oncogene MYC, the DNA replication regulator Cyclin E, or by inactivation of tumour suppressor p53, does not result in cellular transformation, but in a G2/M block that in turn induces squamous differentiation and polyploidy."
28661481
reach
"Gil et al. demonstrated that c-Myc can promote cell cycle progression regardless of the presence of growth factors XREF_BIBR."
21423728
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"In addition, the conditional activation of c-Myc in quiescent cells induced cell cycle entry and promoted cellular proliferation in vitro [49,50] and in vivo [51,52]."
24735945
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"XREF_BIBR, XREF_BIBR Additionally, TGF-beta also inhibits expression of Cdc25a phosphatase, which is necessary for cyclin and CDK complex activation and negative regulation of factors including Id protein, E2F, and c-Myc driving the cell cycle progression and cell proliferation."
26229489
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"It was reported that K323 overacetylation might cause reduced c-Myc protein stability while preserving stability in normal conditions.53 This observation may explain why c-Myc was not always highly expressed in E7 expressing cells.40 These results indicate that GCN5 could acetylate c-Myc, stabilize it, affect its level of binding to the E2F1 promoter, regulate E2F1 expression and modulate cell cycle progression."
30079588
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"Reportedly, c-Myc promoted myoblast proliferation and muscle fiber hypertrophy in chickens by targeting the cell cycle pathway."
34490239
reach
"There are other detected mutations (eg, TP53, PIM1, BAX, and CCND3) that may arise before or after the MYC translocation and further enhance MYC-driven cell cycle progression and cell survival."
35687491
reach
"In human pancreatic endocrine cell lines c-myc downregulation by RNAi induces cells to exit the cell cycle and enter the differentiation pathway, thus c-myc plays a role in the switch mechanism that controls the inverse relationship between proliferation and differentiation XREF_BIBR."
22292012
reach
"Consistent with its role in the regulation of c-Myc expression, Gfi1 promoted Myc driven cell cycle progression and proliferation."
| PMC
reach
"Several parallel mechanisms account for Myc mediated stimulation of the cell cycle."
24704206
reach
"Overexpression of c-myc activates apoptosis and cell cycle arrest at the G1/S phase."
28731177
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"Thus, Rb and p130 have overlapping functional roles in vivo to suppress cell cycle activators, including Myc, and maintain quiescence in postnatal cardiac muscle."
15743840
reach
"Myc also induces cells to undergo apoptosis, and the relationship between Myc induced cell cycle entry and apoptosis is discussed."
9552384
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"In contrast, in quiescent p53-null fibroblasts, activation of c-Myc induced cell cycle reentry but not apoptosis."
8091232
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"Elevated levels of c-Myc are known to cause cell cycle progression and cellular immortalization."
25700366
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"et al. c-myc and Bcl-2 modulate p53 function by altering subcell & rtraf & kingduring the cell cycle."
9502191
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"14 As Myc proteins contribute to cell proliferation by activating cell cycle and inducing DNA replication, 28 our results indicate that downregulation of c-Myc contributes to ICCB280 induced proliferation arrest."
26109609
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"While unrepaired DNA damage normally results in cell-cycle arrest, abnormal Myc expression allows unrepaired cells to escape cell cycle checkpoints and proliferate uncontrollably, resulting in neoplasia in humans, mice and rats."
19603522
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"C-Myc can also modulate the expression of cell division cycle 25A (CDC25) gene which encodes an important cell cycle regulator gene [XREF_BIBR]."
24931005
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"XREF_BIBR In addition, MYC promotes cell cycle progression by activation of cyclin D1, Cdk4, Cdc25A, E2F1, and E2F2."
21779462
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"95 In fact, reinforced Myc expression in quiescent cells is sufficient to promote cell cycle entry."
33692331
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"Consistent with previous data, the overexpression of MYC induced by xCT causes cell cycle arrest in G2 [XREF_BIBR]."
29789716
reach
"Moreover, MYC also stimulates the cell cycle by antagonizing the activity of cell cycle inhibitors, such as p15, ARF, p21, and p27 through distinct mechanisms [74]."
32971884
reach
"C-MYC and N-MYC are the two predominant pro tumorigenic members of the MYC family driving cell cycle progression, angiogenesis, genomic instability, and metastasis [XREF_BIBR, XREF_BIBR]."
29207623
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"95 Three leading mechanisms are required for cell cycle stimulation by Myc : upregulation of CDKs and cyclins, downregulation of CDK inhibitors p15 and p21, and degradation of p27."
33692331
sparser
"Altogether, the results strongly indicate that FOXM1 switches the activation of the cell cycle by MYC from differentiation to proliferation in spite of increased replication stress and DNA damage."
27452522
reach
"In D283 Med cells, we found mildly decreased cellular proliferation in response to hypoxia that may be due to hypoxia response elements " functionally counteracting " c-Myc thereby inducing cell cycle arrest."
23082872
reach
"C-Myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways."
8760287
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"FL erythroid precursors showed downregulation of Stat5a, known to promote erythroid cell proliferation and differentiation downstream of Kit 54, and Myc, which was described to mediate cell cycle progression in erythroblasts 55 and was recently shown to be downregulated in Kit W 41 mutants underlying their proliferative defects 56 (Fig XREF_FIG E)."
30166337
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"C-Myc also represses the expression of several negative cell cycle regulators including p15, p21, and p27."
14680481
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"Analysis revealed that WT- and K326R-MYC induced an average of 57 +/-4% and 58 +/-6% of cells to synthesize DNA, respectively, while vehicle treatment alone resulted in 8 +/-6% positive cells, suggesting that SUMOylation of K326 does not play a role in MYC induced cell cycle entry."
25522242
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"Studies say that estrogen, specifically 17 β-estradiol has been reported to upregulate the expression and function of c-Myc and cyclinD1 which leads to the promotion of cell cycle from G1 phase to S phase in the epithelial cells of mammary glands."
31673107
reach
"In normal mammary epithelial cells TGFbeta inhibits cell growth by inducing the expression of cell cycle inhibitors such as CDKN2B (p15) and CDKN1A (p21) and repressing the expression of cell cycle activators such as MYC [XREF_BIBR - XREF_BIBR]."
24330518
reach
"Induction of conditional alleles of Myc is sufficient to stimulate cell cycle re-entry and proliferation in resting cells (Eilers etal., 1991)."
25435281
reach
"By supporting MYC levels, AURKA promotes MYC-dependent transcription that enhances cell cycle progression and cell survival in tumors."
36165728
eidos
"In addition , the four compounds blocked Myc-mediated transcriptional activity in HL-60 cells , as demonstrated in qRT-PCR showing a reduction in cyclin D2 and CDK4 downstream Myc regulated genes , confirming that the cell cycle progression arrest was caused by Myc inhibition ."
30597997
reach
"MYC activation results in upregulation of G 1 -specific cyclins and cyclin dependent kinases, and inhibits negative regulatory factors of cell cycle progression."
28627654
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"In this study, we found that VP treatment remarkably decreased the protein expression of c-Myc and cyclinD1, which may subsequently arrest the cell cycle at the G0/G1 phase."
28924376
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"It arises from B cells, where a chromosomal translocation, more frequently t(8;14)(q24;q32) and less frequently either t(2;8)(p12;q24) or t(8;22)(q24;q11), leads to the deregulated expression of the oncogene C-Myc, which promotes cell cycle progression [35]."
30453922
reach
"In addition to MYC primed apoptosis and metabolism, MYC induced cell cycle progression can be a third option to consider for combined therapeutic targeting."
23897900
reach
"Additionally, it has been shown that MYC and RAS cooperate to induce cell cycle progression into S phase in an Rb independent manner (16)."
15950068
reach
"These results strongly support the notion that increased Myc in adult cardiomyocytes induces cell cycle re-entry that leads to cardiomyopathy and is consistent with a previous report showing that the conditional inactivation of Myc attenuates cardiac hypertrophy induced by pressure overload and other hypertrophic stimuli XREF_BIBR."
19779629
reach
"MYC has been reported to cause G2 cell cycle arrest in cells with wild type TP53 [XREF_BIBR], which is in accordance with the significant suppression mediated by MYC in the discovery screen."
28423600
reach
"When introduced into non permissive cells, c-Myc induces cell cycle arrest, senescence, or apoptosis [XREF_BIBR - XREF_BIBR]."
24418753
reach
"Because c-Myc, b-Myb and cyclin E accelerate the cell cycle and stimulate cell proliferation, it is unlikely that their increases are involved in the suppression of tubular and interstitial cell proliferation in UUO renal injury in Skp2 -/- mice."
22558406
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"Nevertheless, TNKSi predominantly leads to cell type dependent and primary inhibition of the WNT and beta-catenin, YAP, and PI3K and AKT signaling pathways and, subsequently, counteraction of MYC driven cell cycle progression and tumor cell growth (XREF_FIG E)."
34337362
reach
"C-MYC induces cyclin E-CDK2 activity early in the G1 phase of the cell cycle, which is regarded as an essential event in MYC induced G1-S progression [23,24]."
12893289
reach
"To summarize, Naa10 seems to activate and/or amplify the transcriptional activity of beta-catenin and TCF transcriptional activity thereby stimulating cyclin D1 and c-Myc expression leading to inhibition of p21 WAF1 and CIP1 and promoting the G1/S cell cycle transition."
25987439
reach
"C-Myc overexpression and p27 loss cause uncontrolled activation of the cell cycle through several mechanisms."
29715580
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"Having demonstrated that repression of c-myc and ccnd1 are among the downstream effects of CoAA, we next asked whether overexpression of c-myc and ccnd1 can rescue cell cycle progression from inhibition by CoAA."
18829545
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"While the loss of myc strongly impairs cell cycle progression and self-renewal of somatic stem cells, roles for endogenous myc genes in mESC cell cycle have not previously been directly addressed."
20537458
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"44 In studies of lung adenocarcinoma, LPCAT1 has been shown to upregulate MYC and activate the PI3K/AKT pathway.40 Based on the above results, combined with bioinformatics analysis, it was considered that LPCAT1 may stimulate cell cycle procession by upregulating MYC and its downstream molecule CDK1."
35005115
reach
"Consistent with its role in the regulation of c-Myc expression, Gfi1 promoted Myc driven cell cycle progression and proliferation."
33051558
reach
"In mammals, Mad TFs act antagonistically to Myc TFs, which promote the cell cycle, growth and apoptosis, and reduce H ferritin expression [XREF_BIBR, XREF_BIBR]."
24531613
reach
"Myc proteins contribute to the control of cell proliferation by regulating cell cycle progression and apoptosis, and play important roles in cancer XREF_BIBR as well in establishment of pluripotency XREF_BIBR."
24643012
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"HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes."
36337898
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"In several cell culture models activated Ras and Raf signalling leads to a G1 cell cycle arrest which can, however, be rescued by expression of dominant negative p53 or Myc."
10382541
reach
"Additionally, hypophosphorylated β-catenin transfers into the nucleus and binds to transcription factors, leading to transcriptional activation of specific target genes, including Cyclin D1, C-MYC, and MMP-7, all of which contribute to cell survival, cell cycle, uncontrolled proliferation, and distant metastasis (20)."
32596150
reach
"We tested if cell cycle arrest induced by MYC inactivation is reversible (XREF_FIG, ON-OFF-BackON)."
25117713
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"In fact, MYC induction in CaMKII-MYC mice induced neuronal specific cell cycle re-entry, neurodegeneration and cognitive decline."
20584423
reach
"To circumvent both of these problems and to study the importance of Myc driven cell cycle re-entry in the pathogenesis of cardiomyopathy, we used a tetracycline controlled system to generate bitransgenic mice (MHC-Myc) that inducibly overexpress Myc under the control of the alphaMHC gene promoter that drives high transgene expression specifically in cardiomyocytes XREF_BIBR."
19779629
reach
"MYC is essential for proliferation of cap mesenchyme in vivo and, together with JUN, activates G1-phase cell cycle regulators, explaining the proliferative effect of BMP7 stimulation XREF_BIBR."
26634297
reach
"We show that onset of endothelial cell proliferation is induced shortly after Myc induced cell cycle entry of beta cells."
16980582
reach
"These genes are normally repressed by c-myc, as c-myc is promoting the cell cycle and driving proliferation."
20383333
reach
"They still are too closely wedded to moving forward with cocktails of drugs targeted against the growth promoting molecules (such as HER2, RAS, RAF, MEK, ERK, PI3K, AKT and mTOR) of signal transduction pathways instead of against Myc molecules that specifically promote the cell cycle."
23303309
eidos
"Downregulation of c-Myc Expression Enhanced the Effect of Bufalin on Cell Cycle Arrest in Pancreatic Cancer Cells In our previous study , we have reported that bufalin inhibits pancreatic cancer cell growth by inducing cell cycle arrest at the S phase ( Liu et al ., 2016 ) ."
32362830
reach
"As seen in XREF_FIG, MYC overexpression rescued cells from CPI203 induced growth inhibition and cell cycle arrest."
25299775
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"These data, taken together, suggest that DLEU1 may function as a tumor suppressor in c-Myc activated BL by repressing cell cycle progression and enhancing programmed cell death via protein protein interaction."
28427156
reach
"While these data provide some evidence that Myc and HRas together drive cardiomyocytes’ entry into the cell cycle with positivity for markers of cytokinesis, productive cell division cannot be formally confirmed without direct cardiomyocyte counting.In healthy adult mammalian heart apoptosis is rare with only 0.01–0.001% TUNEL-positive cardiomyocytes observed."
36337898
reach
"In keeping with these findings, c-Myc overexpression significantly rescued cell cycle arrest in G0/G1 phase induced by USP18 knockdown in PANC-1 cells (XREF_FIG)."
33051403
reach
"Moreover, Myc activation in quiescent cells is sufficient to induce cell cycle entry in the absence of growth factors."
9468463
reach
"30 Treatment of control and EPC1 KD cells with U0126 or PD184352, compounds which are selective inhibitors of MAP2K1/2 (MEK1/2), blocked MAPK1/MAPK3 phosphorylation, reduced baseline levels of MYC, largely abolished the accumulation of MYC seen following EPC1 KD (XREF_FIG) and induced a G 1 cell cycle arrest (XREF_SUPPLEMENTARY)."
24166297
reach
"MYC has been shown to promote cell cycle progression in many cell types, the MAD family known as “MYC antagonist” or “transcriptional repressor” inhibits cell proliferation (11)."
33718080
reach
"MYC promotes the cell cycle and inhibits apoptosis [25, 26]."
29902866
reach
"Combined, this facilitates survival of eBL tumor cells with the c-myc-Igh chromosomal translocation and promotes MYC induced cell cycle progression initiating eBL lymphomagenesis."
29132323
reach
"The apparent paradox that c-Myc can induce both cell cycle progression and apoptosis has obvious conse- quences to our understanding of cancer and normal cell growth."
7626652
reach
"The constitutive overexpression of c‐Myc in these two cell lines significantly increased the cell viability (Figure 2B and Appendix A1 and Figure S4B, Supporting Information), restored the cell cycle progression (Figure 2C and Appendix A1 and Figure S4C, Supporting Information), and protected the cells against apoptotic cell death (Figure 2D and Appendix A1 and Figure S4D, Supporting Information) in the presence of SR140333, confirming that c‐Myc mediates for the response to SR140333 in human CRC cells."
34605226
reach
"In this report, we demonstrated that the glycolytic gene SLC2A1 and cell cycle progression genes CCNA2, CCNE1, and E2F2 were upregulated by MYC through pre-S2 mutant induced MTOR activation, providing a candidate signaling pathway driven by MYC in HBV related HCCs."
25909713
reach
"MYC can stimulate cell cycle progression through several mechanisms."
28333115
reach
"Ubiquitylation of Myc by SCFbeta-TrCP is required for Myc dependent acceleration of cell cycle progression after release from an arrest in S phase."
20852628
reach
"Similarly, the oncogenic transcription factor MYC can trigger either cell cycle progression or cell death, also in a context dependent manner 32."
33473123
reach
"The lacking of senescence induction in these B-ALL cell lines however remains to be elucidated.SMAD2/3 are the principal mediator for TGF-b antiproliferative responses and regulate the transcription o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29408328
reach
"During proliferation, Myc is known to shorten G1 phase and accelerate the cell cycle [XREF_BIBR], and Stat3 could be activated after stimulation of growth factor through Janus Kinase 2 (JAK2)."
27589562
reach
"Overexpression of MYC and cyclin D1 can cause bypass of cell cycle checkpoints and promote tumor cell proliferation [XREF_BIBR, XREF_BIBR]."
29423038
reach
"XREF_BIBR Upon dimerization with Max, another bHLH protein, Myc binds to the E-box sequences of target genes to activate cellular growth and cell cycle progression."
22267917
reach
"Last but not least, MYC further stimulates cell cycle progression by inducing genes directly involved in DNA replication including MCM (minichromosome maintenance), ORC (origin recognition complex), CDC6 (cell division cycle 6), TERT (telomerase reverse transcriptase) and the genes encoding three subunits of the APC/C (ANAPC5, CDC16 and CDC23) [XREF_BIBR]."
28040803
reach
"The abnormal expression of c-Myc in cancers presumably causes a sustained increase in c-Myc protein levels, perhaps throughout the entire cell cycle rather than in a restricted manner, because elevated expression of c-Myc activates expression of many cell cycle regulators such as cyclin D1, D2, CDK4, and CDK6 through binding enhancer box sequences (E-boxes) XREF_BIBR - XREF_BIBR."
28924385
reach
"All three MYC proteins induced cell cycle entry, cell growth and cell proliferation with associated changes in gene expression programs."
| PMC
reach
"Exposure of Myc over-expressing cells to an oligonucleotide encoding the genomic PU27 sequence induced cell cycle arrest and death [XREF_BIBR]."
26683772
reach
"In the context of MYC driven cell cycle progression, this seems to fit with the observations that the expression of MYC in mid-G1 phase is associated with sustained RAS activity [XREF_BIBR]."
28152508
reach
"Our findings regarding MYC 's effect on patient survival and on CDK7 expression were expected, as upregulation of MYC enhances the expression of key elements of the cell cycle such as cyclin D, cyclin E, and the E2F family of transcription factors; MYC also regulates CDK7 phosphorylation [XREF_BIBR, XREF_BIBR]."
32340192
reach
"The transcription factor E2F1 is an additional target of c-Myc promoting cell cycle progression [XREF_BIBR]."
24790987
reach
"The cell cycle arrest and apoptosis induced by activation of p53, NF-kappaB and c-MYC might be critical and serve as a selection force during Ni (II) carcinogenicity, because only the cells have compromised p53, NF-kappaB and c-MYC will be selected for during long term Ni (II) exposure."
25069803
reach
"To evaluate how MYC protein levels affected THZ1-induced apoptotic cell death, we overexpressed MYC in HepG2 and found that exogenously overexpressed MYC promoted cell cycle progression and increased cells in the S phase."
35406486
reach
"Secondly, Myc overexpression causes activation of Cdk2 (in complex with cyclins E or A) and promotes cell cycle progression (Campaner etal., 2010)."
25435281
reach
"Myc and E2f1 promote cell cycle progression, but overexpression of either can trigger p53 dependent apoptosis."
12718877
reach
"Interestingly, down-regulation of c-myc in BC cells induces cell cycle arrest and apoptosis [24,25]."
23266555
reach
"Cell cycle activation by c-myc in a burkitt lymphoma model cell line."
10956386
reach
"CRL4 TRUSS downregulates the c-myc and N-myc transcription factors, which promote cell cycle entry and progression."
26344709
eidos
"In addition , USP12 promotes cell survival , proliferation , tumorigenesis , and cell cycle progression by upregulating BMI-1 , c-Myc , and cyclin D2 [ 24,25,26,27 ] ."
32143396
reach
"Seen from Figure XREF_FIG, after FAMLF-1 gene silencing, phosphorylation state of AKT protein was inhibited, c-Myc and CDK6 proteins were downregulated inducing cell cycle G0/G1 phase arrested, resulting in cell proliferation inhibited in Kasumi-1 cells compared with the CON and NC groups."
29254171
reach
"Remarkably, MYC overexpression in quiescent cells is sufficient to trigger cell cycle entry, reduce the requirement for growth factors, block cell cycle exit, and increase cell size [XREF_BIBR, XREF_BIBR]."
28040803
reach
"Further, Myc upregulates cell cycle genes and represses fibroblast specific gene expression."
22552993
reach
"MYC is a major driver of cancer cell growth and mediates a transcriptional program spanning cell growth, the cell cycle, metabolism, and cell survival."
27081479
reach
"Silencing of E2F1 or c-Myc in OPCs induced decreased expression of cell cycle genes and of transcriptional inhibitors of differentiation while promoting histone reorganization and the initiation of the formation of heterochromatin, characteristic of the differentiated state [48,49]."
33092959
reach
"Since ectopic expression of Myc in neurons causes the cell cycle activation and neurodegeneration in vivo, the current data suggest that induction of Myc by neurotoxic agents or other disease factors might be a key mediator in cell cycle activation and consequent cell death that is a feature of neurodegenerative diseases."
22005580
reach
"At early (low-grade) stages, it suppresses cell growth via induction of CDK inhibitors and downregulation of the cell cycle driver c-Myc."
29044189
reach
"It has been suggested that the proliferation and cell cycle progression caused by Myc is in part due to its activation of mitochondrial biogenesis and oxidative phosphorylation XREF_BIBR, XREF_BIBR, XREF_BIBR, which are critical for cell proliferation."
18335064
eidos
"Increased cMyc expression , which promotes the cell cycle , and decreased expression of cell cycle inhibitors p21 and p57 have also been reported in purified obese HSCs ."
33554957
reach
"The best known of them is Miz-1, a zinc finger protein involved in Myc dependent repression of cell cycle inhibitors - p15-INK4b (Cyclin dependent kinase 4 inhibitor B) and p21 (CDKN1 : cyclin dependent kinase inhibitor 1) - and in Myc dependent apoptosis in response to growth factor withdrawal XREF_BIBR - XREF_BIBR."
21811581
reach
"In order to gain a better understanding of the molecular mechanisms that are likely to underpin the effects of the DeltaN Bcat mutation on intestinal tumor multiplicity, we monitored expression of the Wnt and beta-catenin target genes myc and Ccnd1, which serve as a gatekeeper in Apc dependent tumor formation and promote cell cycle progression, respectively."
26398937
reach
"Overexpression of the Myc proteins induces cell cycle progression and apoptosis [34]."
16716599
reach
"MYC-MAX interaction is essential for MYC induced cell cycle progression, cellular transformation, and transcriptional activation."
12880971
reach
"Activation of c-myc expression in quiescent cells is sufficient to mediate cell cycle entry, whereas inhibition of c-myc expression causes cycling cells to withdraw from the cell cycle."
9315103
reach
"For example, overexpression of MYC or mutant RAS triggers cell cycle checkpoints and leads to senescence or apoptosis in primary cells."
19789351
reach
"CRL4 TRUSS downregulates the c-myc and N-myc transcription factors, which promote cell cycle entry and progression (Choi et al., 2010)."
26344709
reach
"Thus, cell cycle modulators, such as MYC, hypoxia-inducible factor-1 subunit alpha (HIF-1alpha), and checkpoint kinase 1 (CHK1), regulated by CMA activity will be discussed."
32971884
reach
"As expected, an acute activation of Myc alone was not sufficient to induce cell cycle re-entry."
26073086
reach
"MYC stimulated cell cycle progression has also been well studied."
24444383
reach
"Among the most significantly downregulated genes in SmgGDS depleted cells are E2F1, MYBL2 (B-Myb), FoxM1 and MYC, which are transcription factors that promote the cell cycle XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR (XREF_FIG)."
28806394
reach
"These data suggest that one downstream pathway for Myc directed cell cycle control is the induction of ODC expression."
8297793
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"Myc is thought to contribute to tumorigenesis by deregulating gene expression and abrogating cell cycle checkpoints, thereby driving uncontrolled cellular growth and promoting cell proliferation."
22422827
reach
"The inhibition of c-myc expression blocks cell cycle pro- gression and leads to Gl arrest [22]."
9310266
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"Furthermore, as part of the changes in neuroblastomas, AHR is able to downregulate the expression of proto-oncogene c-Myc, induce differentiation in tumor cells, and cause cell cycle arrest and apoptosis."
33907570
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"IL-2 has been shown to contribute to CD4 + -T cell survival by both upregulation of the anti-apoptotic factor bcl2, the cell cycle promoter c-myc XREF_BIBR, and IL-7Ralpha expression XREF_BIBR."
22039531
reach
"Small molecules that inhibit E2F or c-Myc transcriptional activity induce cell cycle arrest at the G0/G1 phase.15, 16, 17, 18, 19, 20 On the other hand, the inhibition of ZNF143 by YPC-21661 induced G2/M arrest in accordance with the findings of a previous knockdown analysis.3 These results indicate that the role of ZNF143 in cancer cell proliferation is distinct from those of E2F and c-Myc."
28192620
reach
"Furthermore, the Trop-2 intra-cytoplasmatic domain undergoes cleavage and translocates in the nucleus, where it colocalizes with β-catenin and up-regulates Cyclin D1 and c-Myc expression, promoting cell cycle progression [3,4] (Figure 1)."
| PMC
reach
"C-Myc promotes cell cycle progression by multiple mechanisms."
27697092
reach
"The E2F1 transcription factor is activated by c-myc, which promotes cell cycle progression."
19721809
reach
"In addition, the modest level of MYC overexpression did not cause major changes in the cell cycle profile or timing of cell division in IMEC-MYC."
29523784
reach
"This regulation was not simply an indirect effect of MYC driven cell cycle progression, because when MYC expression was reestablished in serum deprived conditions, the cells did not proliferate but the expression of D2HGDH and L2HGDH was again readily induced (XREF_SUPPLEMENTARY)."
32101699
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"Myc promotes cell cycle progression by coordinated regulation of expression of a number of genes."
12565816
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"Myc oncoproteins promote continuous cell growth, in part by controlling the transcription of key cell cycle regulators."
20519624
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"In mammalian cells, Myc might also be able to promote cell cycle progression by increasing transcription of the Cdc25A phosphatase [44]."
11698190
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"The MYC oncogene can activate cell growth and cell cycle progression gene transcription [XREF_BIBR, XREF_BIBR]."
29246179
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"Compelling evidence indicates that estrogens, especially 17beta-estradiol (E2beta), up-regulate the expression and function of c-Myc and cyclinD1, activate cyclin E-Cdk2 complexes and promote cell cyc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25917453
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"This MYC stabilization enables the tumor cells to overcome a latent G2/M cell cycle arrest that is mediated by AURKA and the tumor suppressor protein p19 (ARF)."
27213815
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"However, the mRNA levels of some of the genes shown in Table 1 are dramatically increased upon activation of Myc in quiescent cells of different model systems, suggesting that Myc differentially upreg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24704206
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"C-Myc also influences cell cycle regulation, as the overexpression of c-Myc stimulates cell cycle progression, whereas c-Myc downregulation exerts the opposite effect."
26300071
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"It is also suggested that c-Myc promotes cell cycle and simultaneously primes activation of the Bcl-2 family controlled mitochondria apoptosis pathway [XREF_BIBR]."
21554952
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"Deletion of the ubiquitin ligase Fbxw7 leads to increased abundance of its target c-Myc, which drives HSC cell cycle entry, differentiation and exhaustion [36–38]."
32452878
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"Myc also targets numerous lncRNAs for transcriptional regulation, which can in turn regulate cell cycle progression."
27070700
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"Activation of Myc has been shown to cause cell growth, loss of differentiation, and cell cycle entry in suprabasal keratinocytes in vivo [XREF_BIBR]."
24864240
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"Over a four-week time course, continuous FBXW7 down-regulation and MYC activation together cause an accumulation of cells in S-phase and G2/M-phase of the cell cycle."
25669969
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"In the suprabasal epidermis [7], c-MYC activation is sufficient to induce cell cycle entry of post-mitotic keratinocytes concomitant with impaired differentiation, culminating in epidermal hyperplasia[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12893289
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"Indeed, those MYC regulated lncRNAs are involved in MYC mediated cell cycle and tumorigenesis [XREF_BIBR]."
26003165
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"Moreover, both LRRFIP1 and LRRFIP2 act as important activators of the canonical beta-catenin/TCF/LEF signaling pathway, binding to Wnt signal mediator Dishevelled (Dvl) as well as beta-catenin, glucocorticoid receptor interacting protein 1 (GRIP1), and p300, which leads to transcription of c-myc and cyclinD1, which stimulates proliferation and cell cycle progression as well as apoptosis."
33330501
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"For example, cofilin activation has been linked to up-regulation of the early response gene c-Myc, which modulates cell cycle progression via regulation of cyclin E, cdk2, and E2F-1."
19188496
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"Evaluation of a panel of cell cycle markers showed that loss of Myc or E2f1-3 in Rb deficient villi prevented the aberrant accumulation of critical cell cycle regulators (XREF_FIG)."
26192440
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"We speculate that during the early reprogramming stage, Myc may also serve to initiate remodeling of the cell cycle to one more reminiscent of a pluripotent cell."
20804970
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"Although a handful of Myc target genes involved in Myc driven cell cycle progression and apoptosis have been identified, its target genes responsible for Myc mediated cell migration and metastasis still remain elusive."
20383141
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"Indeed, debilitation of c-Myc using siRNA revealed down-regulation of CCND2, and induced the correction of abnormal cell cycle progression, which were consistent with the results of the transfection experiments with let-7a, miR-16 and miR-29b in ES cells."
26393798
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"Although we have focused our work on the analysis of c-Myc and p21 expression, as a central regulator of proliferation, c-Myc is expected to target the cell cycle at many different steps."
28851980
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"EGFR signaling to ERK1/2 can result in nuclear translocation of PKM2, where PKM2 protein kinase activity leads to c-Myc and cyclin D1 expression to drive cell cycle progression beyond the G1/S checkpoint."
26300261
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"In conclusion, we show that KLK6 is a proliferative factor in NSCLC that might act by inducing c-Myc synthesis, which in turn modulates specific components of the cell cycle machinery to promote cell cycle progression."
19426157
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"Myc downregulation, on the other hand, causes cells to exit the cell cycle and undergo differentiation [XREF_BIBR]."
26025619
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"C-Myc is upregulated following T cell activation and has been demonstrated by several groups to induce cell cycle progression and glycolytic metabolism."
29868016
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"Nonetheless, the over-expression of aurora kinase genes, in combination with over expression of cell cycle drivers such as cyclin E and Myc, is a recipe for unequal chromosome allocation to daughter cells, and cytoplasmic fragments."
27900612
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"Similarly, Prdm1 directly represses c-myc expression in macrophages and sebaceous gland progenitors to arrest cell cycle progression, but c-myc is not a target in T cells."
23918801
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"C-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins."
20516082
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"In breast cancer estrogen can independently regulate the expression and function of the proto-oncogene c-Myc followed by a rapid activation of the G1 CDK, CDK2, to induce cell cycle progression [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28423577
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"Myc can transcriptionally downregulate cell cycle inhibitors such as p21, and also increase the expression of positive regulators namely the cyclin D, by mechanisms including transcription and translation [XREF_BIBR, XREF_BIBR]."
24858415
eidos
"AURKA was a serine / threonine kinase driving cell-cycle progression by promoting cyclin B1 , Wnt , myc , and other pro-proliferative pathways ( 40 , 41 ) ."
36341390
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"MYC stimulates cell cycle progression and is constantly expressed upon misregulation in cancer, thus leading to continuous overexpression of downstream MYC dependent genes."
26035625
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"In agreement with the tight correlation between proliferation rates and Myc levels, the enforced Myc expression in quiescent cells is sufficient to mediate cell cycle entry, whereas inhibition of Myc [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24704206
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"A RAC1 inhibitor suppressed accumulation of macropinosomes and overexpression of MYC attenuated oncogenic RAS induced such accumulation, cell cycle arrest and cell death."
29106503
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"Hh signaling promotes cell proliferation through the regulation of its direct target genes, i.e. CyclinD, CyclinE, and Myc, which modulate the G1 to S phase cell cycle transition XREF_BIBR."
26931153
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"This difference of upregulation of metabolic related genes may be partly due to c-Myc over-expression, because a previous study indicated that c-Myc caused upregulation of metabolic- and cell cycle related genes in MEFs XREF_BIBR."
27608931
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"Therefore, Myc promotes G1-phase cell cycle progression in part through the transcriptional up-regulation of the cyclin D2 gene [149]."
24704206
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"Ectopic c-MYC overexpression in normal fibroblasts can accelerate cell cycle entry but also induces apoptosis XREF_BIBR."
23634284
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"C-Myc activates expression of cell cycle promoting genes such as cdc25A, cdk4, and cyclins D2, -E, and -A and suppresses expression of cell cycle and growth arrest genes (gas1, p15, p21, p27, and gadd[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12565816
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"Interestingly, our previous studies have shown that cell cycle activation by c-Myc (Myc) leads to neuronal cell death which suggests Myc might be a key regulator of cell cycle reentry mediated neuronal cell death."
22005580
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"The apoptosis inhibition and enhancing cell cycle progression are mediated by c-Myc overexpression."
35339914
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"Omomyc induces cell cycle arrest and apoptosis in SCLC cells."
27105536
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"C-Myc induces cell cycle associated gene expression by transcriptionally regulating HAT."
29512702
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"One option is therefore that the role of the positive and negative regulators within this network is to maintain MYC driven cell cycle progression under controlled and " safe " conditions."
28665315
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"In quiescent mouse fibroblasts expressing wild-type p53 protein, activation of c-Myc was found to induce apoptosis and cell cycle reentry, preceded by stabilization of p53."
8091232
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"MYC not only directly stimulates the core cell cycle machinery, but also prepares the cells for cell division by globally stimulating cell growth and acquisition of macromolecules so that the cells can successfully progress through different cell cycle checkpoints to complete the mitotic cycle."
28443281
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"Epstein-Barr virus latent membrane protein 2A enhances MYC driven cell cycle progression in a mouse model of B lymphoma."
24174629
reach
"C-Myc stimulates cell cycle progression by increasing transcription of positive cell cycle regulators such as cyclin-dependent kinases (Cdks), cyclins, and E2F TFs [80,81] and inhibiting transcription of the negative regulators such as p21 and p27 [82,83]."
32824207
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"Thus, ablation of MYC would be expected to promote cell cycle arrest in part through the derepression of p21."
22722403
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"Transcription of C/EBPbeta then in cooperation with STAT3 drives MYC expression, which enables accelerated cell cycle progression, leading to increased neutrophil output."
28224211
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"For example, PER1 and CRY2 were reported to regulate p53 controlled checkpoint function by interacting with the tumor suppressor ataxia-telangiectasia mutated (ATM) and Rad3 related (ATR), respectively, whereas CK1epsilon promotes beta-catenin-mediated activation of T-cell-specific transcription factor and lymphoid enhancer factor-1 (TCF/LEF) family that stimulates c-Myc and Cyclin D1 mediated cell cycle progression."
24901356
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"C-Myc mediates PIWIL2-regulatedtumor cell proliferation and cell cycle progress."
25193865
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"The Myc protein was used to quantitatively couple and directly regulate key cell cycle regulating proteins."
29606139
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"Transcription factors, includ- ing the oncogenes JUN, FOS and MYC then direct the mitogenic response by regulating cell cycle progression."
8056144
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"Unlike the setting of sustained proliferation that occurs following T cell activation, in growth-factor-stimulated cell cycle entry of MEFs and potentially other cell types, the reduction in the ratio of MNT-MAX to MYC-MAX may facilitate the induction of MYC target genes that function to promote cell cycle entry while being transient enough to not trigger MYC dependent apoptosis."
28230739
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"Finally, MYC overexpression in hypoxic cells promoted cell cycle progression but also enhanced cell death via increased expression of the proapoptotic genes NOXA and PUMA."
23816886
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"Paradoxically, c-Myc promotes both cell cycle progression and apoptosis under low serum condition [XREF_BIBR, XREF_BIBR]."
15811177
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"Cyclin D3 and c-MYC control glucocorticoid induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells."
14576768
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"Myc function in vitro is reliant upon the E2Fs, a family of transcription factors essential for Myc mediated cell cycle progression and apoptosis."
26474282
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"During early stages, TGFbeta plays an inhibitory role on tumor cell growth and proliferation by inducing CDK inhibitors (p15 and p21) and suppressing cell cycle stimulators such as Myc, CDK4, and CDC25A XREF_BIBR, XREF_BIBR."
32393769
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"Cyclin D1 and c-myc are the significant target genes of the Wnt signaling pathway and cause alterations to cell cycle, cell proliferation and cell survival [XREF_BIBR, XREF_BIBR]."
26296196
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"It has been shown that MYC promotes cell cycle progression of cancer cells to enhance an uncontrolled cellular proliferation in various malignances [XREF_BIBR]."
22545051
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"Alternatively, MP may also suppress the expression of c-myc or cyclins, which can stimulate cell cycle progression [20]."
34820026
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"In the hematopoietic cell line BAF-B03, the expression of any two of lckF505 (an active form of p56lck), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway."
7736574
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"Co-injection of c-myc, but not EJ-ras, c-fos or c-jun, inhibits the ability of Rb to arrest the cell cycle."
1436095
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"Mechanistically, significant enhancement of G1/S cell cycle arrest, mediated by depletion of MYC and MYCN and E2F transcriptional output sensitized RAS driven neuroblastomas to trametinib following YAP1 deletion."
31672841
reach
"Oskarsson et al. demonstrated that c-Myc null epidermis resisted Ras driven tumorigenesis, and during epidermal tumorigenesis, c-Myc inhibited the expression of the cell cycle inhibitor, p21 [43]."
17727842
reach
"However, in the early stage of LADC, telomere maintenance and cell cycle are caused by the mediation of gene TERT and mediation of genes, RB1, E2F1, CDK6, and MYC, respectively."
31217907
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"Our data indicate that this delay is not a consequence of an impaired DDR or p53 dependent apoptotic response but rather of an altered ability of Myc to accelerate cell cycle traverse of the tumour initiating cells."
22081066
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"In contrast, although MYC promotes rapid cell cycle entry of pancreatic beta-cells, these cells quickly proceed to undergo apoptosis leading to severe cell depletion and diabetes [XREF_BIBR]."
21961992
reach
"In primary keratinocytes, the activation of MYC drives the cell cycle in 1-2 days and epidermal differentiation in 5-6 days."
27452522
reach
"The enhanced proliferative ability of trp53 deficient mice correlates with a decreased expression of the mitotic inhibitor Cdkn1a and p21 cip and an increase in c-myc, a transcription factor that promotes cell cycle progression."
22777914
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"In this study, we found that LG268 treatment remarkably reduced the expression of c-Myc and cyclin D1, which may subsequently arrest the cell cycle at the G0/G1 phase."
27429588
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"Transgenic c-Myc overexpression driven by the alpha-myosin heavy chain (MHC) promoter enhances cardiac proliferation, but also accelerates the cell cycle withdrawal of cardiomyocytes during the perinatal period 42."
27301468
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"Loss of c-Myc decreases the expression of cell cycle associated genes and induces G2/M-phase arrest."
29512702
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"We conclude that v-Jun shares the capacity of the Myc, E1A, and E2F oncoproteins to promote both cell cycle progression and apoptosis under conditions of mitogen depletion."
9101083
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"Further, ectopic MYC overexpression in some contexts may also cause cell cycle arrest XREF_BIBR (e.g. human fibroblasts) or even terminal differentiation XREF_BIBR (e.g. human keratinocytes)."
20195545
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"YAP1 binds to promoters pre-bound by both TEAD and MYC and MYC-driven cell cycle entry depends on YAP activity."
33428889
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"Expression of c-Myb and c-Myc in myeloid progenitor cells and forced expression in mature macrophages induce cell cycle entry and proliferation (Graf, 1992; Roussel, 1997)."
24070388
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"Here, we found Myc induction precedes camptothecin mediated neuronal cell death and these data suggest Myc mediated cell cycle activation might be a potential mechanism."
22005580
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"To confirm this proposition, we focused on the cell cycle promoter c-Myc, a known target of the TGF-beta pathway that is transcriptionally repressed through direct binding of Smad to its promoter."
25238097
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"(ii) the level of expression of mel-18 mRNA and that of c-myc mRNA are in inverse correlation in mel-18 transfectants of NIH3T3 cells (Kanno et al., 1995; M.H. and M.K. : manuscript in preparation); ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9809583
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"Up-regulated c-Myc induces cell cycle arrest in the G1 phase and inhibits the repair effects on telomeres, preventing the cells from being immortalized XREF_BIBR, XREF_BIBR."
28790461
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"Furthermore, luciferase reporter screening studies revealed that bufalin inhibited the expression and activity of the transcription factors c-Myc and NF-kappaB, which might cause cell cycle arrest at S phase and the inhibition of cell proliferation."
27686271
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"C-Myc targeted cell cycle regulators in lung cancer."
26427040
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"These results support the proposal that c-Myc enhances the susceptibility to 5-FU of colorectal cancer cells by promoting cell cycle S-phase entry and therefore represents a novel therapeutic target in colorectal cancer treatment."
29137264
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"MYC protein accumulation accelerates the transcription of numerous cell cycle promoting genes."
30018743
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"Interestingly, loss of caspase-3 led to an inhibition of the cell cycle otherwise stimulated by sustained c-myc expression, suggesting a role of Caspase-3 in proliferation [XREF_BIBR]."
24281211
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"We represented it as a continuous signal and now the relationship (continuous dynamic) between Growth factor activated c-Myc and Cyclin D that initiates cell cycle is realistically represented."
28647496
reach
"Besides its direct effect on transcription, MYC also positively regulates the cell cycle by controlling the activities of the cyclin/CDK complex thorough the induction of CDK-activating kinase (CAK) and CDC25 phosphatases."
32971884
reach
"Interestingly, c-myc, a potent oncogene that promotes cell cycle progression, is a beta-catenin and Tcf transcriptional target (He et al. 1998)."
11149923
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"Our analysis indicates that the BMP7-TAK1-JNK-JUN pathway regulates JUN cell cycle targets including Myc throughout nephrogenesis, but that the contribution of MYC itself to control of G1 targets is limited to later stages of nephrogenesis."
26634297
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"Thus, MDA-MB-231 cells may overcome hypoxia induced cell cycle arrest by overexpressing MYC, which in turn deactivates p21 to enable cell cycle progression."
30127847
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"MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also through the downregulation or the impairment of the activity of a set of proteins that act as cell-cycle brakes."
30909496
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"Finally we show that BAMBI promotes the expression of c-myc and cyclin D1 and increases Wnt promoted cell cycle progression."
18838381
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"Persistently up-regulated eIF4F mediated translation in cancers is due to sustained signals emanating from constitutively activated cell cycle promoters such as Myc, Ras and Akt."
25263391
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"Down-regulation of cyclin A, c-Myc, Skp2, phosphorylated Rb, and Cdk2, coupled with increased phospho-cRaf (S259), p21 Cip and p27 Kip1 abundance likely contributed to the sustained induction of G1 cell cycle arrest following 96 h CAPE treatment."
22562408
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"These new models suggest that Myc behaves as an amplifier of existing cellular states, however, Myc activation has been largely linked with cell proliferation and elevated levels of Myc are sufficient to drive cell growth and cell cycle progression [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
24710550
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"Considerable evidence has therefore ac- cumulated demonstrating that c-Myc can act as an onco- protein to promote cell cycle progression and tumorigene- sis."
7626652
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"Like many immediate early growth response genes, c-myc over-expression was sufficient to drive cell proliferation [22] and to promote cell cycle progression from G1 to S phase by regulating expression[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11337017
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"However, a study in MYC inducible cancer cell lines has shown that highly proliferating MYC expressing cells require active OxPhos together with increased glycolysis to drive their fast cell cycle progression."
33585251
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"To determine the kinetics of oncogenic response, we assessed G 1 cell cycle arrest induced by K-ras or Myc activation [XREF_BIBR, XREF_BIBR]."
27507053
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"C-Myc overexpression was used to rescue the cell cycle arrest and tumor growth induced by DOT1L silencing or inhibition in CRC."
31888761
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"To test whether Myc expression induces cell cycle re-entry in adult cardiomyocytes, we measured the expression level of PCNA, Ki67, and cyclin D1, which increase during the cell cycle."
19779629
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"dlst heterozygous loss in Myc overexpressing tumor cells decreases cell mass and slows cell cycle progression."
26876595
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"On one hand, Myc could directly induce genes that are critical to cell cycle; on the other hand, Myc is able to hyperactivate cyclin and Cdk and antagonizes the activity of cell cycle inhibitors as p21 and p27."
29230196
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"Co-activating the cell cycle activator Myc and Notch1 in the inner ear can induce the proliferation of different types of cochlear sensory epithelial cells."
34489646
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"Since G2/M arrest was also induced in H345 omo cells, it is likely that Omomyc effectively induces cell cycle arrest in either G1 or G2/M phase in SCLC cells."
27105536
reach
"In the case of LNCaP cells, upregulated miR-449a directly downregulates c-Myc that is required to induce the cell cycle regulators Cdc25A and Cdc2 and CyclinB whose inactivation blocks G2 to M phase transition."
30024932
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"In fact, ubiquitylation of MYC through the SCF SKP2 complex appeared to have dual outcomes; in addition to proteasome degradation, SKP2 also promoted and was even required for MYC driven transcription of cell cycle associated genes and for MYC induced S-phase entry."
28665315
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"Control of pRB phosphorylation Mittnacht 27 This paper demonstrates that c-Myc and oncogenic Ras co-operate to induce cell cycle progression in REF 52 cells in the absence of Cyclin D activation and p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9529601
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"In summary, FOXM1 drove the cell cycle deregulation caused by MYC or loss of p53 from differentiation into increased proliferation."
27452522
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"Although it is known that c-Myc mediates cell cycle progression forming a powerful transcriptional activator through a hetero-dimerization with Max [21-25] implicated in differentiation, cell growth a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30253944
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"Increased expression of cyclinD2 or Myc can promote neonatal cardiomyocyte cell cycle activity, but also leads to multinucleation of cardiomyocytes later in life."
23152492
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"In these particular cells, miR-210 activates the myc pathway, via downregulation of the c-Myc antagonist MNT, and loss of MYC abolished miR-210-mediated override of hypoxia induced cell cycle arrest."
21360638
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"The latter modulates MYC protein stability, also acting as a transcriptional co-factor and enhancer of MYC-dependent activation of cell cycle-related genes ."
31900399
reach
"In the hema- topoietic cell line BAF-B03, the expression of any two of IckF505 (an active form of p56 ~ *), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regard- less of the acti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
7736574
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"This review is focused on the role of MYC as a cell-cycle brake releaser i.e., how MYC stimulates the cell cycle mainly through the functional inactivation of cell cycle inhibitors."
30909496
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"Indeed, one can now propose a model whereby Myc regulation of DLEU2 affects the levels of both Cyclins D1 and E1 to promote cell cycle progression."
19591824
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"These results indicated that RNAi mediated knockdown of MYC strongly suppresses the proliferation and anchorage independent growth of ccRCC cells.To further investigate the role of MYC on the malignan[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18809243
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"Transfection of c-Myc directed antisense oligonucleotides to the cultured medulloblastoma cells could reduce c-Myc expression, inhibit cell growth and arrest the cell cycle at S phase."
16724266